GIPC1 [The Human Chemical-Genetic Interaction Map Project]

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======= GIPC1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GIPC1
  * **<color #00a2e8>Official Name</color>**: GIPC PDZ domain containing family member 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10755|10755]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O14908|O14908]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GIPC1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GIPC1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605072|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May be involved in G protein-linked signaling.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PDZ|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of melanin biosynthetic process|
|positive regulation of secondary metabolite biosynthetic process|
|regulation of melanin biosynthetic process|
|regulation of secondary metabolite biosynthetic process|
|regulation of secondary metabolic process|
|myosin binding|
|positive regulation of cellular response to transforming growth factor beta stimulus|
|vesicle membrane|
|cellular response to interleukin-7|
|glutamate secretion|
|positive regulation of transforming growth factor beta receptor signaling pathway|
|response to interleukin-7|
|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|
|dendritic shaft|
|positive regulation of cytokinesis|
|acidic amino acid transport|
|negative regulation of ubiquitin-dependent protein catabolic process|
|brush border|
|negative regulation of proteasomal protein catabolic process|
|endocytic vesicle|
|endothelial cell migration|
|negative regulation of proteolysis involved in cellular protein catabolic process|
|regulation of synaptic vesicle exocytosis|
|dicarboxylic acid transport|
|acid secretion|
|Schaffer collateral - CA1 synapse|
|epithelial cell migration|
|positive regulation of cell division|
|epithelium migration|
|negative regulation of cellular protein catabolic process|
|PDZ domain binding|
|regulation of cytokinesis|
|tissue migration|
|positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|regulation of neurotransmitter secretion|
|regulation of synaptic vesicle cycle|
|regulation of transforming growth factor beta receptor signaling pathway|
|regulation of cellular response to transforming growth factor beta stimulus|
|amino acid transport|
|synaptic vesicle|
|regulation of proteasomal ubiquitin-dependent protein catabolic process|
|negative regulation of protein catabolic process|
|cell cortex|
|regulation of neurotransmitter transport|
|dendritic spine|
|regulation of ubiquitin-dependent protein catabolic process|
|regulation of regulated secretory pathway|
|regulation of cell division|
|ameboidal-type cell migration|
|regulation of proteasomal protein catabolic process|
|regulation of synaptic plasticity|
|regulation of proteolysis involved in cellular protein catabolic process|
|regulation of exocytosis|
|regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|regulation of cellular protein catabolic process|
|cytoplasmic vesicle|
|negative regulation of cellular catabolic process|
|actin binding|
|regulation of cellular response to growth factor stimulus|
|positive regulation of cell cycle process|
|regulation of protein stability|
|organic acid transport|
|carboxylic acid transport|
|cadherin binding|
|negative regulation of catabolic process|
|signaling receptor binding|
|glutamatergic synapse|
|negative regulation of proteolysis|
|regulation of neurotransmitter levels|
|protein targeting|
|positive regulation of cell cycle|
|regulation of protein catabolic process|
|chemical synaptic transmission|
|anterograde trans-synaptic signaling|
|trans-synaptic signaling|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|organic anion transport|
|synaptic signaling|
|regulation of vesicle-mediated transport|
|anion transport|
|regulation of proteolysis|
|regulation of secretion by cell|
|regulation of cell cycle process|
|regulation of secretion|
|regulation of cellular catabolic process|
|protein homodimerization activity|
|regulation of cellular localization|
|cell migration|
|intracellular protein transport|
|regulation of catabolic process|
|secretion by cell|
|cellular response to cytokine stimulus|
|negative regulation of cellular protein metabolic process|
|export from cell|
|cell motility|
|localization of cell|
|response to cytokine|
|negative regulation of protein metabolic process|
|cell-cell signaling|
|secretion|
|regulation of cell cycle|
|locomotion|
|G protein-coupled receptor signaling pathway|
|ion transport|
|protein transport|
|intracellular transport|
|peptide transport|
|movement of cell or subcellular component|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|positive regulation of signal transduction|
|positive regulation of cell communication|
|positive regulation of signaling|
|establishment of localization in cell|
|nitrogen compound transport|
|regulation of transport|
|positive regulation of cellular biosynthetic process|
|membrane|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp189|Temozolomide 200μM R04 exp189]]|1.73|
|[[:results:exp476|Dihydrosphingosine 8μM R08 exp476]]|1.8|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2824
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.21 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GIPC1 Expression in NALM6 Cells: 4.21'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>