GLRA2 [The Human Chemical-Genetic Interaction Map Project]

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======= GLRA2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GLRA2
  * **<color #00a2e8>Official Name</color>**: glycine receptor alpha 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2742|2742]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P23416|P23416]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GLRA2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GLRA2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/305990|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The glycine receptor consists of two subunits, alpha and beta, and acts as a pentamer. The protein encoded by this gene is an alpha subunit and can bind strychnine. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine (PubMed:2155780, PubMed:15302677, PubMed:16144831, PubMed:23895467, PubMed:25445488). Channel opening is also triggered by taurine and beta-alanine (PubMed:15302677). Plays a role in the down-regulation of neuronal excitability. Contributes to the generation of inhibitory postsynaptic currents (PubMed:25445488). Plays a role in cellular responses to ethanol (PubMed:23895467). {ECO:0000269|PubMed:15302677, ECO:0000269|PubMed:16144831, ECO:0000269|PubMed:2155780, ECO:0000269|PubMed:23895467, ECO:0000269|PubMed:25445488}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Neur chan memb|
|Neur chan LBD|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|glycine-gated chloride ion channel activity|
|extracellularly glycine-gated chloride channel activity|
|glycinergic synapse|
|synaptic transmission, glycinergic|
|cellular response to ethanol|
|glycine binding|
|cellular response to zinc ion|
|transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential|
|chloride channel complex|
|extracellular ligand-gated ion channel activity|
|response to zinc ion|
|chloride channel activity|
|excitatory postsynaptic potential|
|chemical synaptic transmission, postsynaptic|
|cellular response to amino acid stimulus|
|cellular response to alcohol|
|chloride transmembrane transport|
|regulation of postsynaptic membrane potential|
|chloride transport|
|neuropeptide signaling pathway|
|inorganic anion transmembrane transport|
|response to amino acid|
|cellular response to antibiotic|
|response to ethanol|
|transmembrane signaling receptor activity|
|inorganic anion transport|
|cellular response to metal ion|
|postsynaptic membrane|
|cellular response to acid chemical|
|cellular response to toxic substance|
|cellular response to inorganic substance|
|response to alcohol|
|synapse|
|anion transmembrane transport|
|response to antibiotic|
|neuron projection|
|response to acid chemical|
|response to metal ion|
|cellular response to drug|
|chemical synaptic transmission|
|anterograde trans-synaptic signaling|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|regulation of membrane potential|
|trans-synaptic signaling|
|synaptic signaling|
|response to toxic substance|
|response to inorganic substance|
|cell junction|
|anion transport|
|cellular response to organonitrogen compound|
|inorganic ion transmembrane transport|
|cellular response to nitrogen compound|
|ion transmembrane transport|
|response to organonitrogen compound|
|response to drug|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|cell-cell signaling|
|cellular response to endogenous stimulus|
|transmembrane transport|
|G protein-coupled receptor signaling pathway|
|ion transport|
|nervous system process|
|integral component of plasma membrane|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp85|UM0129480 7μM R02 exp85]]|1.91|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/26|
|bone|0/26|
|breast|0/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|0/72|
|lymphocyte|0/16|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12961
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.61 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GLRA2 Expression in NALM6 Cells: 0.61'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>