GAS6 [The Human Chemical-Genetic Interaction Map Project]

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======= GAS6 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GAS6
  * **<color #00a2e8>Official Name</color>**: growth arrest specific 6
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2621|2621]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q14393|Q14393]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GAS6&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GAS6|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600441|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a gamma-carboxyglutamic acid (Gla)-containing protein thought to be involved in the stimulation of cell proliferation. This gene is frequently overexpressed in many cancers and has been implicated as an adverse prognostic marker. Elevated protein levels are additionally associated with a variety of disease states, including venous thromboembolic disease, systemic lupus erythematosus, chronic renal failure, and preeclampsia. [provided by RefSeq, Aug 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. {ECO:0000269|PubMed:12364394, ECO:0000269|PubMed:18840707}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Laminin G 2|
|cEGF|
|Gla|
|EGF CA|
|Laminin G 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of oligodendrocyte apoptotic process|
|negative regulation of renal albumin absorption|
|cellular response to vitamin K|
|regulation of renal albumin absorption|
|macrophage cytokine production|
|regulation of oligodendrocyte apoptotic process|
|hematopoietic stem cell migration to bone marrow|
|response to vitamin K|
|hematopoietic stem cell migration|
|positive regulation of glomerular filtration|
|myeloid leukocyte cytokine production|
|receptor-mediated virion attachment to host cell|
|B cell chemotaxis|
|multi-organism membrane fusion|
|membrane fusion involved in viral entry into host cell|
|fusion of virus membrane with host plasma membrane|
|negative regulation of fibroblast apoptotic process|
|negative regulation of dendritic cell apoptotic process|
|positive regulation of natural killer cell differentiation|
|negative regulation of glial cell apoptotic process|
|positive regulation of dendritic cell chemotaxis|
|regulation of dendritic cell chemotaxis|
|regulation of glial cell apoptotic process|
|multi-organism membrane organization|
|regulation of dendritic cell apoptotic process|
|protein tyrosine kinase activator activity|
|virion attachment to host cell|
|adhesion of symbiont to host cell|
|negative regulation of interleukin-6 secretion|
|cellular response to interferon-alpha|
|regulation of glomerular filtration|
|regulation of natural killer cell differentiation|
|adhesion of symbiont to host|
|renal system process involved in regulation of blood volume|
|regulation of fibroblast apoptotic process|
|negative regulation of interleukin-1 secretion|
|extracellular matrix assembly|
|positive regulation of natural killer cell activation|
|positive regulation of protein export from nucleus|
|response to interferon-alpha|
|negative regulation of tumor necrosis factor-mediated signaling pathway|
|multi-organism cellular process|
|cytokine production involved in immune response|
|cellular response to vitamin|
|renal system process involved in regulation of systemic arterial blood pressure|
|cysteine-type endopeptidase inhibitor activity involved in apoptotic process|
|viral genome replication|
|negative regulation of biomineral tissue development|
|negative regulation of biomineralization|
|negative regulation of endothelial cell apoptotic process|
|activation of protein kinase B activity|
|regulation of natural killer cell activation|
|dendritic cell differentiation|
|negative regulation of interleukin-1 production|
|negative regulation of interferon-gamma production|
|receptor ligand activity|
|regulation of renal system process|
|regulation of protein export from nucleus|
|protein kinase B signaling|
|positive regulation of TOR signaling|
|apoptotic cell clearance|
|voltage-gated calcium channel activity|
|negative regulation of epithelial cell apoptotic process|
|negative regulation of interleukin-6 production|
|platelet aggregation|
|negative regulation of leukocyte apoptotic process|
|lymphocyte chemotaxis|
|positive regulation of cytokine-mediated signaling pathway|
|regulation of endothelial cell apoptotic process|
|positive regulation of fibroblast proliferation|
|regulation of interleukin-1 secretion|
|positive regulation of protein tyrosine kinase activity|
|receptor tyrosine kinase binding|
|positive regulation of response to cytokine stimulus|
|regulation of tumor necrosis factor-mediated signaling pathway|
|phosphatidylserine binding|
|homotypic cell-cell adhesion|
|negative regulation of tumor necrosis factor production|
|negative regulation of cytokine-mediated signaling pathway|
|negative regulation of tumor necrosis factor superfamily cytokine production|
|positive regulation of nucleocytoplasmic transport|
