GATAD2A [The Human Chemical-Genetic Interaction Map Project]

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======= GATAD2A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GATAD2A
  * **<color #00a2e8>Official Name</color>**: GATA zinc finger domain containing 2A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=54815|54815]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q86YP4|Q86YP4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GATAD2A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GATAD2A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/614997|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Transcriptional repressor. Enhances MBD2-mediated repression. Efficient repression requires the presence of GATAD2B. {ECO:0000269|PubMed:12183469, ECO:0000269|PubMed:16415179}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|NuRD complex|
|DNA alkylation|
|DNA methylation|
|DNA methylation or demethylation|
|protein binding, bridging|
|DNA modification|
|macromolecule methylation|
|methylation|
|nuclear speck|
|sequence-specific DNA binding|
|DNA metabolic process|
|zinc ion binding|
|negative regulation of transcription by RNA polymerase II|
|negative regulation of transcription, DNA-templated|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|negative regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|-2.47|
|[[:results:exp306|Rapamycin 2μM R07 exp306]]|-2.21|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|-2.15|
|[[:results:exp418|Tunicamycin 0.04μM R07 exp418]]|-2.06|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|-1.93|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|-1.87|
|[[:results:exp400|Senexin-A 25μM R07 exp400]]|-1.84|
|[[:results:exp90|WYE-354 6μM R02 exp90]]|-1.74|
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|-1.73|
|[[:results:exp436|Dynasore 7μM R08 exp436]]|1.81|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|1.94|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|1.96|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|2.79|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|3.14|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:mta2|MTA2]]|0.476|
|[[:human genes:m:mbd3|MBD3]]|0.431|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 6/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|1/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5459
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.17 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GATAD2A Expression in NALM6 Cells: 7.17'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>