FXR1 [The Human Chemical-Genetic Interaction Map Project]

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======= FXR1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FXR1
  * **<color #00a2e8>Official Name</color>**: FMR1 autosomal homolog 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8087|8087]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P51114|P51114]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FXR1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FXR1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600819|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|KH 1|
|FXR1P C|
|Agenet|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|RNA strand annealing activity|
|ribonucleoprotein granule|
|translation regulator activity|
|costamere|
|positive regulation of gene silencing by miRNA|
|positive regulation of posttranscriptional gene silencing|
|polysome|
|cytoplasmic ribonucleoprotein granule|
|mRNA 3-UTR binding|
|regulation of gene silencing by miRNA|
|regulation of gene silencing by RNA|
|regulation of posttranscriptional gene silencing|
|positive regulation of translation|
|regulation of gene silencing|
|negative regulation of translation|
|negative regulation of cellular amide metabolic process|
|dendritic spine|
|positive regulation of cellular amide metabolic process|
|mRNA binding|
|regulation of mRNA stability|
|regulation of RNA stability|
|regulation of mRNA catabolic process|
|postsynaptic density|
|axon|
|muscle organ development|
|regulation of mRNA metabolic process|
|glutamatergic synapse|
|regulation of translation|
|neuronal cell body|
|regulation of cellular amide metabolic process|
|muscle structure development|
|protein heterodimerization activity|
|posttranscriptional regulation of gene expression|
|perinuclear region of cytoplasm|
|regulation of cellular catabolic process|
|nucleolus|
|protein homodimerization activity|
|apoptotic process|
|regulation of catabolic process|
|negative regulation of cellular protein metabolic process|
|programmed cell death|
|cell death|
|negative regulation of protein metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|RNA binding|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|positive regulation of cellular protein metabolic process|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|membrane|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|-2.54|
|[[:results:exp355|Dinaciclib 0.007μM R07 exp355]]|-1.92|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|-1.76|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|1.74|
|[[:results:exp539|42°C R08 exp539]]|1.77|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|1.97|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8891
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.11 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FXR1 Expression in NALM6 Cells: 7.11'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>