FTSJ2 [The Human Chemical-Genetic Interaction Map Project]

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======= FTSJ2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MRM2
  * **<color #00a2e8>Official Name</color>**: mitochondrial rRNA methyltransferase 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=29960|29960]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UI43|Q9UI43]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FTSJ2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FTSJ2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606906|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O- methyluridine at position 1369 (Um1369) in the 16S mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a universally conserved modification in the peptidyl transferase domain of the mtLSU rRNA. {ECO:0000269|PubMed:25009282, ECO:0000269|PubMed:25074936}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|FtsJ|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|rRNA (uridine-2-O-)-methyltransferase activity|
|rRNA 2-O-methylation|
|rRNA methylation|
|rRNA modification|
|RNA methylation|
|RNA modification|
|rRNA processing|
|rRNA metabolic process|
|macromolecule methylation|
|ribosome biogenesis|
|methylation|
|mitochondrial matrix|
|ncRNA processing|
|ribonucleoprotein complex biogenesis|
|ncRNA metabolic process|
|nucleolus|
|RNA processing|
|mitochondrion|
|RNA metabolic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp285|GW501516 25μM R06 exp285]]|-1.73|
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|1.71|
|[[:results:exp470|Chloroquine 32μM R08 exp470]]|1.76|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|1.76|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|1.8|
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|1.8|
|[[:results:exp82|Torin1 0.08μM R02 exp82]]|1.82|
|[[:results:exp212|Phenformin 20μM R05 exp212]]|1.9|
|[[:results:exp360|Genistein 15μM R07 exp360]]|1.92|
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|1.93|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|1.97|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|1.99|
|[[:results:exp380|NMS-873 0.07μM R07 exp380]]|2.02|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|2.05|
|[[:results:exp111|R-DABN 8μM R03 exp111]]|2.1|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|2.19|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|2.24|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|2.33|
|[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|2.39|
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|2.53|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|2.56|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|2.59|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|2.83|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:n:nars2|NARS2]]|0.688|
|[[:human genes:q:qrsl1|QRSL1]]|0.682|
|[[:human genes:l:lars2|LARS2]]|0.673|
