GID4 [The Human Chemical-Genetic Interaction Map Project]

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======= GID4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GID4
  * **<color #00a2e8>Official Name</color>**: GID complex subunit 4 homolog
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=79018|79018]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8IVV7|Q8IVV7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GID4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GID4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/617699|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Vac ImportDeg|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ubiquitin ligase complex|
|ubiquitin protein ligase activity|
|proteasome-mediated ubiquitin-dependent protein catabolic process|
|proteasomal protein catabolic process|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|modification-dependent macromolecule catabolic process|
|proteolysis involved in cellular protein catabolic process|
|cellular protein catabolic process|
|protein catabolic process|
|protein ubiquitination|
|protein modification by small protein conjugation|
|cellular macromolecule catabolic process|
|protein modification by small protein conjugation or removal|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|proteolysis|
|organic substance catabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp443|SNS-032 15μM R08 exp443]]|-1.87|
|[[:results:exp15|Cycloheximide 0.2μM R00 exp15]]|1.72|
|[[:results:exp389|PF-06409577 20μM R07 exp389]]|1.72|
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|1.74|
|[[:results:exp249|Vinorelbine 0.001μM R05 exp249]]|1.77|
|[[:results:exp247|UM0130462 0.025 to 0.035μM day4 R05 exp247]]|1.83|
|[[:results:exp334|All-trans-Retinoic-Acid 40μM R07 exp334]]|1.84|
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|1.84|
|[[:results:exp308|Rapamycin 2μM plus FK-506 5μM R07 exp308]]|1.87|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|2.05|
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|2.05|
|[[:results:exp421|VHL-ligand-1 20μM R07 exp421]]|2.28|
|[[:results:exp438|NN-Diethyl-meta-toluamide 500μM R08 exp438]]|2.34|
|[[:results:exp237|NN-Diethyl-meta-toluamide 100μM R05 exp237]]|2.38|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|2.99|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:chd4|CHD4]]|0.56|
|[[:human genes:p:prim1|PRIM1]]|0.538|
|[[:human genes:t:tfip11|TFIP11]]|0.522|
|[[:human genes:p:psmb4|PSMB4]]|0.496|
|[[:human genes:p:psma6|PSMA6]]|0.494|
|[[:human genes:c:copb1|COPB1]]|0.488|
|[[:human genes:d:dhx38|DHX38]]|0.488|
|[[:human genes:p:psmd11|PSMD11]]|0.485|
|[[:human genes:t:ticrr|TICRR]]|0.484|
|[[:human genes:s:supt5h|SUPT5H]]|0.47|
|[[:human genes:s:sf3a3|SF3A3]]|0.468|
|[[:human genes:e:exosc9|EXOSC9]]|0.462|
|[[:human genes:p:psmd3|PSMD3]]|0.459|
|[[:human genes:m:mt1e|MT1E]]|0.459|
|[[:human genes:a:aatf|AATF]]|0.456|
|[[:human genes:c:cbwd6|CBWD6]]|0.453|
|[[:human genes:t:tceb3c|TCEB3C]]|0.452|
|[[:human genes:a:ankle1|ANKLE1]]|0.451|
|[[:human genes:t:twistnb|TWISTNB]]|0.451|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.451|
|[[:human genes:c:cbwd3|CBWD3]]|0.45|
|[[:human genes:l:lrr1|LRR1]]|0.448|
|[[:human genes:c:copg1|COPG1]]|0.447|
|[[:human genes:t:tsg101|TSG101]]|0.445|
|[[:human genes:c:ccdc116|CCDC116]]|0.444|
|[[:human genes:g:gprin2|GPRIN2]]|0.444|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.442|
