GATAD2B [The Human Chemical-Genetic Interaction Map Project]

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======= GATAD2B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GATAD2B
  * **<color #00a2e8>Official Name</color>**: GATA zinc finger domain containing 2B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=57459|57459]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8WXI9|Q8WXI9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GATAD2B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GATAD2B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/614998|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a zinc finger protein transcriptional repressor. The encoded protein is part of the methyl-CpG-binding protein-1 complex, which represses gene expression by deacetylating methylated nucleosomes. Mutations in this gene are linked to intellectual disability and dysmorphic features associated with cognitive disability. [provided by RefSeq, Jun 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Transcriptional repressor. Enhances MBD2-mediated repression. Efficient repression requires the presence of GATAD2A. Targets MBD3 to discrete loci in the nucleus. May play a role in synapse development. {ECO:0000269|PubMed:12183469, ECO:0000269|PubMed:16415179}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|GATA|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|NuRD complex|
|nucleosomal DNA binding|
|ATP-dependent chromatin remodeling|
|RNA polymerase II distal enhancer sequence-specific DNA binding|
|chromatin remodeling|
|nuclear chromatin|
|nuclear speck|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|protein-containing complex|
|chromatin organization|
|zinc ion binding|
|negative regulation of transcription by RNA polymerase II|
|chromosome organization|
|negative regulation of transcription, DNA-templated|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|negative regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|-2.22|
|[[:results:exp101|Nicotinamide 1000μM R03 exp101]]|-2.17|
|[[:results:exp419|Tunicamycin 0.04 to 0.075μM  on day4 R07 exp419]]|-1.82|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|-1.74|
|[[:results:exp331|A-769662 20μM R07 exp331]]|-1.73|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|1.81|
|[[:results:exp238|Parthenolide 2.5μM R05 exp238]]|1.87|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|1.94|
|[[:results:exp326|CCT251545 20μM R07 exp326]]|1.95|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|2.04|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|2.15|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|2.29|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|2.64|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:mbd3|MBD3]]|0.408|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14921
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.61 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GATAD2B Expression in NALM6 Cells: 6.61'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>