FRS2 [The Human Chemical-Genetic Interaction Map Project]

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======= FRS2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FRS2
  * **<color #00a2e8>Official Name</color>**: fibroblast growth factor receptor substrate 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10818|10818]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8WU20|Q8WU20]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FRS2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FRS2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607743|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3- kinase, in response to ligand-mediated activation of FGFR1. Modulates signaling via SHC1 by competing for a common binding site on NTRK1. {ECO:0000269|PubMed:12974390, ECO:0000269|PubMed:21765395}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|IRS|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|optic placode formation involved in camera-type eye formation|
|optic placode formation|
|phosphatase activator activity|
|prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis|
|transmembrane receptor protein tyrosine phosphatase signaling pathway|
|prostate glandular acinus morphogenesis|
|neurotrophin TRKA receptor binding|
|branching involved in prostate gland morphogenesis|
|ectodermal placode formation|
|prostate glandular acinus development|
|ectodermal placode morphogenesis|
|embryonic camera-type eye formation|
|ectodermal placode development|
|transmembrane receptor protein tyrosine kinase adaptor activity|
|lens fiber cell development|
|anterior/posterior axis specification, embryo|
|organ induction|
|tripartite regional subdivision|
|negative regulation of cardiac muscle cell differentiation|
|blastoderm segmentation|
|neurotrophin TRK receptor signaling pathway|
|negative regulation of cardiocyte differentiation|
|fibroblast growth factor receptor binding|
|prostate gland epithelium morphogenesis|
|prostate gland morphogenesis|
|embryonic camera-type eye morphogenesis|
|lens fiber cell differentiation|
|developmental induction|
|neurotrophin signaling pathway|
|gastrulation with mouth forming second|
|neuroblast proliferation|
|negative regulation of cardiac muscle tissue development|
|embryonic eye morphogenesis|
|regulation of cardiac muscle cell differentiation|
|regulation of animal organ formation|
|embryonic axis specification|
|embryonic camera-type eye development|
|negative regulation of striated muscle cell differentiation|
|prostate gland development|
|negative regulation of striated muscle tissue development|
|negative regulation of muscle organ development|
|anterior/posterior axis specification|
|regulation of cardiocyte differentiation|
|negative regulation of muscle tissue development|
|stem cell proliferation|
|activation of MAPKK activity|
|negative regulation of muscle cell differentiation|
|embryonic pattern specification|
|ventricular septum development|
|neural precursor cell proliferation|
|endomembrane system|
|lens development in camera-type eye|
|regulation of cardiac muscle tissue development|
|fibroblast growth factor receptor signaling pathway|
|positive regulation of animal organ morphogenesis|
|axis specification|
|segmentation|
|gland morphogenesis|
|regulation of striated muscle cell differentiation|
|cell-cell adherens junction|
|cellular response to fibroblast growth factor stimulus|
|cardiac septum development|
|camera-type eye morphogenesis|
|response to fibroblast growth factor|
|cardiac ventricle development|
|regulation of striated muscle tissue development|
|regulation of muscle tissue development|
|regulation of muscle organ development|
|eye morphogenesis|
|regulation of muscle cell differentiation|
|activation of MAPK activity|
|morphogenesis of a branching epithelium|
|gastrulation|
|positive regulation of protein kinase B signaling|
|morphogenesis of a branching structure|
|cardiac chamber development|
|epithelial cell development|
|anterior/posterior pattern specification|
|regulation of protein kinase B signaling|
|sensory organ morphogenesis|
|regulation of animal organ morphogenesis|
|axon guidance|
|positive regulation of MAP kinase activity|
|neuron projection guidance|
|embryonic organ morphogenesis|
|regulation of ERK1 and ERK2 cascade|
|camera-type eye development|
|urogenital system development|
|activation of protein kinase activity|
|regionalization|
|regulation of epithelial cell proliferation|
|positive regulation of protein serine/threonine kinase activity|
|regulation of MAP kinase activity|
|eye development|
|visual system development|
|sensory system development|
|MAPK cascade|
|axonogenesis|
|forebrain development|
|signal transduction by protein phosphorylation|
|axon development|
|gland development|
|reproductive structure development|
|reproductive system development|
|cell morphogenesis involved in neuron differentiation|
|morphogenesis of an epithelium|
|embryonic organ development|
|pattern specification process|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|cellular response to growth factor stimulus|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|cell part morphogenesis|
|regulation of protein serine/threonine kinase activity|
|heart development|
|response to growth factor|
|positive regulation of protein kinase activity|
|positive regulation of MAPK cascade|
|sensory organ development|
|chemotaxis|
|taxis|
|cell population proliferation|
|cell morphogenesis involved in differentiation|
|tissue morphogenesis|
|embryonic morphogenesis|
|positive regulation of kinase activity|
|positive regulation of transferase activity|
|neuron projection development|
|developmental process involved in reproduction|
|epithelial cell differentiation|
|negative regulation of cell differentiation|
|enzyme linked receptor protein signaling pathway|
|cell morphogenesis|
|brain development|
|regulation of MAPK cascade|
|head development|
|regulation of protein kinase activity|
|neuron development|
|cellular component morphogenesis|
|circulatory system development|
|regulation of kinase activity|
|anatomical structure formation involved in morphogenesis|
|negative regulation of developmental process|
|animal organ morphogenesis|
|protein phosphorylation|
|regulation of transferase activity|
|embryo development|
|central nervous system development|
|neuron differentiation|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|epithelium development|
|plasma membrane bounded cell projection organization|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|cell projection organization|
|negative regulation of multicellular organismal process|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|phosphorylation|
|locomotion|
|G protein-coupled receptor signaling pathway|
|positive regulation of developmental process|
|integral component of plasma membrane|
|reproductive process|
|reproduction|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|generation of neurons|
|regulation of apoptotic process|
|movement of cell or subcellular component|
|regulation of programmed cell death|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|neurogenesis|
|cell development|
|positive regulation of signal transduction|
|regulation of cell death|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp490|Hydroxychloroquine 30μM R08 exp490]]|1.96|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18507
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.8 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FRS2 Expression in NALM6 Cells: 4.8'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>