FXYD1 [The Human Chemical-Genetic Interaction Map Project]

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======= FXYD1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FXYD1
  * **<color #00a2e8>Official Name</color>**: FXYD domain containing ion transport regulator 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5348|5348]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O00168|O00168]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FXYD1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FXYD1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602359|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which transports Na(+) out of the cell and K(+) into the cell. Inhibits NKA activity in its unphosphorylated state and stimulates activity when phosphorylated. Reduces glutathionylation of the NKA beta-1 subunit ATP1B1, thus reversing glutathionylation-mediated inhibition of ATP1B1. Contributes to female sexual development by maintaining the excitability of neurons which secrete gonadotropin-releasing hormone. {ECO:0000250|UniProtKB:O08589, ECO:0000250|UniProtKB:P56513, ECO:0000250|UniProtKB:Q9Z239}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ATP1G1 PLM MAT8|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of protein glutathionylation|
|negative regulation of protein glutathionylation|
|regulation of sodium ion export across plasma membrane|
|positive regulation of sodium ion export across plasma membrane|
|regulation of cardiac muscle cell membrane potential|
|ion channel regulator activity|
|sodium:potassium-exchanging ATPase complex|
|positive regulation of sodium ion transmembrane transport|
|positive regulation of sodium ion transport|
|sodium channel regulator activity|
|T-tubule|
|intercalated disc|
|regulation of sodium ion transmembrane transporter activity|
|chloride channel activity|
|regulation of sodium ion transmembrane transport|
|regulation of cardiac conduction|
|caveola|
|regulation of sodium ion transport|
|chloride transmembrane transport|
|sarcolemma|
|chloride transport|
|inorganic anion transmembrane transport|
|ion channel binding|
|positive regulation of cation transmembrane transport|
|sodium ion transport|
|positive regulation of ion transmembrane transport|
|inorganic anion transport|
|potassium ion transport|
|positive regulation of transmembrane transport|
|regulation of heart contraction|
|muscle contraction|
|regulation of ion transmembrane transporter activity|
|regulation of transmembrane transporter activity|
|positive regulation of ion transport|
|anion transmembrane transport|
|regulation of transporter activity|
|regulation of blood circulation|
|muscle system process|
|apical plasma membrane|
|regulation of cation transmembrane transport|
|regulation of metal ion transport|
|monovalent inorganic cation transport|
|regulation of membrane potential|
|regulation of ion transmembrane transport|
|regulation of transmembrane transport|
|anion transport|
|regulation of system process|
|negative regulation of protein modification process|
|metal ion transport|
|inorganic ion transmembrane transport|
|regulation of ion transport|
|cation transport|
|ion transmembrane transport|
|positive regulation of transport|
|negative regulation of cellular protein metabolic process|
|negative regulation of protein metabolic process|
|transmembrane transport|
|ion transport|
|integral component of plasma membrane|
|regulation of protein modification process|
|regulation of transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:prim1|PRIM1]]|0.411|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10930
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -6.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FXYD1 Expression in NALM6 Cells: -6.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>