|[[:human genes:m:mrps21|MRPS21]]|0.663|
|[[:human genes:n:ndufb11|NDUFB11]]|0.65|
|[[:human genes:y:yars2|YARS2]]|0.643|
|[[:human genes:p:pet112|PET112]]|0.641|
|[[:human genes:m:mrpl21|MRPL21]]|0.639|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.622|
|[[:human genes:r:rpusd4|RPUSD4]]|0.621|
|[[:human genes:v:vars2|VARS2]]|0.621|
|[[:human genes:a:aars2|AARS2]]|0.612|
|[[:human genes:m:mrpl45|MRPL45]]|0.609|
|[[:human genes:m:mrpl23|MRPL23]]|0.609|
|[[:human genes:c:coa3|COA3]]|0.605|
|[[:human genes:p:pars2|PARS2]]|0.604|
|[[:human genes:g:gfm1|GFM1]]|0.603|
|[[:human genes:n:ndufs2|NDUFS2]]|0.601|
|[[:human genes:m:mettl17|METTL17]]|0.6|
|[[:human genes:n:ndufa3|NDUFA3]]|0.599|
|[[:human genes:e:ears2|EARS2]]|0.599|
|[[:human genes:s:selrc1|SELRC1]]|0.598|
|[[:human genes:m:mrps16|MRPS16]]|0.597|
|[[:human genes:r:rpusd3|RPUSD3]]|0.593|
|[[:human genes:w:wbscr16|WBSCR16]]|0.593|
|[[:human genes:t:tefm|TEFM]]|0.592|
|[[:human genes:d:dap3|DAP3]]|0.59|
|[[:human genes:t:tars2|TARS2]]|0.59|
|[[:human genes:m:mrps25|MRPS25]]|0.59|
|[[:human genes:m:mrps5|MRPS5]]|0.586|
|[[:human genes:m:mrps6|MRPS6]]|0.585|
|[[:human genes:m:malsu1|MALSU1]]|0.584|
|[[:human genes:d:dars2|DARS2]]|0.582|
|[[:human genes:n:ndufa1|NDUFA1]]|0.58|
|[[:human genes:d:ddx28|DDX28]]|0.579|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.578|
|[[:human genes:m:mrps34|MRPS34]]|0.577|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.577|
|[[:human genes:m:mrps26|MRPS26]]|0.576|
|[[:human genes:m:mrps14|MRPS14]]|0.575|
|[[:human genes:m:mrpl12|MRPL12]]|0.575|
|[[:human genes:m:mars2|MARS2]]|0.571|
|[[:human genes:t:tfb1m|TFB1M]]|0.569|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.566|
|[[:human genes:g:gfm2|GFM2]]|0.565|
|[[:human genes:e:eral1|ERAL1]]|0.563|
|[[:human genes:m:mrp63|MRP63]]|0.562|
|[[:human genes:m:mrpl47|MRPL47]]|0.561|
|[[:human genes:p:pet117|PET117]]|0.558|
|[[:human genes:m:mrpl3|MRPL3]]|0.557|
|[[:human genes:m:mrps12|MRPS12]]|0.557|
|[[:human genes:n:ndufb6|NDUFB6]]|0.556|
|[[:human genes:c:c12orf65|C12orf65]]|0.554|
|[[:human genes:p:polg2|POLG2]]|0.552|
|[[:human genes:c:cars2|CARS2]]|0.552|
|[[:human genes:m:mrpl53|MRPL53]]|0.551|
|[[:human genes:m:mtg1|MTG1]]|0.551|
|[[:human genes:s:ssbp1|SSBP1]]|0.548|
|[[:human genes:m:mterfd2|MTERFD2]]|0.547|
|[[:human genes:m:mrps10|MRPS10]]|0.547|
|[[:human genes:g:gatc|GATC]]|0.547|
|[[:human genes:m:mrpl20|MRPL20]]|0.546|
|[[:human genes:m:mrps35|MRPS35]]|0.544|
|[[:human genes:c:cox11|COX11]]|0.544|
|[[:human genes:f:fastkd5|FASTKD5]]|0.542|
|[[:human genes:m:mrpl4|MRPL4]]|0.541|
|[[:human genes:r:rnmtl1|RNMTL1]]|0.54|
|[[:human genes:p:polg|POLG]]|0.539|
|[[:human genes:m:mterfd1|MTERFD1]]|0.538|
|[[:human genes:n:ndufc2|NDUFC2]]|0.538|
|[[:human genes:h:hmgxb3|HMGXB3]]|0.537|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.537|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.535|
