GGCX [The Human Chemical-Genetic Interaction Map Project]

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======= GGCX =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GGCX
  * **<color #00a2e8>Official Name</color>**: gamma-glutamyl carboxylase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2677|2677]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P38435|P38435]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GGCX&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GGCX|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/137167|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes an integral membrane protein of the rough endoplasmic reticulum that carboxylates glutamate residues of vitamin K-dependent proteins to gamma carboxyl glutamate, a modification that is required for their activity. The vitamin K-dependent protein substrates have a propeptide that binds the enzyme, with carbon dioxide, dioxide, and reduced vitamin K acting as co-substrates. Vitamin K-dependent proteins affect a number of physiologic processes including blood coagulation, prevention of vascular calcification, and inflammation. Allelic variants of this gene have been associated with pseudoxanthoma elasticum-like disorder with associated multiple coagulation factor deficiency. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Mediates the vitamin K-dependent carboxylation of glutamate residues to calcium-binding gamma-carboxyglutamate (Gla) residues with the concomitant conversion of the reduced hydroquinone form of vitamin K to vitamin K epoxide. {ECO:0000269|PubMed:17073445}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|VKG Carbox|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|gamma-glutamyl carboxylase activity|
|peptidyl-glutamic acid carboxylation|
|protein carboxylation|
|peptidyl-glutamic acid modification|
|blood coagulation|
|coagulation|
|hemostasis|
|wound healing|
|regulation of body fluid levels|
|response to wounding|
|peptidyl-amino acid modification|
|endoplasmic reticulum membrane|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp53|Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53]]|-2.22|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|-1.92|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|1.71|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|1.77|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|1.82|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|2.13|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.497|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16216
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.64 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GGCX Expression in NALM6 Cells: 6.64'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>