GIGYF2 [The Human Chemical-Genetic Interaction Map Project]

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======= GIGYF2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GIGYF2
  * **<color #00a2e8>Official Name</color>**: GRB10 interacting GYF protein 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=26058|26058]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q6Y7W6|Q6Y7W6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GIGYF2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GIGYF2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612003|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene contains CAG trinucleotide repeats and encodes a protein containing several stretches of polyglutamine residues. The encoded protein may be involved in the regulation of tyrosine kinase receptor signaling. This gene is located in a chromosomal region that was genetically linked to Parkinson disease type 11, and mutations in this gene were thought to be causative for this disease. However, more recent studies in different populations have been unable to replicate this association. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Key component of the 4EHP-GYF2 complex, a multiprotein complex that acts as a repressor of translation initiation (PubMed:22751931). In 4EHP-GYF2 the complex, acts as a factor that bridges EIF4E2 to ZFP36/TTP, linking translation repression with mRNA decay (By similarity). May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling, including IGF1 and insulin receptors (PubMed:12771153). {ECO:0000250|UniProtKB:Q6Y7W8, ECO:0000269|PubMed:12771153, ECO:0000269|PubMed:22751931}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|GYF|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|proximal dendrite|
|insulin-like growth factor receptor signaling pathway|
|proline-rich region binding|
|homeostasis of number of cells within a tissue|
|mRNA destabilization|
|RNA destabilization|
|spinal cord motor neuron differentiation|
|musculoskeletal movement|
|multicellular organismal movement|
|ventral spinal cord development|
|positive regulation of mRNA catabolic process|
|neuromuscular process controlling balance|
|cell differentiation in spinal cord|
|posttranscriptional gene silencing|
|mitotic G1/S transition checkpoint|
|mitotic G1 DNA damage checkpoint|
|G1 DNA damage checkpoint|
|cytoplasmic stress granule|
|adult locomotory behavior|
|positive regulation of mRNA metabolic process|
|multicellular organism growth|
|feeding behavior|
|post-embryonic development|
|mitotic DNA damage checkpoint|
|negative regulation of G1/S transition of mitotic cell cycle|
|mitotic DNA integrity checkpoint|
|negative regulation of cell cycle G1/S phase transition|
|spinal cord development|
|neuromuscular process|
|negative regulation of translation|
|DNA damage checkpoint|
|perikaryon|
|DNA integrity checkpoint|
|adult behavior|
|negative regulation of cellular amide metabolic process|
|regulation of G1/S transition of mitotic cell cycle|
|gene silencing|
|mitotic cell cycle checkpoint|
|regulation of cell cycle G1/S phase transition|
|central nervous system neuron differentiation|
|regulation of mRNA stability|
|regulation of RNA stability|
|tissue homeostasis|
|cell cycle checkpoint|
|locomotory behavior|
|homeostasis of number of cells|
|regulation of mRNA catabolic process|
|negative regulation of mitotic cell cycle phase transition|
|negative regulation of cell cycle phase transition|
|regulation of gene expression, epigenetic|
|endosome|
|negative regulation of mitotic cell cycle|
|cadherin binding|
|multicellular organismal homeostasis|
|negative regulation of cell cycle process|
|regulation of mRNA metabolic process|
|anatomical structure homeostasis|
|regulation of translation|
|positive regulation of cellular catabolic process|
|developmental growth|
|growth|
|regulation of cellular amide metabolic process|
|regulation of mitotic cell cycle phase transition|
|positive regulation of catabolic process|
|regulation of cell cycle phase transition|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|posttranscriptional regulation of gene expression|
|behavior|
|negative regulation of cell cycle|
|protein-containing complex|
|mitotic cell cycle process|
|regulation of mitotic cell cycle|
|mitotic cell cycle|
|enzyme linked receptor protein signaling pathway|
|regulation of cell cycle process|
|cellular response to DNA damage stimulus|
|regulation of cellular catabolic process|
|central nervous system development|
|Golgi apparatus|
|regulation of catabolic process|
|cell cycle process|
|endoplasmic reticulum|
|neuron differentiation|
|negative regulation of cellular protein metabolic process|
|negative regulation of protein metabolic process|
|regulation of cell cycle|
|cell cycle|
|nervous system process|
|negative regulation of cellular macromolecule biosynthetic process|
|RNA binding|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|generation of neurons|
|negative regulation of biosynthetic process|
|neurogenesis|
|homeostatic process|
|cellular response to stress|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of nucleobase-containing compound metabolic process|
|system process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp134|MS023 2μM R03 exp134]]|-2.77|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|-2.66|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|-2.52|
|[[:results:exp261|ABT-702 5μM R06 exp261]]|-2.11|
|[[:results:exp380|NMS-873 0.07μM R07 exp380]]|-2.1|
|[[:results:exp275|Citral 75μM R06 exp275]]|-1.96|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|-1.95|
|[[:results:exp189|Temozolomide 200μM R04 exp189]]|-1.87|
|[[:results:exp220|BAY-598 4μM R05 exp220]]|-1.86|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|-1.85|
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|-1.79|
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|-1.78|
|[[:results:exp536|Vitamin-D3 40μM R08 exp536]]|-1.73|
|[[:results:exp225|Celastrol 0.12μM R05 exp225]]|1.73|
|[[:results:exp539|42°C R08 exp539]]|1.74|
|[[:results:exp70|INK128 0.2μM R02 exp70]]|1.79|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1886
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.76 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GIGYF2 Expression in NALM6 Cells: 6.76'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>