GID8 [The Human Chemical-Genetic Interaction Map Project]

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======= GID8 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GID8
  * **<color #00a2e8>Official Name</color>**: GID complex subunit 8 homolog
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=54994|54994]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NWU2|Q9NWU2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GID8&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GID8|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611625|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|LisH|
|RanBPM CRA|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ubiquitin ligase complex|
|positive regulation of canonical Wnt signaling pathway|
|positive regulation of Wnt signaling pathway|
|regulation of canonical Wnt signaling pathway|
|cell-cell signaling by wnt|
|Wnt signaling pathway|
|regulation of Wnt signaling pathway|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|cell junction|
|protein homodimerization activity|
|positive regulation of cell population proliferation|
|cell-cell signaling|
|regulation of cell population proliferation|
|positive regulation of signal transduction|
|positive regulation of cell communication|
|positive regulation of signaling|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|-2.76|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|-2.63|
|[[:results:exp359|FK-506 30μM R07 exp359]]|-2.56|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|-2.5|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|-2.37|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-2.32|
|[[:results:exp312|2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312]]|-2.25|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|-2.25|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|-2.22|
|[[:results:exp382|Palbociclib 1μM R07 exp382]]|-2.18|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|-2.16|
|[[:results:exp330|5-Azacytidine 2μM R07 exp330]]|-2.14|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|-2.12|
|[[:results:exp90|WYE-354 6μM R02 exp90]]|-1.97|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|-1.83|
|[[:results:exp147|Resveratrol 16μM R03 exp147]]|-1.82|
|[[:results:exp183|IU1-C 25μM R04 exp183]]|-1.8|
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|-1.77|
|[[:results:exp310|2-Methoxyestradiol 0.55μM R07 exp310]]|-1.76|
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|-1.7|
|[[:results:exp240|Pyridostatin 4μM R05 exp240]]|1.71|
|[[:results:exp470|Chloroquine 32μM R08 exp470]]|1.82|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|2.03|
|[[:results:exp483|FTY720 3μM R08 exp483]]|2.08|
|[[:results:exp229|Dimethyloxaloylglycine 100μM R05 exp229]]|2.13|
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|2.32|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|2.61|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|2.62|
|[[:results:exp306|Rapamycin 2μM R07 exp306]]|2.88|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|3.15|
|[[:results:exp116|AICAR 240μM R03 exp116]]|3.24|
|[[:results:exp429|Rapamycin 0.001μM R08 exp429]]|3.66|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|4.19|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:maea|MAEA]]|0.809|
|[[:human genes:w:wdr26|WDR26]]|0.751|
|[[:human genes:u:ube2h|UBE2H]]|0.733|
|[[:human genes:r:rmnd5a|RMND5A]]|0.654|
|[[:human genes:y:ypel5|YPEL5]]|0.645|
|[[:human genes:c:cnot8|CNOT8]]|0.479|
|[[:human genes:m:memo1|MEMO1]]|0.435|
|[[:human genes:r:ranbp9|RANBP9]]|0.42|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8159
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.82 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GID8 Expression in NALM6 Cells: 6.82'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>