FLT3 [The Human Chemical-Genetic Interaction Map Project]

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======= FLT3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FLT3
  * **<color #00a2e8>Official Name</color>**: fms related receptor tyrosine kinase 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2322|2322]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P36888|P36888]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FLT3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FLT3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/136351|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia. [provided by RefSeq, Jan 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation of FES, FER, PTPN6/SHP, PTPN11/SHP-2, PLCG1, and STAT5A and/or STAT5B. Activation of wild-type FLT3 causes only marginal activation of STAT5A or STAT5B. Mutations that cause constitutive kinase activity promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways. {ECO:0000269|PubMed:10080542, ECO:0000269|PubMed:11090077, ECO:0000269|PubMed:14504097, ECO:0000269|PubMed:16266983, ECO:0000269|PubMed:16627759, ECO:0000269|PubMed:18490735, ECO:0000269|PubMed:20111072, ECO:0000269|PubMed:21067588, ECO:0000269|PubMed:21262971, ECO:0000269|PubMed:21516120, ECO:0000269|PubMed:7507245}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pkinase Tyr|
|ig|
|Pkinase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|pro-B cell differentiation|
|myeloid progenitor cell differentiation|
|common myeloid progenitor cell proliferation|
|vascular endothelial growth factor-activated receptor activity|
|lymphoid progenitor cell differentiation|
|glucocorticoid receptor binding|
|vascular endothelial growth factor signaling pathway|
|dendritic cell differentiation|
|positive regulation of phosphatidylinositol 3-kinase activity|
|positive regulation of lipid kinase activity|
|cellular response to vascular endothelial growth factor stimulus|
|cytokine receptor activity|
|positive regulation of phospholipid metabolic process|
|regulation of phosphatidylinositol 3-kinase activity|
|transmembrane receptor protein tyrosine kinase activity|
|cellular response to glucocorticoid stimulus|
|protein self-association|
|cellular response to corticosteroid stimulus|
|regulation of lipid kinase activity|
|positive regulation of tyrosine phosphorylation of STAT protein|
|leukocyte homeostasis|
|animal organ regeneration|
|regulation of tyrosine phosphorylation of STAT protein|
|lymphocyte proliferation|
|regulation of phospholipid metabolic process|
|positive regulation of receptor signaling pathway via JAK-STAT|
|mononuclear cell proliferation|
|positive regulation of phosphatidylinositol 3-kinase signaling|
|hematopoietic progenitor cell differentiation|
|positive regulation of receptor signaling pathway via STAT|
|leukocyte proliferation|
|B cell differentiation|
|regulation of phosphatidylinositol 3-kinase signaling|
|regulation of receptor signaling pathway via JAK-STAT|
|regulation of receptor signaling pathway via STAT|
|positive regulation of lipid metabolic process|
|peptidyl-tyrosine phosphorylation|
|response to glucocorticoid|
|peptidyl-tyrosine modification|
|B cell activation|
|regeneration|
|response to corticosteroid|
|cellular response to steroid hormone stimulus|
|positive regulation of peptidyl-tyrosine phosphorylation|
|protein autophosphorylation|
|homeostasis of number of cells|
|receptor complex|
|positive regulation of ERK1 and ERK2 cascade|
|lymphocyte differentiation|
|regulation of peptidyl-tyrosine phosphorylation|
|positive regulation of MAP kinase activity|
|protein-containing complex binding|
|regulation of ERK1 and ERK2 cascade|
|endoplasmic reticulum lumen|
|response to steroid hormone|
|leukocyte differentiation|
|positive regulation of protein serine/threonine kinase activity|
|regulation of MAP kinase activity|
|MAPK cascade|
|lymphocyte activation|
|signal transduction by protein phosphorylation|
|regulation of lipid metabolic process|
|cellular response to growth factor stimulus|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|regulation of protein serine/threonine kinase activity|
|cellular response to lipid|
|response to growth factor|
|positive regulation of protein kinase activity|
|cellular response to organic cyclic compound|
|positive regulation of MAPK cascade|
|cell population proliferation|
|hemopoiesis|
|positive regulation of kinase activity|
|cellular response to hormone stimulus|
|hematopoietic or lymphoid organ development|
|immune system development|
|positive regulation of transferase activity|
|cytokine-mediated signaling pathway|
|viral process|
|enzyme linked receptor protein signaling pathway|
|regulation of MAPK cascade|
|symbiotic process|
|regulation of protein kinase activity|
|interspecies interaction between organisms|
|response to lipid|
|regulation of kinase activity|
|protein homodimerization activity|
|peptidyl-amino acid modification|
|response to hormone|
|positive regulation of cell population proliferation|
|response to organic cyclic compound|
|leukocyte activation|
|protein phosphorylation|
|regulation of transferase activity|
|response to organonitrogen compound|
|cellular response to cytokine stimulus|
|endoplasmic reticulum|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|positive regulation of phosphorylation|
|cell activation|
|response to nitrogen compound|
|response to cytokine|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|phosphorylation|
|integral component of plasma membrane|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|ATP binding|
|regulation of apoptotic process|
|regulation of programmed cell death|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|homeostatic process|
|positive regulation of signal transduction|
|regulation of cell death|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp436|Dynasore 7μM R08 exp436]]|-1.79|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|1.71|
|[[:results:exp458|Bisphenol S 100μM R08 exp458]]|1.82|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 4/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|2/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6091
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.4 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FLT3 Expression in NALM6 Cells: 0.4'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>