GBP5 [The Human Chemical-Genetic Interaction Map Project]

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======= GBP5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GBP5
  * **<color #00a2e8>Official Name</color>**: guanylate binding protein 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=115362|115362]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96PP8|Q96PP8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GBP5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GBP5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611467|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene belongs to the TRAFAC class dynamin-like GTPase superfamily. The encoded protein acts as an activator of NLRP3 inflammasome assembly and has a role in innate immunity and inflammation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2017]. 
  * **<color #00a2e8>UniProt Summary</color>**:  As an activator of NLRP3 inflammasome assembly, plays a role in innate immunity and inflammation. Promotes selective NLRP3 inflammasome assembly in response to microbial and soluble, but not crystalline, agents (PubMed:22461501). Hydrolyzes GTP, but in contrast to other family members, does not produce GMP (PubMed:20180847). {ECO:0000269|PubMed:20180847, ECO:0000269|PubMed:22461501}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|GBP C|
|GBP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|interleukin-18 secretion|
|interleukin-18 production|
|positive regulation of NLRP3 inflammasome complex assembly|
|interleukin-1 beta secretion|
|interleukin-1 secretion|
|regulation of NLRP3 inflammasome complex assembly|
|interleukin-1 beta production|
|interleukin-1 production|
|positive regulation of cytokine production involved in inflammatory response|
|protein localization to Golgi apparatus|
|regulation of cytokine production involved in inflammatory response|
|cytokine secretion|
|protein homotetramerization|
|positive regulation of inflammatory response|
|protein tetramerization|
|cytokine production|
|protein secretion|
|establishment of protein localization to extracellular region|
|cellular response to interferon-gamma|
|protein localization to extracellular region|
|peptide secretion|
|response to interferon-gamma|
|positive regulation of protein complex assembly|
|cytoplasmic vesicle|
|GTPase activity|
|regulation of inflammatory response|
|protein homooligomerization|
|positive regulation of innate immune response|
|positive regulation of response to biotic stimulus|
|GTP binding|
|positive regulation of cytokine production|
|regulation of protein complex assembly|
|regulation of innate immune response|
|positive regulation of defense response|
|inflammatory response|
|positive regulation of multi-organism process|
|protein complex oligomerization|
|positive regulation of cellular component biogenesis|
|regulation of response to biotic stimulus|
|positive regulation of response to external stimulus|
|Golgi membrane|
|response to bacterium|
|regulation of cytokine production|
|perinuclear region of cytoplasm|
|protein localization to organelle|
|regulation of defense response|
|innate immune response|
|regulation of multi-organism process|
|positive regulation of immune response|
|protein homodimerization activity|
|defense response to other organism|
|regulation of cellular component biogenesis|
|Golgi apparatus|
|secretion by cell|
|cellular response to cytokine stimulus|
|export from cell|
|identical protein binding|
|regulation of response to external stimulus|
|response to cytokine|
|secretion|
|regulation of immune response|
|positive regulation of immune system process|
|positive regulation of cellular component organization|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|regulation of response to stress|
|protein transport|
|peptide transport|
|protein-containing complex assembly|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|regulation of immune system process|
|positive regulation of multicellular organismal process|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|immune response|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|1.72|
|[[:results:exp13|Chloramphenicol 20μM R00 exp13]]|1.74|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|1.79|
|[[:results:exp189|Temozolomide 200μM R04 exp189]]|2.04|
|[[:results:exp262|Alda-1 10μM R06 exp262]]|2.29|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12132
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.75 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GBP5 Expression in NALM6 Cells: 0.75'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>