FZD4 [The Human Chemical-Genetic Interaction Map Project]

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======= FZD4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FZD4
  * **<color #00a2e8>Official Name</color>**: frizzled class receptor 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8322|8322]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9ULV1|Q9ULV1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FZD4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FZD4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604579|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This protein may play a role as a positive regulator of the Wingless type MMTV integration site signaling pathway. A transcript variant retaining intronic sequence and encoding a shorter isoform has been described, however, its expression is not supported by other experimental evidence. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin (CTNNB1) canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin (CTNNB1) and activation of Wnt target genes. Plays a critical role in retinal vascularization by acting as a receptor for Wnt proteins and norrin (NDP). In retina, it can be both activated by Wnt protein-binding, but also by a Wnt-independent signaling via binding of norrin (NDP), promoting in both cases beta-catenin (CTNNB1) accumulation and stimulation of LEF/TCF-mediated transcriptional programs. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Frizzled|
|Fz|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cerebellum vasculature morphogenesis|
|progesterone secretion|
|cerebellum vasculature development|
|Norrin signaling pathway|
|extracellular matrix-cell signaling|
|lipid export from cell|
|steroid hormone secretion|
|retinal blood vessel morphogenesis|
|locomotion involved in locomotory behavior|
|luteinization|
|positive regulation of neuron projection arborization|
|retina vasculature morphogenesis in camera-type eye|
|regulation of neuron projection arborization|
|endocrine hormone secretion|
|retina vasculature development in camera-type eye|
|Wnt-activated receptor activity|
|regulation of vascular endothelial growth factor receptor signaling pathway|
|clathrin-coated endocytic vesicle membrane|
|Wnt signaling pathway, calcium modulating pathway|
|Wnt-protein binding|
|cytokine binding|
|ovulation cycle process|
|cytokine receptor activity|
|endocrine process|
|substrate adhesion-dependent cell spreading|
|clathrin-coated vesicle membrane|
|negative regulation of cell-substrate adhesion|
|ovulation cycle|
|vasculogenesis|
|cellular response to retinoic acid|
|positive regulation of JUN kinase activity|
|hormone secretion|
|amyloid-beta binding|
|hormone transport|
|regulation of JUN kinase activity|
|female gonad development|
|PDZ domain binding|
|canonical Wnt signaling pathway|
|development of primary female sexual characteristics|
|response to leukemia inhibitory factor|
|cellular response to leukemia inhibitory factor|
|Wnt signaling pathway, planar cell polarity pathway|
|cerebellum development|
|female sex differentiation|
|response to retinoic acid|
|regulation of establishment of planar polarity|
|metencephalon development|
|non-canonical Wnt signaling pathway|
|positive regulation of JNK cascade|
|retina development in camera-type eye|
|sensory perception of sound|
|drug transport|
|hindbrain development|
|positive regulation of stress-activated MAPK cascade|
|sensory perception of mechanical stimulus|
|positive regulation of stress-activated protein kinase signaling cascade|
|signal release|
|cell-cell junction|
|regulation of morphogenesis of an epithelium|
|cell-substrate adhesion|
|regulation of JNK cascade|
|locomotory behavior|
|signaling receptor activity|
|cellular response to acid chemical|
|gonad development|
|regulation of cell-substrate adhesion|
|development of primary sexual characteristics|
|regulation of stress-activated MAPK cascade|
|regulation of stress-activated protein kinase signaling cascade|
|regulation of animal organ morphogenesis|
|positive regulation of DNA-binding transcription factor activity|
|positive regulation of MAP kinase activity|
|sex differentiation|
|protein-containing complex binding|
|regulation of cellular response to growth factor stimulus|
|negative regulation of cell adhesion|
|rhythmic process|
|positive regulation of neuron projection development|
|ubiquitin protein ligase binding|
|lipid transport|
|camera-type eye development|
|lipid localization|
|positive regulation of protein serine/threonine kinase activity|
|regulation of MAP kinase activity|
|response to acid chemical|
|glutamatergic synapse|
|cellular process involved in reproduction in multicellular organism|
|Wnt signaling pathway|
|cell-cell signaling by wnt|
|eye development|
|visual system development|
|positive regulation of neuron differentiation|
|sensory system development|
|positive regulation of cell projection organization|
|blood vessel morphogenesis|
|dendrite|
|reproductive structure development|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|regulation of DNA-binding transcription factor activity|
|reproductive system development|
|positive regulation of neurogenesis|
|blood vessel development|
|protein heterodimerization activity|
|regulation of cell morphogenesis|
|regulation of neuron projection development|
|vasculature development|
|regulation of protein serine/threonine kinase activity|
|cardiovascular system development|
|cellular response to lipid|
|positive regulation of protein kinase activity|
|regulation of hormone levels|
|positive regulation of nervous system development|
|positive regulation of cell development|
|positive regulation of MAPK cascade|
|sensory organ development|
|cell morphogenesis involved in differentiation|
|behavior|
|positive regulation of kinase activity|
|cell surface|
|tube morphogenesis|
|regulation of neuron differentiation|
|positive regulation of transferase activity|
|developmental process involved in reproduction|
|cytokine-mediated signaling pathway|
|regulation of cell adhesion|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cell projection organization|
|cell morphogenesis|
|G protein-coupled receptor activity|
|regulation of cellular response to stress|
|brain development|
|regulation of MAPK cascade|
|head development|
|regulation of protein kinase activity|
|regulation of neurogenesis|
|cellular component morphogenesis|
|multicellular organismal reproductive process|
|multicellular organism reproduction|
|tube development|
|response to lipid|
|membrane organization|
|circulatory system development|
|regulation of kinase activity|
|protein homodimerization activity|
|regulation of nervous system development|
|cell adhesion|
|regulation of cell development|
|biological adhesion|
|positive regulation of cell differentiation|
|sensory perception|
|regulation of transferase activity|
|central nervous system development|
|secretion by cell|
|cellular response to cytokine stimulus|
|neuron differentiation|
|positive regulation of protein phosphorylation|
|response to drug|
|positive regulation of intracellular signal transduction|
|export from cell|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|response to cytokine|
|cell-cell signaling|
|secretion|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|positive regulation of cellular component organization|
|positive regulation of protein modification process|
|locomotion|
|G protein-coupled receptor signaling pathway|
|positive regulation of developmental process|
|nervous system process|
|integral component of plasma membrane|
|reproductive process|
|reproduction|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|regulation of response to stress|
|generation of neurons|
|positive regulation of transcription, DNA-templated|
|response to oxygen-containing compound|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cell development|
|positive regulation of signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|-1.96|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|1.89|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14799
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.78 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FZD4 Expression in NALM6 Cells: 1.78'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>