GJC3 [The Human Chemical-Genetic Interaction Map Project]

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======= GJC3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GJC3
  * **<color #00a2e8>Official Name</color>**: gap junction protein gamma 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=349149|349149]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8NFK1|Q8NFK1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GJC3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GJC3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611925|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a gap junction protein. The encoded protein, also known as a connexin, plays a role in formation of gap junctions, which provide direct connections between neighboring cells. Mutations in this gene have been reported to be associated with nonsyndromic hearing loss.[provided by RefSeq, Feb 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Connexin|
|Connexin CCC|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|AV node cell to bundle of His cell communication by electrical coupling|
|gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling|
|AV node cell to bundle of His cell communication|
|cell communication by electrical coupling involved in cardiac conduction|
|cell communication by electrical coupling|
|connexin complex|
|myelin sheath|
|cell communication involved in cardiac conduction|
|cardiac conduction|
|myelination|
|ensheathment of neurons|
|axon ensheathment|
|multicellular organismal signaling|
|sensory perception of sound|
|sensory perception of mechanical stimulus|
|regulation of heart contraction|
|regulation of blood circulation|
|regulation of system process|
|protein homodimerization activity|
|sensory perception|
|nervous system process|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|1.7|
|[[:results:exp352|Dexamethasone 0.006 to 0.015μM on day4 R07 exp352]]|1.74|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:polr2j3|POLR2J3]]|0.528|
|[[:human genes:p:prpf8|PRPF8]]|0.419|
|[[:human genes:n:npipb8|NPIPB8]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2274
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.64 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GJC3 Expression in NALM6 Cells: -2.64'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>