GATA2 [The Human Chemical-Genetic Interaction Map Project]

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======= GATA2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GATA2
  * **<color #00a2e8>Official Name</color>**: GATA binding protein 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2624|2624]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P23769|P23769]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GATA2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GATA2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/137295|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the GATA family of zinc-finger transcription factors that are named for the consensus nucleotide sequence they bind in the promoter regions of target genes. The encoded protein plays an essential role in regulating transcription of genes involved in the development and proliferation of hematopoietic and endocrine cell lineages. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Transcriptional activator which regulates endothelin-1 gene expression in endothelial cells. Binds to the consensus sequence 5'-AGATAG-3'.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|GATA|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of primitive erythrocyte differentiation|
|eosinophil fate commitment|
|eosinophil differentiation|
|regulation of forebrain neuron differentiation|
|negative regulation of fat cell proliferation|
|positive regulation of megakaryocyte differentiation|
|negative regulation of macrophage differentiation|
|commitment of neuronal cell to specific neuron type in forebrain|
|positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis|
|semicircular canal development|
|regulation of fat cell proliferation|
|forebrain neuron fate commitment|
|positive regulation of membrane invagination|
|positive regulation of phagocytosis, engulfment|
|regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis|
|GABAergic neuron differentiation|
|positive regulation of mast cell degranulation|
|C2H2 zinc finger domain binding|
|regulation of phagocytosis, engulfment|
|positive regulation of mast cell activation involved in immune response|
|regulation of membrane invagination|
|definitive hemopoiesis|
|ventral spinal cord interneuron differentiation|
|granulocyte differentiation|
|cell differentiation in hindbrain|
|positive regulation of mast cell activation|
|regulation of macrophage differentiation|
|positive regulation of cell migration involved in sprouting angiogenesis|
|negative regulation of neural precursor cell proliferation|
|enhancer sequence-specific DNA binding|
|positive regulation of leukocyte degranulation|
|positive regulation of erythrocyte differentiation|
|negative regulation of endothelial cell apoptotic process|
|homeostasis of number of cells within a tissue|
|positive regulation of pri-miRNA transcription by RNA polymerase II|
|positive regulation of myeloid leukocyte mediated immunity|
|regulation of mast cell degranulation|
|regulation of mast cell activation involved in immune response|
|regulation of cell migration involved in sprouting angiogenesis|
|cell fate determination|
|positive regulation of sprouting angiogenesis|
|regulation of pri-miRNA transcription by RNA polymerase II|
|pituitary gland development|
|negative regulation of Notch signaling pathway|
|negative regulation of epithelial cell apoptotic process|
|regulation of mast cell activation|
|negative regulation of myeloid leukocyte differentiation|
|negative regulation of fat cell differentiation|
|regulation of erythrocyte differentiation|
|ventral spinal cord development|
|regulation of leukocyte degranulation|
|regulation of endothelial cell apoptotic process|
|forebrain neuron differentiation|
|cochlea development|
|positive regulation of regulated secretory pathway|
|regulation of megakaryocyte differentiation|
|cell differentiation in spinal cord|
|positive regulation of blood vessel endothelial cell migration|
|regulation of histone acetylation|
|regulation of myeloid leukocyte mediated immunity|
|regulation of peptidyl-lysine acetylation|
|neuron fate commitment|
|somatic stem cell population maintenance|
|forebrain generation of neurons|
|positive regulation of phagocytosis|
|regulation of sprouting angiogenesis|
|regulation of protein acetylation|
|regulation of hematopoietic stem cell differentiation|
|diencephalon development|
|negative regulation of myeloid cell differentiation|
|regulation of epithelial cell apoptotic process|
|central nervous system neuron development|
|regulation of hematopoietic progenitor cell differentiation|
|embryonic placenta development|
|regulation of neural precursor cell proliferation|
|positive regulation of exocytosis|
|regulation of blood vessel endothelial cell migration|
|positive regulation of myeloid cell differentiation|
|positive regulation of endothelial cell proliferation|
|regulation of phagocytosis|
|inner ear morphogenesis|
|positive regulation of endothelial cell migration|
|RNA polymerase II distal enhancer sequence-specific DNA binding|
|positive regulation of endocytosis|
|negative regulation of leukocyte differentiation|
|regulation of Notch signaling pathway|
|spinal cord development|
|myeloid leukocyte differentiation|
|regulation of myeloid leukocyte differentiation|
|ear morphogenesis|
|regulation of stem cell differentiation|
|neuron migration|
|endocrine system development|
|regulation of fat cell differentiation|
|regulation of endothelial cell proliferation|
|regulation of embryonic development|
|positive regulation of leukocyte mediated immunity|
|stem cell population maintenance|
|maintenance of cell number|
|negative regulation of hemopoiesis|
|positive regulation of epithelial cell migration|
|regulation of histone modification|
|hindbrain development|
|placenta development|
|regulation of endothelial cell migration|
|cell maturation|
|regulation of regulated secretory pathway|
|positive regulation of angiogenesis|
|central nervous system neuron differentiation|
|positive regulation of vasculature development|
