FZD3 [The Human Chemical-Genetic Interaction Map Project]

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======= FZD3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FZD3
  * **<color #00a2e8>Official Name</color>**: frizzled class receptor 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7976|7976]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NPG1|Q9NPG1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FZD3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FZD3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606143|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. The function of this protein is unknown, although it may play a role in mammalian hair follicle development. Alternative splicing results in multiple transcript variants. This gene is a susceptibility locus for schizophrenia. [provided by RefSeq, Dec 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. Activation by Wnt5A stimulates PKC activity via a G-protein-dependent mechanism. Involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Plays a role in controlling early axon growth and guidance processes necessary for the formation of a subset of central and peripheral major fiber tracts. Required for the development of major fiber tracts in the central nervous system, including: the anterior commissure, the corpus callosum, the thalamocortical, corticothalamic and nigrostriatal tracts, the corticospinal tract, the fasciculus retroflexus, the mammillothalamic tract, the medial lemniscus, and ascending fiber tracts from the spinal cord to the brain. In the peripheral nervous system, controls axon growth in distinct populations of cranial and spinal motor neurons, including the facial branchimotor nerve, the hypoglossal nerve, the phrenic nerve, and motor nerves innervating dorsal limbs. Involved in the migration of cranial neural crest cells. May also be implicated in the transmission of sensory information from the trunk and limbs to the brain. Controls commissural sensory axons guidance after midline crossing along the anterior-posterior axis in the developing spinal cord in a Wnt-dependent signaling pathway. Together with FZD6, is involved in the neural tube closure and plays a role in the regulation of the establishment of planar cell polarity (PCP), particularly in the orientation of asymmetric bundles of stereocilia on the apical faces of a subset of auditory and vestibular sensory cells located in the inner ear. Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle in a beta-catenin-dependent manner (By similarity). {ECO:0000250|UniProtKB:Q61086}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Fz|
|Frizzled|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of mitotic cell cycle, embryonic|
|midbrain morphogenesis|
|serotonergic neuron axon guidance|
|regulation of mitotic cell cycle, embryonic|
|dopaminergic neuron axon guidance|
|planar cell polarity pathway involved in axon guidance|
|cell proliferation in midbrain|
|sympathetic ganglion development|
|commissural neuron axon guidance|
|ganglion development|
|Wnt-activated receptor activity|
|filopodium tip|
|post-anal tail morphogenesis|
|sympathetic nervous system development|
|positive regulation of neuroblast proliferation|
|establishment of planar polarity|
|establishment of tissue polarity|
|negative regulation of execution phase of apoptosis|
|negative regulation of embryonic development|
|regulation of neuroblast proliferation|
|brain morphogenesis|
|presynaptic active zone|
|Wnt signaling pathway, calcium modulating pathway|
|Wnt-protein binding|
|positive regulation of stem cell proliferation|
|regulation of execution phase of apoptosis|
|morphogenesis of a polarized epithelium|
|response to electrical stimulus|
|autonomic nervous system development|
|positive regulation of neural precursor cell proliferation|
|lateral plasma membrane|
|regulation of stem cell proliferation|
|hair follicle development|
|skin epidermis development|
|hair cycle process|
|molting cycle process|
|neural precursor cell proliferation|
|midbrain development|
|PDZ domain binding|
|regulation of neural precursor cell proliferation|
|canonical Wnt signaling pathway|
|neural tube closure|
|molting cycle|
|hair cycle|
|tube closure|
|Wnt signaling pathway, planar cell polarity pathway|
|inner ear morphogenesis|
|primary neural tube formation|
|neural tube formation|
|regulation of establishment of planar polarity|
|ear morphogenesis|
|neuron migration|
|embryonic epithelial tube formation|
|regulation of embryonic development|
|epithelial tube formation|
|non-canonical Wnt signaling pathway|
|morphogenesis of embryonic epithelium|
|tube formation|
|neural tube development|
|regulation of morphogenesis of an epithelium|
|inner ear development|
|ear development|
|sensory organ morphogenesis|
|regulation of animal organ morphogenesis|
|axon guidance|
|neuron projection guidance|
|embryonic organ morphogenesis|
|axon|
|epithelial tube morphogenesis|
|negative regulation of mitotic cell cycle|
|apical plasma membrane|
|Wnt signaling pathway|
|cell-cell signaling by wnt|
|axonogenesis|
|neuronal cell body|
|skin development|
|axon development|
|epidermis development|
|dendrite|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|morphogenesis of an epithelium|
|cell morphogenesis involved in neuron differentiation|
|embryonic organ development|
|positive regulation of neurogenesis|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|cell part morphogenesis|
|positive regulation of nervous system development|
|positive regulation of cell development|
|sensory organ development|
|chemotaxis|
|taxis|
|cell population proliferation|
|cell morphogenesis involved in differentiation|
|tissue morphogenesis|
|embryonic morphogenesis|
|negative regulation of cell cycle|
|cell surface|
|regulation of mitotic cell cycle|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|neuron projection development|
|cell morphogenesis|
|G protein-coupled receptor activity|
|brain development|
|head development|
|neuron development|
|regulation of neurogenesis|
|cellular component morphogenesis|
|tube development|
|negative regulation of apoptotic process|
|anatomical structure formation involved in morphogenesis|
|negative regulation of programmed cell death|
|positive regulation of cell population proliferation|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|animal organ morphogenesis|
|cell migration|
|positive regulation of cell differentiation|
|embryo development|
|central nervous system development|
|negative regulation of cell death|
|neuron differentiation|
|response to drug|
|regulation of anatomical structure morphogenesis|
|localization of cell|
|cell motility|
|epithelium development|
|cell-cell signaling|
|plasma membrane bounded cell projection organization|
|response to abiotic stimulus|
|cell projection organization|
|regulation of cell cycle|
|negative regulation of multicellular organismal process|
|locomotion|
|G protein-coupled receptor signaling pathway|
|positive regulation of developmental process|
|generation of neurons|
|regulation of apoptotic process|
|movement of cell or subcellular component|
|regulation of programmed cell death|
|regulation of cell population proliferation|
|neurogenesis|
|cell development|
|regulation of cell death|
|positive regulation of multicellular organismal process|
|tissue development|
|regulation of cell differentiation|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp51|Nifuroxazide 1μM R01 exp51]]|-1.81|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|-1.71|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|1.96|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.426|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18521
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.89 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FZD3 Expression in NALM6 Cells: 5.89'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>