GNAI1 [The Human Chemical-Genetic Interaction Map Project]

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======= GNAI1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GNAI1
  * **<color #00a2e8>Official Name</color>**: G protein subunit alpha i1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2770|2770]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P63096|P63096]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GNAI1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GNAI1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/139310|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|G-alpha|
|Arf|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|G protein-coupled serotonin receptor binding|
|positive regulation of protein localization to cell cortex|
|regulation of protein localization to cell cortex|
|cellular response to forskolin|
|response to forskolin|
|response to platelet aggregation inhibitor|
|cell cortex region|
|GTPase activating protein binding|
|G-protein beta/gamma-subunit complex binding|
|heterotrimeric G-protein complex|
|regulation of mitotic spindle organization|
|regulation of spindle organization|
|regulation of cAMP-mediated signaling|
|negative regulation of synaptic transmission|
|positive regulation of protein localization to cell periphery|
|G protein-coupled receptor binding|
|GDP binding|
|cellular response to alcohol|
|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway|
|cellular response to ketone|
|regulation of protein localization to cell periphery|
|cellular response to antibiotic|
|midbody|
|regulation of microtubule cytoskeleton organization|
|response to ketone|
|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|
|magnesium ion binding|
|regulation of microtubule-based process|
|membrane raft|
|protein folding|
|response to alcohol|
|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|
|lysosomal membrane|
|response to antibiotic|
|positive regulation of cellular protein localization|
|GTPase activity|
|GTP binding|
|response to peptide hormone|
|cellular response to drug|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|response to peptide|
|centrosome|
|cell division|
|cellular response to lipid|
|regulation of cellular protein localization|
|regulation of cytoskeleton organization|
|cellular response to organic cyclic compound|
|regulation of mitotic cell cycle|
|regulation of cell cycle process|
|response to lipid|
|nucleolus|
|response to hormone|
|regulation of cellular localization|
|response to organic cyclic compound|
|response to organonitrogen compound|
|response to drug|
|regulation of protein localization|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|regulation of cell cycle|
|regulation of organelle organization|
|G protein-coupled receptor signaling pathway|
|cell cycle|
|negative regulation of cell communication|
|negative regulation of signaling|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|regulation of intracellular signal transduction|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|1.73|
|[[:results:exp120|Dimethyl-Sulfoxide 1pc R03 exp120]]|2.02|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17216
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.28 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GNAI1 Expression in NALM6 Cells: 3.28'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>