|[[:human genes:r:rars2|RARS2]]|0.534|
|[[:human genes:f:fastkd2|FASTKD2]]|0.533|
|[[:human genes:m:mtif2|MTIF2]]|0.532|
|[[:human genes:a:acad9|ACAD9]]|0.532|
|[[:human genes:s:sco2|SCO2]]|0.532|
|[[:human genes:p:pnpt1|PNPT1]]|0.53|
|[[:human genes:r:rbfa|RBFA]]|0.53|
|[[:human genes:m:mrpl49|MRPL49]]|0.529|
|[[:human genes:c:chchd1|CHCHD1]]|0.529|
|[[:human genes:n:ndufa2|NDUFA2]]|0.528|
|[[:human genes:g:grsf1|GRSF1]]|0.528|
|[[:human genes:m:mrpl22|MRPL22]]|0.527|
|[[:human genes:t:timmdc1|TIMMDC1]]|0.527|
|[[:human genes:m:mrps24|MRPS24]]|0.525|
|[[:human genes:a:aifm1|AIFM1]]|0.523|
|[[:human genes:w:wars2|WARS2]]|0.522|
|[[:human genes:m:mto1|MTO1]]|0.522|
|[[:human genes:m:mrpl44|MRPL44]]|0.521|
|[[:human genes:n:ndufaf5|NDUFAF5]]|0.52|
|[[:human genes:m:mrps27|MRPS27]]|0.52|
|[[:human genes:f:fars2|FARS2]]|0.52|
|[[:human genes:p:polrmt|POLRMT]]|0.517|
|[[:human genes:b:bcs1l|BCS1L]]|0.516|
|[[:human genes:i:ict1|ICT1]]|0.514|
|[[:human genes:g:gtpbp8|GTPBP8]]|0.513|
|[[:human genes:t:trub2|TRUB2]]|0.512|
|[[:human genes:n:ndufv1|NDUFV1]]|0.511|
|[[:human genes:m:mtg2|MTG2]]|0.509|
|[[:human genes:c:coq2|COQ2]]|0.509|
|[[:human genes:n:nubpl|NUBPL]]|0.509|
|[[:human genes:n:ndufs7|NDUFS7]]|0.508|
|[[:human genes:p:ptcd3|PTCD3]]|0.507|
|[[:human genes:m:mrpl17|MRPL17]]|0.507|
|[[:human genes:a:atp5sl|ATP5SL]]|0.506|
|[[:human genes:n:ndufa11|NDUFA11]]|0.504|
|[[:human genes:n:ndufs5|NDUFS5]]|0.5|
|[[:human genes:c:c10orf2|C10orf2]]|0.499|
|[[:human genes:n:ndufaf6|NDUFAF6]]|0.497|
|[[:human genes:m:mrpl39|MRPL39]]|0.496|
|[[:human genes:m:mtpap|MTPAP]]|0.495|
|[[:human genes:e:ecsit|ECSIT]]|0.493|
|[[:human genes:p:prepl|PREPL]]|0.492|
|[[:human genes:t:tomm20|TOMM20]]|0.492|
|[[:human genes:h:hars2|HARS2]]|0.49|
|[[:human genes:m:mrps22|MRPS22]]|0.487|
|[[:human genes:c:cox16|COX16]]|0.487|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.486|
|[[:human genes:c:coa6|COA6]]|0.486|
|[[:human genes:m:mrps18a|MRPS18A]]|0.485|
|[[:human genes:m:mipep|MIPEP]]|0.483|
|[[:human genes:m:mrpl42|MRPL42]]|0.482|
|[[:human genes:n:nsun4|NSUN4]]|0.481|
|[[:human genes:n:ndufb9|NDUFB9]]|0.481|
|[[:human genes:c:clpp|CLPP]]|0.479|
|[[:human genes:l:lrpprc|LRPPRC]]|0.479|
|[[:human genes:m:mrps7|MRPS7]]|0.479|
|[[:human genes:s:sars2|SARS2]]|0.478|
|[[:human genes:m:mrps9|MRPS9]]|0.476|
|[[:human genes:n:ndufa8|NDUFA8]]|0.475|
|[[:human genes:x:xpnpep3|XPNPEP3]]|0.475|
|[[:human genes:m:mrps17|MRPS17]]|0.473|
|[[:human genes:r:rtn4ip1|RTN4IP1]]|0.472|
|[[:human genes:m:mrps33|MRPS33]]|0.472|
|[[:human genes:t:tfam|TFAM]]|0.47|
|[[:human genes:m:mrpl43|MRPL43]]|0.469|
|[[:human genes:m:minos1|MINOS1]]|0.469|
|[[:human genes:m:mrpl55|MRPL55]]|0.468|
|[[:human genes:m:mrpl13|MRPL13]]|0.468|
|[[:human genes:n:ndufb7|NDUFB7]]|0.467|
|[[:human genes:m:mrpl52|MRPL52]]|0.466|
|[[:human genes:m:mcat|MCAT]]|0.465|
|[[:human genes:n:ndufb5|NDUFB5]]|0.462|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.462|
