GANAB [The Human Chemical-Genetic Interaction Map Project]

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======= GANAB =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GANAB
  * **<color #00a2e8>Official Name</color>**: glucosidase II alpha subunit
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23193|23193]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q14697|Q14697]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GANAB&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GANAB|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/104160|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes the alpha subunit of glucosidase II and a member of the glycosyl hydrolase 31 family of proteins. The heterodimeric enzyme glucosidase II plays a role in protein folding and quality control by cleaving glucose residues from immature glycoproteins in the endoplasmic reticulum. Expression of the encoded protein is elevated in lung tumor tissue and in response to UV irradiation. Mutations in this gene cause autosomal-dominant polycystic kidney and liver disease. [provided by RefSeq, Jul 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins (PubMed:10929008). Required for PKD1/Polycystin-1 and PKD2/Polycystin-2 maturation and localization to the cell surface and cilia (PubMed:27259053). {ECO:0000269|PubMed:10929008, ECO:0000269|PubMed:27259053}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Glyco hydro 31|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|alpha-glucosidase activity|
|glucan 1,3-alpha-glucosidase activity|
|glucosidase II complex|
|N-glycan processing|
|melanosome|
|carbohydrate binding|
|protein folding|
|endoplasmic reticulum lumen|
|glycoprotein metabolic process|
|carbohydrate metabolic process|
|intracellular membrane-bounded organelle|
|Golgi apparatus|
|carbohydrate derivative metabolic process|
|RNA binding|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp292|Menadione 5μM R06 exp292]]|1.84|
|[[:results:exp116|AICAR 240μM R03 exp116]]|1.9|
|[[:results:exp59|UMK57 1μM R01 exp59]]|1.9|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|1.95|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|2|
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|2|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|2.12|
|[[:results:exp525|Sulforaphane 9μM R08 exp525]]|2.16|
|[[:results:exp400|Senexin-A 25μM R07 exp400]]|2.17|
|[[:results:exp526|Sulforaphane 9μM R08 exp526 no dilution day6]]|2.19|
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|2.23|
|[[:results:exp390|Pifithrin-alpha 20μM R07 exp390]]|2.23|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|2.31|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|2.36|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|2.43|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|3.37|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|3.49|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:prkcsh|PRKCSH]]|0.527|
|[[:human genes:c:cd19|CD19]]|0.517|
|[[:human genes:s:syk|SYK]]|0.501|
|[[:human genes:i:igll1|IGLL1]]|0.484|
|[[:human genes:c:cd79b|CD79B]]|0.453|
|[[:human genes:r:rhoh|RHOH]]|0.443|
|[[:human genes:c:cd79a|CD79A]]|0.442|
|[[:human genes:p:pik3cd|PIK3CD]]|0.405|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 4/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1997
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 9.2 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GANAB Expression in NALM6 Cells: 9.2'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>