GHRHR [The Human Chemical-Genetic Interaction Map Project]

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======= GHRHR =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GHRHR
  * **<color #00a2e8>Official Name</color>**: growth hormone releasing hormone receptor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2692|2692]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q02643|Q02643]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GHRHR&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GHRHR|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/139191|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a receptor for growth hormone-releasing hormone. Binding of this hormone to the receptor leads to synthesis and release of growth hormone. Mutations in this gene have been associated with isolated growth hormone deficiency (IGHD), also known as Dwarfism of Sindh, a disorder characterized by short stature. [provided by RefSeq, Jun 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Receptor for GRF, coupled to G proteins which activate adenylyl cyclase. Stimulates somatotroph cell growth, growth hormone gene transcription and growth hormone secretion.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|7tm 2|
|HRM|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|somatotropin secreting cell development|
|growth hormone-releasing hormone receptor activity|
|positive regulation of circadian sleep/wake cycle, non-REM sleep|
|somatotropin secreting cell differentiation|
|positive regulation of circadian sleep/wake cycle, sleep|
|regulation of circadian sleep/wake cycle, non-REM sleep|
|positive regulation of growth hormone secretion|
|adenohypophysis development|
|regulation of growth hormone secretion|
|positive regulation of insulin-like growth factor receptor signaling pathway|
|determination of adult lifespan|
|positive regulation of circadian rhythm|
|regulation of circadian sleep/wake cycle, sleep|
|regulation of circadian sleep/wake cycle|
|regulation of insulin-like growth factor receptor signaling pathway|
|nuclear outer membrane|
|positive regulation of behavior|
|positive regulation of multicellular organism growth|
|growth factor binding|
|multicellular organism aging|
|activation of adenylate cyclase activity|
|G protein-coupled peptide receptor activity|
|peptide hormone binding|
|pituitary gland development|
|lactation|
|nuclear inner membrane|
|regulation of multicellular organism growth|
|cellular response to glucose stimulus|
|cellular response to hexose stimulus|
|regulation of behavior|
|cellular response to monosaccharide stimulus|
|water homeostasis|
|body fluid secretion|
|diencephalon development|
|response to estrogen|
|regulation of intracellular steroid hormone receptor signaling pathway|
|cellular response to carbohydrate stimulus|
|secretory granule|
|cellular glucose homeostasis|
|positive regulation of peptide hormone secretion|
|sarcolemma|
|nuclear matrix|
|regulation of circadian rhythm|
|endocrine system development|
|mammary gland development|
|positive regulation of hormone secretion|
|adenylate cyclase-activating G protein-coupled receptor signaling pathway|
|response to glucose|
|response to hexose|
|response to glucocorticoid|
|cAMP-mediated signaling|
|response to monosaccharide|
|cell maturation|
|response to corticosteroid|
|cellular response to insulin stimulus|
|positive regulation of developmental growth|
|cyclic-nucleotide-mediated signaling|
|response to carbohydrate|
|glucose homeostasis|
|carbohydrate homeostasis|
|hormone metabolic process|
|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|
|regulation of peptide hormone secretion|
|response to insulin|
|developmental maturation|
|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|
|positive regulation of growth|
|cellular response to peptide hormone stimulus|
|regulation of hormone secretion|
|aging|
|positive regulation of peptide secretion|
|cellular response to peptide|
|response to steroid hormone|
|regulation of developmental growth|
|second-messenger-mediated signaling|
|forebrain development|
|response to peptide hormone|
|positive regulation of secretion by cell|
|gland development|
|positive regulation of secretion|
|response to peptide|
|regulation of peptide secretion|
|regulation of body fluid levels|
|regulation of hormone levels|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|cell surface|
|cellular response to nitrogen compound|
|regulation of growth|
|G protein-coupled receptor activity|
|regulation of peptide transport|
|brain development|
|cellular chemical homeostasis|
|regulation of secretion by cell|
|head development|
|regulation of secretion|
|multicellular organismal reproductive process|
|multicellular organism reproduction|
|response to lipid|
|cellular homeostasis|
|response to hormone|
|positive regulation of cell population proliferation|
|response to organic cyclic compound|
|central nervous system development|
|positive regulation of transport|
|response to organonitrogen compound|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|chemical homeostasis|
|secretion|
|cellular response to endogenous stimulus|
|G protein-coupled receptor signaling pathway|
|positive regulation of developmental process|
|reproductive process|
|reproduction|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|regulation of cell population proliferation|
|homeostatic process|
|cell development|
|positive regulation of signal transduction|
|intracellular signal transduction|
|positive regulation of multicellular organismal process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|1.85|
|[[:results:exp449|Arsenic trioxide 60μM R08 exp449]]|2.04|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|2.04|
|[[:results:exp111|R-DABN 8μM R03 exp111]]|2.07|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|2.74|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5173
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -6.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GHRHR Expression in NALM6 Cells: -6.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>