FLCN [The Human Chemical-Genetic Interaction Map Project]

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======= FLCN =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FLCN
  * **<color #00a2e8>Official Name</color>**: folliculin
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=201163|201163]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8NFG4|Q8NFG4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FLCN&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FLCN|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607273|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene is located within the Smith-Magenis syndrome region on chromosome 17. Mutations in this gene are associated with Birt-Hogg-Dube syndrome, which is characterized by fibrofolliculomas, renal tumors, lung cysts, and pneumothorax. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  May be a tumor suppressor. May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1. {ECO:0000269|PubMed:12204536, ECO:0000269|PubMed:17028174, ECO:0000269|PubMed:18663353}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Folliculin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of mitochondrial DNA metabolic process|
|regulation of mitochondrial DNA metabolic process|
|negative regulation of ATP biosynthetic process|
|negative regulation of post-translational protein modification|
|regulation of post-translational protein modification|
|negative regulation of cellular respiration|
|negative regulation of cell proliferation involved in kidney development|
|negative regulation of nucleotide biosynthetic process|
|negative regulation of purine nucleotide biosynthetic process|
|regulation of pro-B cell differentiation|
|regulation of lymphoid progenitor cell differentiation|
|regulation of cell proliferation involved in kidney development|
|positive regulation of TORC1 signaling|
|negative regulation of kidney development|
|regulation of ATP biosynthetic process|
|negative regulation of purine nucleotide metabolic process|
|negative regulation of nucleotide metabolic process|
|cell-cell contact zone|
|negative regulation of Rho protein signal transduction|
|negative regulation of ATP metabolic process|
|TOR signaling|
|positive regulation of cellular response to transforming growth factor beta stimulus|
|positive regulation of transforming growth factor beta receptor signaling pathway|
|negative regulation of protein localization to nucleus|
|regulation of cellular respiration|
|energy homeostasis|
|regulation of TORC1 signaling|
|regulation of purine nucleotide biosynthetic process|
|positive regulation of TOR signaling|
|regulation of nucleotide biosynthetic process|
|negative regulation of protein kinase B signaling|
|negative regulation of cold-induced thermogenesis|
|negative regulation of TOR signaling|
|negative regulation of muscle tissue development|
|negative regulation of Ras protein signal transduction|
|negative regulation of mitochondrion organization|
|regulation of kidney development|
|regulation of histone acetylation|
|positive regulation of intrinsic apoptotic signaling pathway|
|negative regulation of small GTPase mediated signal transduction|
|regulation of peptidyl-lysine acetylation|
|negative regulation of ERK1 and ERK2 cascade|
|regulation of protein acetylation|
|regulation of hematopoietic progenitor cell differentiation|
|regulation of cytokinesis|
|negative regulation of small molecule metabolic process|
|regulation of TOR signaling|
|guanyl-nucleotide exchange factor activity|
|positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|cell-cell junction assembly|
|negative regulation of cellular protein localization|
|regulation of transforming growth factor beta receptor signaling pathway|
|regulation of cellular response to transforming growth factor beta stimulus|
|regulation of protein localization to nucleus|
|regulation of purine nucleotide metabolic process|
|regulation of nucleotide metabolic process|
|regulation of ATP metabolic process|
|positive regulation of autophagy|
|negative regulation of DNA metabolic process|
|regulation of muscle tissue development|
|cell-cell junction organization|
|regulation of Rho protein signal transduction|
|regulation of cold-induced thermogenesis|
|regulation of histone modification|
|midbody|
|regulation of generation of precursor metabolites and energy|
|regulation of intrinsic apoptotic signaling pathway|
|negative regulation of MAPK cascade|
|regulation of cell division|
|cell junction assembly|
|positive regulation of apoptotic signaling pathway|
|regulation of mitochondrion organization|
|negative regulation of cell growth|
|regulation of chromatin organization|
|cilium|
|cell junction organization|
|regulation of protein kinase B signaling|
|regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|regulation of Ras protein signal transduction|
|negative regulation of growth|
|lysosome|
|negative regulation of cell migration|
|protein-containing complex binding|
|regulation of cellular response to growth factor stimulus|
|negative regulation of cell motility|
|GTPase activator activity|
|regulation of ERK1 and ERK2 cascade|
|negative regulation of cellular component movement|
|negative regulation of locomotion|
|multicellular organismal homeostasis|
|regulation of autophagy|
|regulation of small GTPase mediated signal transduction|
|regulation of chromosome organization|
|regulation of DNA metabolic process|
|positive regulation of cellular catabolic process|
|negative regulation of organelle organization|
|in utero embryonic development|
|regulation of apoptotic signaling pathway|
