GBA3 [The Human Chemical-Genetic Interaction Map Project]

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======= GBA3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GBA3
  * **<color #00a2e8>Official Name</color>**: glucosylceramidase beta 3 (gene/pseudogene)
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=57733|57733]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H227|Q9H227]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GBA3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GBA3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606619|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Glycosidase probably involved in the intestinal absorption and metabolism of dietary flavonoid glycosides. Able to hydrolyze a broad variety of glycosides including phytoestrogens, flavonols, flavones, flavanones and cyanogens. Possesses beta- glycosylceramidase activity and may be involved in a nonlysosomal catabolic pathway of glycosylceramide. {ECO:0000269|PubMed:11784319, ECO:0000269|PubMed:12594539, ECO:0000269|PubMed:17595169}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Glyco hydro 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of exo-alpha-sialidase activity|
|scopolin beta-glucosidase activity|
|galactosylceramidase activity|
|beta-glucoside catabolic process|
|cellular oligosaccharide metabolic process|
|glycosylceramidase activity|
|beta-glucoside metabolic process|
|cellular oligosaccharide catabolic process|
|glucosylceramide catabolic process|
|galactosylceramide catabolic process|
|glucosylceramidase activity|
|regulation of exo-alpha-sialidase activity|
|galactolipid catabolic process|
|beta-glucosidase activity|
|beta-galactosidase activity|
|glycosylceramide catabolic process|
|glucosylceramide metabolic process|
|catalytic complex|
|glycoside catabolic process|
|galactosylceramide metabolic process|
|galactolipid metabolic process|
|oligosaccharide catabolic process|
|glycosphingolipid catabolic process|
|glycolipid catabolic process|
|glycosylceramide metabolic process|
|ceramide catabolic process|
|glycoside metabolic process|
|sphingolipid catabolic process|
|membrane lipid catabolic process|
|cellular carbohydrate catabolic process|
|glycosyl compound catabolic process|
|oligosaccharide metabolic process|
|glycosphingolipid metabolic process|
|ceramide metabolic process|
|glycolipid metabolic process|
|liposaccharide metabolic process|
|carbohydrate catabolic process|
|glycosyl compound metabolic process|
|sphingolipid metabolic process|
|cellular carbohydrate metabolic process|
|protein stabilization|
|carbohydrate derivative catabolic process|
|cellular lipid catabolic process|
|membrane lipid metabolic process|
|regulation of protein stability|
|lipid catabolic process|
|carbohydrate metabolic process|
|positive regulation of hydrolase activity|
|cellular amide metabolic process|
|cellular lipid metabolic process|
|carbohydrate derivative metabolic process|
|organonitrogen compound catabolic process|
|lipid metabolic process|
|regulation of hydrolase activity|
|positive regulation of catalytic activity|
|organic substance catabolic process|
|positive regulation of molecular function|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp289|Hydroxyurea 15μM R06 exp289]]|1.75|
|[[:results:exp295|Pyronaridine 1μM R06 exp295]]|1.99|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: N/A
^Tissue^Fraction Of Cell Lines Where Essential^
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16063
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -6.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GBA3 Expression in NALM6 Cells: -6.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>