FURIN [The Human Chemical-Genetic Interaction Map Project]

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======= FURIN =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FURIN
  * **<color #00a2e8>Official Name</color>**: furin, paired basic amino acid cleaving enzyme
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5045|5045]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P09958|P09958]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FURIN&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FURIN|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/136950|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RX(K/R)R consensus motif. {ECO:0000269|PubMed:11799113, ECO:0000269|PubMed:1629222, ECO:0000269|PubMed:1713771, ECO:0000269|PubMed:2251280, ECO:0000269|PubMed:24666235, ECO:0000269|PubMed:25974265, ECO:0000269|PubMed:7592877, ECO:0000269|PubMed:7690548, ECO:0000269|PubMed:9130696}. (Microbial infection) Required for H7N1 and H5N1 influenza virus infection probably by cleaving hemagglutinin. {ECO:0000269|PubMed:25974265}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|P proprotein|
|Peptidase S8|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|dibasic protein processing|
|regulation of transforming growth factor beta1 activation|
|regulation of nerve growth factor production|
|positive regulation of transforming growth factor beta activation|
|viral protein processing|
|negative regulation of nerve growth factor production|
|positive regulation of transforming growth factor beta1 activation|
|neurotrophin production|
|nerve growth factor production|
|negative regulation of neurotrophin production|
|regulation of neurotrophin production|
|negative regulation of low-density lipoprotein particle receptor catabolic process|
|nerve growth factor processing|
|negative regulation of receptor catabolic process|
|nerve growth factor binding|
|negative regulation of transforming growth factor beta1 production|
|regulation of low-density lipoprotein particle receptor catabolic process|
|positive regulation of transforming growth factor beta1 production|
|regulation of transforming growth factor beta activation|
|negative regulation of transforming growth factor beta production|
|regulation of low-density lipoprotein particle receptor biosynthetic process|
|regulation of receptor catabolic process|
|regulation of transforming growth factor beta1 production|
|signal peptide processing|
|positive regulation of membrane protein ectodomain proteolysis|
|trans-Golgi network transport vesicle|
|positive regulation of transforming growth factor beta production|
|regulation of lipoprotein lipase activity|
|regulation of receptor biosynthetic process|
|regulation of membrane protein ectodomain proteolysis|
|peptide hormone processing|
|regulation of transforming growth factor beta production|
|zymogen activation|
|collagen catabolic process|
|peptide binding|
|integral component of Golgi membrane|
|collagen metabolic process|
|extracellular matrix disassembly|
|endopeptidase activity|
|peptidase activity|
|negative regulation of cellular protein catabolic process|
|serine-type endopeptidase inhibitor activity|
|regulation of lipase activity|
|Golgi lumen|
|protease binding|
|transforming growth factor beta receptor signaling pathway|
|cornification|
|viral gene expression|
|negative regulation of protein catabolic process|
|cellular response to transforming growth factor beta stimulus|
|protein processing|
|response to transforming growth factor beta|
|serine-type endopeptidase activity|
|trans-Golgi network|
|transmembrane receptor protein serine/threonine kinase signaling pathway|
|viral life cycle|
|hormone metabolic process|
|endosome membrane|
|positive regulation of protein catabolic process|
|membrane raft|
|protein maturation|
|keratinization|
|negative regulation of endopeptidase activity|
|regulation of cellular protein catabolic process|
|negative regulation of cellular catabolic process|
|negative regulation of peptidase activity|
|negative regulation of cytokine production|
|keratinocyte differentiation|
|negative regulation of catabolic process|
|epidermal cell differentiation|
|extracellular matrix organization|
|negative regulation of proteolysis|
|positive regulation of proteolysis|
|positive regulation of cellular catabolic process|
|skin development|
|regulation of protein catabolic process|
|extracellular structure organization|
|cellular component disassembly|
|peptide biosynthetic process|
|epidermis development|
|regulation of endopeptidase activity|
|positive regulation of catabolic process|
|regulation of peptidase activity|
|positive regulation of cytokine production|
|negative regulation of hydrolase activity|
|cellular response to growth factor stimulus|
|amide biosynthetic process|
|peptide metabolic process|
|response to growth factor|
|regulation of hormone levels|
|cell surface|
|Golgi membrane|
|epithelial cell differentiation|
|regulation of cytokine production|
|viral process|
|enzyme linked receptor protein signaling pathway|
|regulation of proteolysis|
|symbiotic process|
|cellular amide metabolic process|
|negative regulation of catalytic activity|
|interspecies interaction between organisms|
|regulation of cellular catabolic process|
|regulation of catabolic process|
|secretion by cell|
|endoplasmic reticulum|
|negative regulation of cellular protein metabolic process|
|export from cell|
|programmed cell death|
|cell death|
|negative regulation of protein metabolic process|
|epithelium development|
|secretion|
|negative regulation of molecular function|
|negative regulation of multicellular organismal process|
|cellular response to endogenous stimulus|
|proteolysis|
|regulation of hydrolase activity|
|organonitrogen compound biosynthetic process|
|response to endogenous stimulus|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|cellular nitrogen compound biosynthetic process|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|extracellular region|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|-2.35|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|-1.77|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 12/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|1/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|6/15|
|prostate|1/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5297
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.4 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FURIN Expression in NALM6 Cells: 3.4'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>