GGTLC2 [The Human Chemical-Genetic Interaction Map Project]

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======= GGTLC2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GGTLC2
  * **<color #00a2e8>Official Name</color>**: gamma-glutamyltransferase light chain 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=91227|91227]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q14390|Q14390]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GGTLC2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GGTLC2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612339|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|G glu transpept|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|glutathione hydrolase activity|
|leukotriene D4 metabolic process|
|leukotriene D4 biosynthetic process|
|glutathione catabolic process|
|leukotriene biosynthetic process|
|cellular modified amino acid catabolic process|
|peptide catabolic process|
|leukotriene metabolic process|
|icosanoid biosynthetic process|
|sulfur compound catabolic process|
|glutathione metabolic process|
|cofactor catabolic process|
|fatty acid derivative biosynthetic process|
|icosanoid metabolic process|
|fatty acid derivative metabolic process|
|sulfur compound biosynthetic process|
|cellular modified amino acid metabolic process|
|carboxylic acid biosynthetic process|
|organic acid biosynthetic process|
|sulfur compound metabolic process|
|peptide biosynthetic process|
|cofactor metabolic process|
|drug metabolic process|
|amide biosynthetic process|
|peptide metabolic process|
|small molecule biosynthetic process|
|molecular function|
|cellular amide metabolic process|
|carboxylic acid metabolic process|
|oxoacid metabolic process|
|organic acid metabolic process|
|organonitrogen compound catabolic process|
|proteolysis|
|organonitrogen compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp219|A-395N 10μM R05 exp219]]|-2.13|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 633/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|24/28|
|blood|21/28|
|bone|23/26|
|breast|27/33|
|central nervous system|50/56|
|cervix|3/4|
|colorectal|15/17|
|esophagus|12/13|
|fibroblast|1/1|
|gastric|14/16|
|kidney|11/21|
|liver|16/20|
|lung|68/75|
|lymphocyte|13/16|
|ovary|24/26|
|pancreas|21/24|
|peripheral nervous system|15/16|
|plasma cell|11/15|
|prostate|1/1|
|skin|19/24|
|soft tissue|8/9|
|thyroid|2/2|
|upper aerodigestive|20/22|
|urinary tract|26/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3357
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -3.28 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GGTLC2 Expression in NALM6 Cells: -3.28'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>