FTSJ3 [The Human Chemical-Genetic Interaction Map Project]

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======= FTSJ3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FTSJ3
  * **<color #00a2e8>Official Name</color>**: FtsJ RNA 2'-O-methyltransferase 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=117246|117246]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8IY81|Q8IY81]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FTSJ3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FTSJ3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/618411|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Probable methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation. {ECO:0000255|HAMAP-Rule:MF_03163, ECO:0000269|PubMed:22195017}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Spb1 C|
|DUF3381|
|FtsJ|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|enzyme-directed rRNA 2-O-methylation|
|RNA 2-O-methyltransferase activity|
|rRNA (uridine-2-O-)-methyltransferase activity|
|rRNA (guanine) methyltransferase activity|
|rRNA 2-O-methylation|
|preribosome, small subunit precursor|
|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|
|maturation of LSU-rRNA|
|maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|
|preribosome, large subunit precursor|
|rRNA methylation|
|maturation of 5.8S rRNA|
|rRNA modification|
|ribosomal large subunit biogenesis|
|RNA methylation|
|RNA modification|
|rRNA processing|
|rRNA metabolic process|
|macromolecule methylation|
|ribosome biogenesis|
|methylation|
|ncRNA processing|
|ribonucleoprotein complex biogenesis|
|ncRNA metabolic process|
|nucleolus|
|RNA processing|
|RNA binding|
|RNA metabolic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|-1.98|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|-1.83|
|[[:results:exp536|Vitamin-D3 40μM R08 exp536]]|-1.76|
|[[:results:exp289|Hydroxyurea 15μM R06 exp289]]|1.82|
|[[:results:exp274|Citral 50μM R06 exp274]]|1.92|
|[[:results:exp528|TGF-beta1 44ng/ml R08 exp528]]|2.18|
|[[:results:exp303|39°C R06 exp303]]|2.31|
|[[:results:exp336|Asunaprenir 3μM R07 exp336]]|2.32|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:psmb2|PSMB2]]|0.432|
|[[:human genes:p:pwp2|PWP2]]|0.43|
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.423|
|[[:human genes:c:chd4|CHD4]]|0.42|
|[[:human genes:p:pole|POLE]]|0.416|
|[[:human genes:p:polr2j3|POLR2J3]]|0.413|
|[[:human genes:n:nup160|NUP160]]|0.411|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 19/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|4/28|
|bone|1/26|
|breast|0/33|
|central nervous system|2/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|1/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|1/16|
|ovary|0/26|
|pancreas|1/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|2/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1089
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.51 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FTSJ3 Expression in NALM6 Cells: 7.51'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>