|negative regulation of response to cytokine stimulus|
|platelet alpha granule lumen|
|lymphocyte migration|
|cellular response to nutrient|
|negative regulation of cytokine secretion|
|positive regulation of phagocytosis|
|cellular response to glucose stimulus|
|cellular response to hexose stimulus|
|cellular response to monosaccharide stimulus|
|animal organ regeneration|
|regulation of epithelial cell apoptotic process|
|protein binding, bridging|
|cellular response to carbohydrate stimulus|
|regulation of fibroblast proliferation|
|regulation of leukocyte apoptotic process|
|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|response to vitamin|
|positive regulation of leukocyte chemotaxis|
|cellular glucose homeostasis|
|regulation of protein tyrosine kinase activity|
|negative regulation of cysteine-type endopeptidase activity|
|regulation of biomineralization|
|regulation of biomineral tissue development|
|regulation of systemic arterial blood pressure|
|positive regulation of lymphocyte differentiation|
|regulation of interleukin-1 production|
|viral entry into host cell|
|regulation of phagocytosis|
|regulation of interferon-gamma production|
|Golgi lumen|
|entry into host cell|
|regulation of TOR signaling|
|entry into host|
|positive regulation of peptidyl-serine phosphorylation|
|regulation of nucleocytoplasmic transport|
|renal system process|
|regulation of leukocyte chemotaxis|
|neuron migration|
|platelet degranulation|
|positive regulation of leukocyte migration|
|membrane fusion|
|negative regulation of protein secretion|
|positive regulation of chemotaxis|
|regulation of peptidyl-serine phosphorylation|
|response to glucose|
|platelet activation|
|negative regulation of peptide secretion|
|regulation of interleukin-6 production|
|response to hexose|
|leukocyte chemotaxis|
|cell cycle arrest|
|positive regulation of leukocyte differentiation|
|response to monosaccharide|
|regulation of tumor necrosis factor production|
|cytokine production|
|cellular response to starvation|
|regulation of tumor necrosis factor superfamily cytokine production|
|positive regulation of intracellular protein transport|
|interaction with host|
|regeneration|
|negative regulation of DNA-binding transcription factor activity|
|regulation of cytokine-mediated signaling pathway|
|positive regulation of protein kinase B signaling|
|regulation of lymphocyte differentiation|
|response to carbohydrate|
|peptidyl-serine phosphorylation|
|regulation of response to cytokine stimulus|
|production of molecular mediator of immune response|
|regulation of blood pressure|
|negative regulation of protein transport|
|protein localization to plasma membrane|
|glucose homeostasis|
|cell-substrate adhesion|
|carbohydrate homeostasis|
|negative regulation of establishment of protein localization|
|positive regulation of hemopoiesis|
|positive regulation of peptidyl-tyrosine phosphorylation|
|response to starvation|
|regulation of leukocyte migration|
|calcium ion transmembrane transport|
|peptidyl-serine modification|
|viral life cycle|
|negative regulation of secretion by cell|
|regulation of cytokine secretion|
|positive regulation of intracellular transport|
|cell chemotaxis|
|positive regulation of ERK1 and ERK2 cascade|
|regulation of chemotaxis|
|endoplasmic reticulum to Golgi vesicle-mediated transport|
|response to nutrient|
|regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|regulation of protein kinase B signaling|
|protein localization to cell periphery|
|regulation of intracellular protein transport|
|negative regulation of secretion|
|cellular response to nutrient levels|
|regulation of cysteine-type endopeptidase activity|
|negative regulation of endopeptidase activity|
|calcium ion transport|
|regulation of peptidyl-tyrosine phosphorylation|
|negative regulation of peptidase activity|
|cellular response to extracellular stimulus|
|regulation of leukocyte differentiation|
|negative regulation of cytokine production|
|blood coagulation|
|regulation of ERK1 and ERK2 cascade|
|coagulation|
|divalent metal ion transport|
|hemostasis|
|divalent inorganic cation transport|
|endoplasmic reticulum lumen|
|positive regulation of cellular protein localization|
|activation of protein kinase activity|
|phagocytosis|
|leukocyte differentiation|
|signaling receptor binding|
|cellular response to external stimulus|
|extracellular matrix organization|
|regulation of intracellular transport|
|negative regulation of proteolysis|
|positive regulation of lymphocyte activation|
|post-translational protein modification|
|Golgi vesicle transport|
|leukocyte migration|
|extracellular structure organization|
|blood circulation|
|circulatory system process|
|positive regulation of leukocyte activation|
|cellular response to drug|
|positive regulation of cell activation|
|regulation of endopeptidase activity|
|positive regulation of protein transport|
|regulation of DNA-binding transcription factor activity|
|regulation of peptidase activity|
|regulation of hemopoiesis|
