GALNT11 [The Human Chemical-Genetic Interaction Map Project]

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======= GALNT11 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GALNT11
  * **<color #00a2e8>Official Name</color>**: polypeptide N-acetylgalactosaminyltransferase 11
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=63917|63917]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8NCW6|Q8NCW6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GALNT11&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GALNT11|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/615130|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Polypeptide N-acetylgalactosaminyltransferase that catalyzes the initiation of protein O-linked glycosylation and is involved in left/right asymmetry by mediating O-glycosylation of NOTCH1. O-glycosylation of NOTCH1 promotes activation of NOTCH1, modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO). Polypeptide N- acetylgalactosaminyltransferases catalyze the transfer of an N- acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Displays the same enzyme activity toward MUC1, MUC4, and EA2 than GALNT1. Not involved in glycosylation of erythropoietin (EPO). {ECO:0000269|PubMed:11925450, ECO:0000269|PubMed:24226769}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ricin B lectin|
|Glycos transf 2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein O-linked glycosylation via threonine|
|Notch receptor processing|
|Notch signaling involved in heart development|
|polypeptide N-acetylgalactosaminyltransferase activity|
|cell surface receptor signaling pathway involved in heart development|
|Notch binding|
|O-glycan processing|
|peptidyl-threonine modification|
|regulation of Notch signaling pathway|
|protein O-linked glycosylation|
|determination of left/right symmetry|
|determination of bilateral symmetry|
|specification of symmetry|
|Notch signaling pathway|
|carbohydrate binding|
|macromolecule glycosylation|
|protein glycosylation|
|glycosylation|
|glycoprotein biosynthetic process|
|cilium assembly|
|cilium organization|
|glycoprotein metabolic process|
|pattern specification process|
|plasma membrane bounded cell projection assembly|
|cell projection assembly|
|heart development|
|carbohydrate derivative biosynthetic process|
|Golgi membrane|
|organelle assembly|
|circulatory system development|
|peptidyl-amino acid modification|
|Golgi apparatus|
|carbohydrate derivative metabolic process|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|organonitrogen compound biosynthetic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|-2.28|
|[[:results:exp42|BI-6727 0.001μM R01 exp42]]|-1.81|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10828
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.25 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GALNT11 Expression in NALM6 Cells: 2.25'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>