FZD7 [The Human Chemical-Genetic Interaction Map Project]

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======= FZD7 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FZD7
  * **<color #00a2e8>Official Name</color>**: frizzled class receptor 7
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8324|8324]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O75084|O75084]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FZD7&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FZD7|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603410|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Fz|
|Frizzled|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of ectoderm development|
|negative regulation of ectodermal cell fate specification|
|regulation of ectoderm development|
|regulation of ectodermal cell fate specification|
|skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration|
|non-canonical Wnt signaling pathway via JNK cascade|
|non-canonical Wnt signaling pathway via MAPK cascade|
|negative regulation of cell fate specification|
|negative regulation of gastrulation|
|positive regulation of epithelial cell proliferation involved in wound healing|
|regulation of cell fate specification|
|negative regulation of cell fate commitment|
|mesenchymal to epithelial transition|
|negative regulation of cardiac muscle cell differentiation|
|Wnt-activated receptor activity|
|negative regulation of cardiocyte differentiation|
|somatic stem cell division|
|negative regulation of embryonic development|
|regulation of cell fate commitment|
|negative regulation of cardiac muscle tissue development|
|stem cell division|
|skeletal muscle tissue regeneration|
|regulation of cardiac muscle cell differentiation|
|Wnt-protein binding|
|regulation of gastrulation|
|negative regulation of striated muscle cell differentiation|
|frizzled binding|
|T cell differentiation in thymus|
|negative regulation of striated muscle tissue development|
|negative regulation of muscle organ development|
|regulation of cardiocyte differentiation|
|negative regulation of muscle tissue development|
|substrate adhesion-dependent cell spreading|
|negative regulation of muscle cell differentiation|
|negative regulation of cell-substrate adhesion|
|tissue regeneration|
|cellular response to retinoic acid|
|phosphatidylinositol-4,5-bisphosphate binding|
|regulation of cardiac muscle tissue development|
|recycling endosome membrane|
|PDZ domain binding|
|canonical Wnt signaling pathway|
|Wnt signaling pathway, planar cell polarity pathway|
|regulation of striated muscle cell differentiation|
|response to retinoic acid|
|regulation of establishment of planar polarity|
|regulation of embryonic development|
|regulation of striated muscle tissue development|
|non-canonical Wnt signaling pathway|
|regulation of muscle tissue development|
|stem cell population maintenance|
|T cell differentiation|
|regulation of muscle organ development|
|maintenance of cell number|
|positive regulation of JNK cascade|
|regulation of muscle cell differentiation|
|regeneration|
|positive regulation of stress-activated MAPK cascade|
|positive regulation of stress-activated protein kinase signaling cascade|
|regulation of morphogenesis of an epithelium|
|cell-substrate adhesion|
|regulation of JNK cascade|
|positive regulation of epithelial cell proliferation|
|cellular response to acid chemical|
|regulation of cell-substrate adhesion|
|regulation of stress-activated MAPK cascade|
|T cell activation|
|regulation of stress-activated protein kinase signaling cascade|
|lymphocyte differentiation|
|regulation of animal organ morphogenesis|
|negative regulation of cell adhesion|
|regulation of canonical Wnt signaling pathway|
|leukocyte differentiation|
|regulation of epithelial cell proliferation|
|response to acid chemical|
|cell-cell signaling by wnt|
|Wnt signaling pathway|
|regulation of Wnt signaling pathway|
|lymphocyte activation|
|developmental growth|
|growth|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|wound healing|
|cell division|
|cellular response to lipid|
|positive regulation of MAPK cascade|
|hemopoiesis|
|cell morphogenesis involved in differentiation|
|response to wounding|
|hematopoietic or lymphoid organ development|
|immune system development|
|epithelial cell differentiation|
|regulation of cell adhesion|
|negative regulation of cell differentiation|
|cell morphogenesis|
|G protein-coupled receptor activity|
|regulation of cellular response to stress|
|regulation of MAPK cascade|
|cellular component morphogenesis|
|response to lipid|
|positive regulation of cell population proliferation|
|leukocyte activation|
|cell adhesion|
|biological adhesion|
|negative regulation of developmental process|
|neuron differentiation|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|cell activation|
|epithelium development|
|cell-cell signaling|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|negative regulation of multicellular organismal process|
|positive regulation of protein modification process|
|G protein-coupled receptor signaling pathway|
|regulation of protein phosphorylation|
|regulation of response to stress|
|generation of neurons|
|positive regulation of transcription, DNA-templated|
|response to oxygen-containing compound|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cell development|
|positive regulation of signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of RNA metabolic process|
|tissue development|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp399|Salubrinal 20μM R07 exp399]]|-1.73|
|[[:results:exp344|Chlorpromazine 10μM R07 exp344]]|1.88|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14733
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.06 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FZD7 Expression in NALM6 Cells: 3.06'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>