|negative regulation of hydrolase activity|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|wound healing|
|protein localization to membrane|
|negative regulation of transport|
|regulation of peptide secretion|
|regulation of body fluid levels|
|response to nutrient levels|
|positive regulation of cell migration|
|cellular response to growth factor stimulus|
|cell-cell adhesion|
|regulation of lymphocyte activation|
|positive regulation of cell motility|
|response to growth factor|
|response to extracellular stimulus|
|positive regulation of protein kinase activity|
|positive regulation of cellular component movement|
|regulation of cellular protein localization|
|positive regulation of MAPK cascade|
|regulation of vesicle-mediated transport|
|chemotaxis|
|taxis|
|positive regulation of locomotion|
|cell population proliferation|
|hemopoiesis|
|inorganic cation transmembrane transport|
|response to wounding|
|negative regulation of cell cycle|
|positive regulation of kinase activity|
|regulation of system process|
|regulation of leukocyte activation|
|positive regulation of response to external stimulus|
|hematopoietic or lymphoid organ development|
|cation transmembrane transport|
|metal ion transport|
|regulation of cell activation|
|inorganic ion transmembrane transport|
|immune system development|
|positive regulation of transferase activity|
|regulation of growth|
|regulation of cytokine production|
|viral process|
|regulated exocytosis|
|regulation of protein transport|
|enzyme linked receptor protein signaling pathway|
|calcium ion binding|
|regulation of proteolysis|
|regulation of peptide transport|
|cellular chemical homeostasis|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of MAPK cascade|
|symbiotic process|
|negative regulation of catalytic activity|
|exocytosis|
|regulation of protein kinase activity|
|regulation of secretion|
|interspecies interaction between organisms|
|cation transport|
|regulation of cell migration|
|membrane organization|
|regulation of kinase activity|
|peptidyl-amino acid modification|
|negative regulation of apoptotic process|
|cellular homeostasis|
|negative regulation of programmed cell death|
|regulation of cell motility|
|regulation of cellular localization|
|positive regulation of cell population proliferation|
|apoptotic process|
|cell adhesion|
|biological adhesion|
|negative regulation of developmental process|
|ion transmembrane transport|
|cell migration|
|positive regulation of cell differentiation|
|protein phosphorylation|
|regulation of transferase activity|
|regulation of locomotion|
|positive regulation of transport|
|regulation of cellular component movement|
|negative regulation of cell death|
|cell cycle process|
|secretion by cell|
|cellular response to cytokine stimulus|
|positive regulation of protein phosphorylation|
|response to drug|
|positive regulation of intracellular signal transduction|
|regulation of protein localization|
|negative regulation of cellular protein metabolic process|
|export from cell|
|programmed cell death|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|cell activation|
|cell motility|
|localization of cell|
|cell death|
|regulation of response to external stimulus|
|response to cytokine|
|negative regulation of protein metabolic process|
|chemical homeostasis|
|secretion|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|negative regulation of molecular function|
|positive regulation of immune system process|
|regulation of cell cycle|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|positive regulation of protein modification process|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of signal transduction|
|regulation of hydrolase activity|
|transmembrane transport|
|phosphorylation|
|locomotion|
|negative regulation of RNA metabolic process|
|cell cycle|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|ion transport|
|negative regulation of cellular macromolecule biosynthetic process|
|positive regulation of catalytic activity|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of protein phosphorylation|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|intracellular transport|
|generation of neurons|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|cellular protein localization|
|regulation of phosphorylation|
|extracellular space|
|cellular macromolecule localization|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|neurogenesis|
|homeostatic process|
|positive regulation of signal transduction|
|regulation of immune system process|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|establishment of localization in cell|
|regulation of protein modification process|
|regulation of transport|
|immune response|
|extracellular region|
|vesicle-mediated transport|
|system process|
|positive regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6970
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.41 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GAS6 Expression in NALM6 Cells: 0.41'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>