GLP1R [The Human Chemical-Genetic Interaction Map Project]

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======= GLP1R =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GLP1R
  * **<color #00a2e8>Official Name</color>**: glucagon like peptide 1 receptor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2740|2740]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P43220|P43220]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GLP1R&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GLP1R|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/138032|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  G-protein coupled receptor for glucagon-like peptide 1 (GLP-1) (PubMed:8405712, PubMed:8216285, PubMed:7517895, PubMed:19861722, PubMed:26308095, PubMed:27196125, PubMed:28514449). Ligand binding triggers activation of a signaling cascade that leads to the activation of adenylyl cyclase and increased intracellular cAMP levels (PubMed:8405712, PubMed:8216285, PubMed:7517895, PubMed:19861722, PubMed:26308095, PubMed:27196125, PubMed:28514449). Plays a role in regulating insulin secretion in response to GLP-1 (By similarity). {ECO:0000250|UniProtKB:O35659, ECO:0000269|PubMed:19861722, ECO:0000269|PubMed:26308095, ECO:0000269|PubMed:27196125, ECO:0000269|PubMed:28514449, ECO:0000269|PubMed:7517895, ECO:0000269|PubMed:8216285, ECO:0000269|PubMed:8405712}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|7tm 2|
|HRM|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|glucagon-like peptide 1 receptor activity|
|glucagon receptor activity|
|response to psychosocial stress|
|cellular response to glucagon stimulus|
|response to glucagon|
|positive regulation of blood pressure|
|activation of adenylate cyclase activity|
|G protein-coupled peptide receptor activity|
|peptide hormone binding|
|adenylate cyclase-activating G protein-coupled receptor signaling pathway|
|transmembrane signaling receptor activity|
|cAMP-mediated signaling|
|cyclic-nucleotide-mediated signaling|
|regulation of insulin secretion|
|regulation of blood pressure|
|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|
|regulation of peptide hormone secretion|
|regulation of heart contraction|
|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|
|learning or memory|
|cellular response to peptide hormone stimulus|
|regulation of hormone secretion|
|positive regulation of cytosolic calcium ion concentration|
|regulation of blood circulation|
|cognition|
|cellular response to peptide|
|regulation of cytosolic calcium ion concentration|
|second-messenger-mediated signaling|
|blood circulation|
|response to peptide hormone|
|circulatory system process|
|cellular calcium ion homeostasis|
|calcium ion homeostasis|
|regulation of protein secretion|
|cellular divalent inorganic cation homeostasis|
|response to peptide|
|divalent inorganic cation homeostasis|
|regulation of peptide secretion|
|regulation of hormone levels|
|cellular metal ion homeostasis|
|behavior|
|regulation of system process|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|metal ion homeostasis|
|cellular cation homeostasis|
|cellular ion homeostasis|
|cellular response to nitrogen compound|
|cation homeostasis|
|regulation of protein transport|
|inorganic ion homeostasis|
|regulation of peptide transport|
|cellular chemical homeostasis|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|ion homeostasis|
|regulation of secretion|
|cellular homeostasis|
|response to hormone|
|response to organonitrogen compound|
|regulation of protein localization|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|chemical homeostasis|
|cellular response to endogenous stimulus|
|G protein-coupled receptor signaling pathway|
|nervous system process|
|integral component of plasma membrane|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|homeostatic process|
|intracellular signal transduction|
|regulation of transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp418|Tunicamycin 0.04μM R07 exp418]]|-1.88|
|[[:results:exp143|Phenformin 20μM R03 exp143]]|-1.87|
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|-1.72|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7668
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.21 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GLP1R Expression in NALM6 Cells: -2.21'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>