|[[:human genes:n:ndufaf1|NDUFAF1]]|0.46|
|[[:human genes:t:tufm|TUFM]]|0.46|
|[[:human genes:c:cox17|COX17]]|0.459|
|[[:human genes:m:mrpl18|MRPL18]]|0.458|
|[[:human genes:c:cox7b|COX7B]]|0.457|
|[[:human genes:h:higd2a|HIGD2A]]|0.457|
|[[:human genes:m:mrps23|MRPS23]]|0.457|
|[[:human genes:c:c17orf89|C17orf89]]|0.455|
|[[:human genes:t:timm8b|TIMM8B]]|0.454|
|[[:human genes:c:cox15|COX15]]|0.453|
|[[:human genes:a:atp5c1|ATP5C1]]|0.449|
|[[:human genes:p:ptcd1|PTCD1]]|0.447|
|[[:human genes:t:tmem261|TMEM261]]|0.444|
|[[:human genes:t:tomm7|TOMM7]]|0.443|
|[[:human genes:m:mrpl15|MRPL15]]|0.443|
|[[:human genes:n:ndufaf4|NDUFAF4]]|0.442|
|[[:human genes:c:c1qbp|C1QBP]]|0.442|
|[[:human genes:f:foxred1|FOXRED1]]|0.442|
|[[:human genes:c:coq4|COQ4]]|0.439|
|[[:human genes:m:mrpl1|MRPL1]]|0.439|
|[[:human genes:m:mrps2|MRPS2]]|0.438|
|[[:human genes:m:mrpl48|MRPL48]]|0.436|
|[[:human genes:p:pitrm1|PITRM1]]|0.435|
|[[:human genes:a:atp5d|ATP5D]]|0.435|
|[[:human genes:g:gtpbp6|GTPBP6]]|0.434|
|[[:human genes:n:ndufa6|NDUFA6]]|0.434|
|[[:human genes:o:opa1|OPA1]]|0.432|
|[[:human genes:m:mrps18b|MRPS18B]]|0.432|
|[[:human genes:m:mrpl33|MRPL33]]|0.43|
|[[:human genes:m:mrpl38|MRPL38]]|0.429|
|[[:human genes:t:tomm6|TOMM6]]|0.428|
|[[:human genes:m:mrps11|MRPS11]]|0.427|
|[[:human genes:n:ndufa10|NDUFA10]]|0.427|
|[[:human genes:d:dhx30|DHX30]]|0.426|
|[[:human genes:m:mrpl11|MRPL11]]|0.426|
|[[:human genes:c:coq7|COQ7]]|0.425|
|[[:human genes:c:coq6|COQ6]]|0.425|
|[[:human genes:s:slc25a51|SLC25A51]]|0.424|
|[[:human genes:m:mrpl36|MRPL36]]|0.424|
|[[:human genes:p:pdss1|PDSS1]]|0.423|
|[[:human genes:m:mrpl35|MRPL35]]|0.421|
|[[:human genes:s:slc25a3|SLC25A3]]|0.421|
|[[:human genes:n:ndufb3|NDUFB3]]|0.42|
|[[:human genes:n:ndufb4|NDUFB4]]|0.417|
|[[:human genes:m:mrpl28|MRPL28]]|0.417|
|[[:human genes:t:tomm22|TOMM22]]|0.416|
|[[:human genes:n:ndufc1|NDUFC1]]|0.416|
|[[:human genes:t:tmem242|TMEM242]]|0.415|
|[[:human genes:n:ndufb2|NDUFB2]]|0.41|
|[[:human genes:m:mtrf1|MTRF1]]|0.41|
|[[:human genes:a:atp5a1|ATP5A1]]|0.41|
|[[:human genes:n:noa1|NOA1]]|0.409|
|[[:human genes:n:ndufb10|NDUFB10]]|0.406|
|[[:human genes:c:coq3|COQ3]]|0.405|
|[[:human genes:a:aldh18a1|ALDH18A1]]|0.403|
|[[:human genes:i:iba57|IBA57]]|0.403|
|[[:human genes:p:pde12|PDE12]]|0.402|
|[[:human genes:t:timm17a|TIMM17A]]|0.4|
|[[:human genes:n:ndufs1|NDUFS1]]|0.4|
|[[:human genes:c:cox20|COX20]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 18/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|1/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|1/21|
|liver|1/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|1/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 263
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.37 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FTSJ2 Expression in NALM6 Cells: 5.37'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>