FUS [The Human Chemical-Genetic Interaction Map Project]

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======= FUS =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FUS
  * **<color #00a2e8>Official Name</color>**: FUS RNA binding protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2521|2521]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P35637|P35637]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FUS&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FUS|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/137070|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a multifunctional protein component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex. The hnRNP complex is involved in pre-mRNA splicing and the export of fully processed mRNA to the cytoplasm. This protein belongs to the FET family of RNA-binding proteins which have been implicated in cellular processes that include regulation of gene expression, maintenance of genomic integrity and mRNA/microRNA processing. Alternative splicing results in multiple transcript variants. Defects in this gene result in amyotrophic lateral sclerosis type 6. [provided by RefSeq, Sep 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Binds both single-stranded and double-stranded DNA and promotes ATP-independent annealing of complementary single- stranded DNAs and D-loop formation in superhelical double-stranded DNA. May play a role in maintenance of genomic integrity.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|zf-RanBP|
|RRM 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|dendritic spine head|
|positive regulation of double-strand break repair via homologous recombination|
|retinoid X receptor binding|
|myosin V binding|
|thyroid hormone receptor binding|
|positive regulation of double-strand break repair|
|ionotropic glutamate receptor binding|
|positive regulation of DNA recombination|
|estrogen receptor binding|
|polysome|
|regulation of double-strand break repair via homologous recombination|
|positive regulation of DNA repair|
|regulation of double-strand break repair|
|cellular response to calcium ion|
|positive regulation of response to DNA damage stimulus|
|regulation of DNA recombination|
|regulation of DNA repair|
|perikaryon|
|regulation of RNA splicing|
|response to calcium ion|
|cellular response to metal ion|
|positive regulation of DNA metabolic process|
|regulation of response to DNA damage stimulus|
|cellular response to inorganic substance|
|transcription coactivator activity|
|mRNA splicing, via spliceosome|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|RNA splicing, via transesterification reactions|
|protein homooligomerization|
|regulation of DNA metabolic process|
|response to metal ion|
|chromatin binding|
|RNA splicing|
|mRNA processing|
|protein complex oligomerization|
|response to inorganic substance|
|mRNA metabolic process|
|perinuclear region of cytoplasm|
|regulation of cellular response to stress|
|RNA processing|
|identical protein binding|
|RNA binding|
|DNA binding|
|regulation of response to stress|
|protein-containing complex assembly|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|RNA metabolic process|
|positive regulation of RNA metabolic process|
|protein-containing complex subunit organization|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp15|Cycloheximide 0.2μM R00 exp15]]|-1.84|
|[[:results:exp189|Temozolomide 200μM R04 exp189]]|-1.81|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|1.74|
|[[:results:exp134|MS023 2μM R03 exp134]]|1.77|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|1.92|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|1.93|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|1.95|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|2.17|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|2.25|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|2.32|
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|2.37|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|2.69|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|2.75|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:l:lsm12|LSM12]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10455
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 9.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FUS Expression in NALM6 Cells: 9.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>