|positive regulation of hemopoiesis|
|regulation of chromatin organization|
|positive regulation of epithelial cell proliferation|
|tissue homeostasis|
|inner ear development|
|homeostasis of number of cells|
|regulation of endocytosis|
|regulation of leukocyte mediated immunity|
|positive regulation of intracellular transport|
|positive regulation of immune effector process|
|regulation of epithelial cell migration|
|myeloid cell differentiation|
|ear development|
|regulation of exocytosis|
|regulation of myeloid cell differentiation|
|developmental maturation|
|cell fate commitment|
|sensory organ morphogenesis|
|regulation of leukocyte differentiation|
|positive regulation of cytosolic calcium ion concentration|
|regulation of angiogenesis|
|embryonic organ morphogenesis|
|blood coagulation|
|coagulation|
|hemostasis|
|urogenital system development|
|regulation of vasculature development|
|multicellular organismal homeostasis|
|regulation of cytosolic calcium ion concentration|
|phagocytosis|
|leukocyte differentiation|
|transcription factor binding|
|regulation of epithelial cell proliferation|
|anatomical structure homeostasis|
|regulation of chromosome organization|
|regulation of intracellular transport|
|positive regulation of neuron differentiation|
|in utero embryonic development|
|forebrain development|
|chromatin binding|
|positive regulation of secretion by cell|
|positive regulation of leukocyte activation|
|gland development|
|positive regulation of cell activation|
|reproductive structure development|
|reproductive system development|
|embryonic organ development|
|positive regulation of secretion|
|cellular calcium ion homeostasis|
|negative regulation of immune system process|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|calcium ion homeostasis|
|regulation of hemopoiesis|
|regulation of immune effector process|
|cellular divalent inorganic cation homeostasis|
|positive regulation of neurogenesis|
|wound healing|
|divalent inorganic cation homeostasis|
|regulation of body fluid levels|
|positive regulation of cell migration|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|positive regulation of cell motility|
|positive regulation of nervous system development|
|positive regulation of cellular component movement|
|positive regulation of cell development|
|sensory organ development|
|regulation of vesicle-mediated transport|
|positive regulation of locomotion|
|cellular metal ion homeostasis|
|hemopoiesis|
|embryonic morphogenesis|
|response to wounding|
|protein-containing complex|
|regulation of leukocyte activation|
|hematopoietic or lymphoid organ development|
|metal ion homeostasis|
|cellular cation homeostasis|
|chordate embryonic development|
|transcription, DNA-templated|
|regulation of cell activation|
|nucleic acid-templated transcription|
|cellular ion homeostasis|
|immune system development|
|embryo development ending in birth or egg hatching|
|RNA biosynthetic process|
|regulation of neuron differentiation|
|developmental process involved in reproduction|
|DNA-binding transcription factor activity|
|negative regulation of cell population proliferation|
|cation homeostasis|
|negative regulation of cell differentiation|
|inorganic ion homeostasis|
|brain development|
|cellular chemical homeostasis|
|regulation of secretion by cell|
|head development|
|ion homeostasis|
|regulation of secretion|
|neuron development|
|regulation of neurogenesis|
|zinc ion binding|
|tube development|
|regulation of cell migration|
|response to lipid|
|negative regulation of transcription by RNA polymerase II|
|positive regulation of immune response|
|negative regulation of apoptotic process|
|cellular homeostasis|
|negative regulation of programmed cell death|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|regulation of cellular localization|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|animal organ morphogenesis|
|cell migration|
|positive regulation of cell differentiation|
|embryo development|
|central nervous system development|
|regulation of locomotion|
|positive regulation of transport|
|negative regulation of cell death|
|regulation of cellular component movement|
|neuron differentiation|
|regulation of anatomical structure morphogenesis|
|localization of cell|
|cell motility|
|nucleobase-containing compound biosynthetic process|
|chemical homeostasis|
|positive regulation of immune system process|
|regulation of immune response|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of signal transduction|
|regulation of organelle organization|
|organic cyclic compound biosynthetic process|
|locomotion|
|negative regulation of RNA metabolic process|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|reproductive process|
|reproduction|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|generation of neurons|
|positive regulation of transcription, DNA-templated|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|movement of cell or subcellular component|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of programmed cell death|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|neurogenesis|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|cell development|
|regulation of immune system process|
|RNA metabolic process|
|regulation of cell death|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|macromolecule biosynthetic process|
|regulation of cell differentiation|
|regulation of protein modification process|
|regulation of transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|vesicle-mediated transport|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp53|Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53]]|-2|
|[[:results:exp506|Momordin-Ic 10μM R08 exp506]]|1.87|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|1/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4547
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -6.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GATA2 Expression in NALM6 Cells: -6.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>