FLII [The Human Chemical-Genetic Interaction Map Project]

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======= FLII =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FLII
  * **<color #00a2e8>Official Name</color>**: FLII actin remodeling protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2314|2314]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q13045|Q13045]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FLII&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FLII|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600362|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein with a gelsolin-like actin binding domain and an N-terminal leucine-rich repeat-protein protein interaction domain. The protein is similar to a Drosophila protein involved in early embryogenesis and the structural organization of indirect flight muscle. The gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  May play a role as coactivator in transcriptional activation by hormone-activated nuclear receptors (NR) and acts in cooperation with NCOA2 and CARM1. Involved in estrogen hormone signaling. Involved in early embryonic development (By similarity). May play a role in regulation of cytoskeletal rearrangements involved in cytokinesis and cell migration, by inhibiting Rac1-dependent paxillin phosphorylation. {ECO:0000250, ECO:0000269|PubMed:14966289}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|LRR 4|
|Gelsolin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|actin filament severing|
|brush border|
|microtubule organizing center|
|actin filament binding|
|actin binding|
|focal adhesion|
|actin cytoskeleton organization|
|actin filament-based process|
|cytoskeleton organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|-2.26|
|[[:results:exp125|GSK461364A 0.005μM R03 exp125]]|-2.02|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|1.85|
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|1.87|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|2|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|3.44|
|[[:results:exp72|LB-100 4.1μM R02 exp72]]|3.95|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:pfn1|PFN1]]|0.469|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 32/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|2/28|
|bone|0/26|
|breast|2/33|
|central nervous system|1/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|0/21|
|liver|0/20|
|lung|2/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|4/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|1/9|
|thyroid|1/2|
|upper aerodigestive|0/22|
|urinary tract|7/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2535
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.11 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FLII Expression in NALM6 Cells: 7.11'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>