|[[:human genes:m:mtch2|MTCH2]]|0.442|
|[[:human genes:p:pan3|PAN3]]|0.441|
|[[:human genes:b:brd2|BRD2]]|0.44|
|[[:human genes:p:pole|POLE]]|0.439|
|[[:human genes:d:dtl|DTL]]|0.439|
|[[:human genes:m:med17|MED17]]|0.438|
|[[:human genes:p:pan2|PAN2]]|0.438|
|[[:human genes:o:orc1|ORC1]]|0.438|
|[[:human genes:p:plk4|PLK4]]|0.436|
|[[:human genes:a:atp6v1b2|ATP6V1B2]]|0.436|
|[[:human genes:u:ube2q2l|UBE2Q2L]]|0.436|
|[[:human genes:v:vasn|VASN]]|0.435|
|[[:human genes:a:akirin2|AKIRIN2]]|0.435|
|[[:human genes:r:rps19|RPS19]]|0.433|
|[[:human genes:m:med14|MED14]]|0.433|
|[[:human genes:c:ciapin1|CIAPIN1]]|0.43|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.43|
|[[:human genes:u:ubap1|UBAP1]]|0.43|
|[[:human genes:g:golga8o|GOLGA8O]]|0.428|
|[[:human genes:c:cactin|CACTIN]]|0.427|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.426|
|[[:human genes:n:nup153|NUP153]]|0.426|
|[[:human genes:a:aqr|AQR]]|0.426|
|[[:human genes:h:hist1h2be|HIST1H2BE]]|0.425|
|[[:human genes:s:slc4a1|SLC4A1]]|0.425|
|[[:human genes:n:nol8|NOL8]]|0.425|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.424|
|[[:human genes:n:nfatc4|NFATC4]]|0.424|
|[[:human genes:p:polr1a|POLR1A]]|0.424|
|[[:human genes:p:psma7|PSMA7]]|0.422|
|[[:human genes:c:ccna2|CCNA2]]|0.422|
|[[:human genes:r:rpl35|RPL35]]|0.421|
|[[:human genes:t:tgfbrap1|TGFBRAP1]]|0.42|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.419|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.419|
|[[:human genes:p:polr2f|POLR2F]]|0.419|
|[[:human genes:f:fam160a1|FAM160A1]]|0.419|
|[[:human genes:p:psmd7|PSMD7]]|0.418|
|[[:human genes:u:utp3|UTP3]]|0.418|
|[[:human genes:c:cbwd5|CBWD5]]|0.418|
|[[:human genes:t:tyms|TYMS]]|0.418|
|[[:human genes:t:taf1|TAF1]]|0.417|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.417|
|[[:human genes:k:krt78|KRT78]]|0.416|
|[[:human genes:n:npipb5|NPIPB5]]|0.416|
|[[:human genes:i:ik|IK]]|0.415|
|[[:human genes:d:dnttip2|DNTTIP2]]|0.414|
|[[:human genes:a:arcn1|ARCN1]]|0.412|
|[[:human genes:p:psmc5|PSMC5]]|0.412|
|[[:human genes:c:c14orf93|C14orf93]]|0.411|
|[[:human genes:o:orc6|ORC6]]|0.411|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.41|
|[[:human genes:p:plekha4|PLEKHA4]]|0.41|
|[[:human genes:d:ddtl|DDTL]]|0.41|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.41|
|[[:human genes:c:copa|COPA]]|0.41|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.409|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.409|
|[[:human genes:n:narfl|NARFL]]|0.409|
|[[:human genes:s:sh3bp1|SH3BP1]]|0.408|
|[[:human genes:o:osbp|OSBP]]|0.408|
|[[:human genes:k:kctd17|KCTD17]]|0.407|
|[[:human genes:c:col2a1|COL2A1]]|0.407|
|[[:human genes:m:mylk3|MYLK3]]|0.407|
|[[:human genes:c:cdc45|CDC45]]|0.406|
|[[:human genes:c:chaf1a|CHAF1A]]|0.406|
|[[:human genes:d:disp2|DISP2]]|0.406|
|[[:human genes:o:ogfr|OGFR]]|0.405|
|[[:human genes:p:psmc1|PSMC1]]|0.405|
|[[:human genes:a:atp6v0c|ATP6V0C]]|0.404|
|[[:human genes:n:napa|NAPA]]|0.404|
|[[:human genes:h:hnrnpc|HNRNPC]]|0.403|
|[[:human genes:z:znf830|ZNF830]]|0.403|
|[[:human genes:r:rps12|RPS12]]|0.402|
|[[:human genes:h:hap1|HAP1]]|0.401|
|[[:human genes:s:snrpa1|SNRPA1]]|0.4|
|[[:human genes:s:skiv2l2|SKIV2L2]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2257
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.09 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GID4 Expression in NALM6 Cells: 4.09'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>