FOXA2 [The Human Chemical-Genetic Interaction Map Project]

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======= FOXA2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FOXA2
  * **<color #00a2e8>Official Name</color>**: forkhead box A2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3170|3170]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y261|Q9Y261]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FOXA2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FOXA2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600288|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). In embryonic development is required for notochord formation. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs; FOXA1 and FOXA2 seem to have at least in part redundant roles. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; regulates the expression of genes important for glucose sensing in pancreatic beta-cells and glucose homeostasis. Involved in regulation of fat metabolism. Binds to fibrinogen beta promoter and is involved in IL6-induced fibrinogen beta transcriptional activation. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Fork head|
|Fork head N|
|HNF C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of transcription by glucose|
|negative regulation of detection of glucose|
|regulation of detection of glucose|
|negative regulation of transcription from RNA polymerase II promoter by glucose|
|regulation of transcription from RNA polymerase II promoter by glucose|
|positive regulation of transcription from RNA polymerase II promoter by glucose|
|carbon catabolite activation of transcription from RNA polymerase II promoter|
|carbon catabolite regulation of transcription from RNA polymerase II promoter|
|positive regulation of transcription by glucose|
|negative regulation of hexokinase activity|
|regulation of transcription by glucose|
|negative regulation of glucokinase activity|
|carbon catabolite regulation of transcription|
|carbon catabolite activation of transcription|
|positive regulation of gastrulation|
|regulation of glucokinase activity|
|primitive streak formation|
|positive regulation of cell-cell adhesion mediated by cadherin|
|regulation of hexokinase activity|
|regulation of cell-cell adhesion mediated by cadherin|
|negative regulation of epithelial to mesenchymal transition|
|gastrulation with mouth forming second|
|dopaminergic neuron differentiation|
|response to interleukin-6|
|positive regulation of embryonic development|
|regulation of gastrulation|
|endocrine pancreas development|
|negative regulation of cellular carbohydrate metabolic process|
|negative regulation of carbohydrate metabolic process|
|anterior/posterior axis specification|
|regulation of insulin secretion involved in cellular response to glucose stimulus|
|cellular response to nutrient|
|pancreas development|
|adult locomotory behavior|
|regulation of blood coagulation|
|regulation of hemostasis|
|regulation of coagulation|
|regulation of epithelial to mesenchymal transition|
|axis specification|
|cell fate specification|
|regulation of glucose metabolic process|
|endocrine system development|
|regulation of embryonic development|
|regulation of wound healing|
|regulation of cellular carbohydrate metabolic process|
|adult behavior|
|gastrulation|
|negative regulation of DNA-binding transcription factor activity|
|regulation of response to wounding|
|regulation of insulin secretion|
|locomotory behavior|
|regulation of carbohydrate metabolic process|
|regulation of peptide hormone secretion|
|response to nutrient|
|anterior/posterior pattern specification|
|transcription regulatory region DNA binding|
|cellular response to nutrient levels|
|protein domain specific binding|
|cell fate commitment|
|negative regulation of kinase activity|
|positive regulation of cell-cell adhesion|
|cellular response to extracellular stimulus|
|regulation of hormone secretion|
|negative regulation of transferase activity|
|regionalization|
|transcription factor binding|
|cellular response to external stimulus|
|regulation of cell-cell adhesion|
|positive regulation of cell adhesion|
|regulation of small molecule metabolic process|
|regulation of DNA-binding transcription factor activity|
|pattern specification process|
|negative regulation of phosphorylation|
|regulation of protein secretion|
|regulation of peptide secretion|
|regulation of body fluid levels|
|response to nutrient levels|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|response to extracellular stimulus|
|regulation of hormone levels|
|cell junction|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|embryonic morphogenesis|
|behavior|
|DNA-binding transcription factor activity|
|regulation of cell adhesion|
|chromatin organization|
|regulation of protein transport|
|negative regulation of cell differentiation|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|negative regulation of catalytic activity|
|regulation of secretion|
|regulation of kinase activity|
|anatomical structure formation involved in morphogenesis|
|regulation of cellular localization|
|negative regulation of developmental process|
|embryo development|
|regulation of transferase activity|
|neuron differentiation|
|regulation of protein localization|
|regulation of anatomical structure morphogenesis|
|chromosome organization|
|regulation of response to external stimulus|
|response to cytokine|
|negative regulation of molecular function|
|negative regulation of multicellular organismal process|
|positive regulation of transcription by RNA polymerase II|
|positive regulation of developmental process|
|DNA binding|
|regulation of response to stress|
|generation of neurons|
|positive regulation of transcription, DNA-templated|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of phosphorylation|
|negative regulation of response to stimulus|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|regulation of transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp156|UNC2400 2μM R03 exp156]]|-1.81|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 5/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|3/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7701
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -5.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FOXA2 Expression in NALM6 Cells: -5.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>