FNTB [The Human Chemical-Genetic Interaction Map Project]

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======= FNTB =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FNTB
  * **<color #00a2e8>Official Name</color>**: farnesyltransferase, CAAX box, beta
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2342|2342]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P49356|P49356]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FNTB&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FNTB|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/134636|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Essential subunit of the farnesyltransferase complex. Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C- terminus of several proteins having the C-terminal sequence Cys- aliphatic-aliphatic-X. {ECO:0000269|PubMed:12036349, ECO:0000269|PubMed:12825937, ECO:0000269|PubMed:16893176, ECO:0000269|PubMed:19246009, ECO:0000269|PubMed:8494894}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Prenyltrans|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein farnesyltransferase complex|
|protein farnesyltransferase activity|
|protein farnesylation|
|prenylation|
|protein prenylation|
|regulation of rhodopsin mediated signaling pathway|
|microtubule associated complex|
|regulation of G protein-coupled receptor signaling pathway|
|zinc ion binding|
|regulation of response to external stimulus|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|-2.17|
|[[:results:exp159|Docetaxel 0.001 to 0.002μM on day4 R04 exp159]]|-2.14|
|[[:results:exp261|ABT-702 5μM R06 exp261]]|-2.04|
|[[:results:exp495|IWR1 50μM R08 exp495]]|-2.04|
|[[:results:exp152|SGC2043 10μM R03 exp152]]|-1.95|
|[[:results:exp176|Apcin 50 to 100μM on day4 R04 exp176]]|-1.87|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|-1.87|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|-1.85|
|[[:results:exp20|Etoposide 10μM R00 exp20]]|-1.8|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|-1.8|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|2.48|
|[[:results:exp111|R-DABN 8μM R03 exp111]]|3.75|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|4.38|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|4.58|
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|4.64|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:f:fnta|FNTA]]|0.579|
|[[:human genes:b:bub3|BUB3]]|0.56|
|[[:human genes:z:zwilch|ZWILCH]]|0.558|
|[[:human genes:m:mad2l1bp|MAD2L1BP]]|0.522|
|[[:human genes:k:kntc1|KNTC1]]|0.512|
|[[:human genes:m:mad1l1|MAD1L1]]|0.506|
|[[:human genes:t:trip13|TRIP13]]|0.496|
|[[:human genes:m:mad2l1|MAD2L1]]|0.489|
|[[:human genes:c:ccnb1|CCNB1]]|0.487|
|[[:human genes:z:zw10|ZW10]]|0.476|
|[[:human genes:r:rbm14|RBM14]]|0.471|
|[[:human genes:m:med16|MED16]]|0.458|
|[[:human genes:d:dpagt1|DPAGT1]]|0.451|
|[[:human genes:t:tsen54|TSEN54]]|0.45|
|[[:human genes:b:bub1b|BUB1B]]|0.442|
|[[:human genes:g:gemin8|GEMIN8]]|0.44|
|[[:human genes:c:c14orf80|C14orf80]]|0.44|
|[[:human genes:r:rpp21|RPP21]]|0.433|
|[[:human genes:c:cdc37|CDC37]]|0.427|
|[[:human genes:t:thg1l|THG1L]]|0.418|
|[[:human genes:a:alg1|ALG1]]|0.413|
|[[:human genes:u:uap1|UAP1]]|0.411|
|[[:human genes:p:ppp4c|PPP4C]]|0.409|
|[[:human genes:c:cdca2|CDCA2]]|0.403|
|[[:human genes:t:tbcb|TBCB]]|0.403|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 577/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|21/28|
|blood|17/28|
|bone|20/26|
|breast|27/33|
|central nervous system|49/56|
|cervix|2/4|
|colorectal|12/17|
|esophagus|8/13|
|fibroblast|1/1|
|gastric|11/16|
|kidney|19/21|
|liver|17/20|
|lung|58/75|
|lymphocyte|13/16|
|ovary|18/26|
|pancreas|21/24|
|peripheral nervous system|12/16|
|plasma cell|13/15|
|prostate|0/1|
|skin|20/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|18/22|
|urinary tract|23/29|
|uterus|3/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 621
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.84 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FNTB Expression in NALM6 Cells: 3.84'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>