|positive regulation of cell adhesion|
|negative regulation of protein phosphorylation|
|positive regulation of GTPase activity|
|regulation of cell growth|
|regulation of small molecule metabolic process|
|positive regulation of catabolic process|
|negative regulation of phosphorylation|
|regulation of hemopoiesis|
|regulation of GTPase activity|
|negative regulation of intracellular signal transduction|
|regulation of cellular protein localization|
|hemopoiesis|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|negative regulation of protein modification process|
|hematopoietic or lymphoid organ development|
|chordate embryonic development|
|positive regulation of apoptotic process|
|immune system development|
|positive regulation of programmed cell death|
|embryo development ending in birth or egg hatching|
|regulation of growth|
|negative regulation of cell population proliferation|
|regulation of cell adhesion|
|positive regulation of cell death|
|negative regulation of cellular component organization|
|regulation of MAPK cascade|
|regulation of cell cycle process|
|positive regulation of hydrolase activity|
|regulation of cellular catabolic process|
|regulation of cell migration|
|negative regulation of transcription by RNA polymerase II|
|regulation of cell motility|
|regulation of cellular localization|
|negative regulation of developmental process|
|embryo development|
|regulation of locomotion|
|regulation of cellular component movement|
|regulation of catabolic process|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|regulation of protein localization|
|negative regulation of cellular protein metabolic process|
|positive regulation of phosphorylation|
|negative regulation of protein metabolic process|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|regulation of cell cycle|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|positive regulation of transcription by RNA polymerase II|
|positive regulation of protein modification process|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of signal transduction|
|regulation of hydrolase activity|
|regulation of organelle organization|
|negative regulation of RNA metabolic process|
|negative regulation of cell communication|
|negative regulation of signaling|
|negative regulation of cellular macromolecule biosynthetic process|
|positive regulation of catalytic activity|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of protein phosphorylation|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|regulation of apoptotic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|regulation of programmed cell death|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|positive regulation of signal transduction|
|regulation of immune system process|
|regulation of cell death|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp100|NFN1 1μM R03 exp100]]|-2.25|
|[[:results:exp281|Disulfiram 4.3μM R06 exp281]]|-2.12|
|[[:results:exp160|Ribavirin 10 to 15μM on day4 R04 exp160]]|-1.98|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|-1.96|
|[[:results:exp462|Cadmium 60μM R08 exp462]]|-1.93|
|[[:results:exp99|NFN1 0.4μM R03 exp99]]|-1.82|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|-1.79|
|[[:results:exp476|Dihydrosphingosine 8μM R08 exp476]]|-1.78|
|[[:results:exp406|Thalidomide 20μM R07 exp406]]|-1.74|
|[[:results:exp423|Zebularine 20μM R07 exp423]]|-1.72|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|1.71|
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|1.73|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|1.74|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|1.76|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|1.82|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|1.87|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|1.92|
|[[:results:exp211|AICAR 240μM R05 exp211]]|1.98|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|2.06|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|2.1|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|2.13|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|2.2|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|2.43|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|2.53|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|2.54|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|3.14|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|4.83|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|4.87|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:f:fnip1|FNIP1]]|0.693|
|[[:human genes:l:lamtor4|LAMTOR4]]|0.682|
|[[:human genes:l:lamtor2|LAMTOR2]]|0.68|
|[[:human genes:w:wdr24|WDR24]]|0.605|
|[[:human genes:l:lamtor1|LAMTOR1]]|0.558|
|[[:human genes:l:lamtor5|LAMTOR5]]|0.558|
|[[:human genes:r:rraga|RRAGA]]|0.555|
|[[:human genes:l:lamtor3|LAMTOR3]]|0.516|
|[[:human genes:c:casp3|CASP3]]|0.497|
|[[:human genes:v:vps41|VPS41]]|0.494|
|[[:human genes:m:mios|MIOS]]|0.483|
|[[:human genes:c:ccnc|CCNC]]|0.47|
|[[:human genes:l:lsm12|LSM12]]|0.463|
|[[:human genes:t:tbc1d5|TBC1D5]]|0.439|
|[[:human genes:p:pax5|PAX5]]|0.432|
|[[:human genes:i:ikzf1|IKZF1]]|0.425|
|[[:human genes:i:irf2|IRF2]]|0.416|
|[[:human genes:w:wdr59|WDR59]]|0.415|
|[[:human genes:t:tnfrsf10b|TNFRSF10B]]|0.415|
|[[:human genes:r:rptor|RPTOR]]|0.408|
|[[:human genes:c:cdk6|CDK6]]|0.405|
|[[:human genes:f:fbxo11|FBXO11]]|0.404|
|[[:human genes:d:dohh|DOHH]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2450
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.73 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FLCN Expression in NALM6 Cells: 5.73'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>