GNB5 [The Human Chemical-Genetic Interaction Map Project]

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======= GNB5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GNB5
  * **<color #00a2e8>Official Name</color>**: G protein subunit beta 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10681|10681]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O14775|O14775]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GNB5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GNB5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604447|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. Alternatively spliced transcript variants encoding different isoforms exist. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Enhances GTPase-activating protein (GAP) activity of regulator of G protein signaling (RGS) proteins, hence involved in the termination of the signaling initiated by the G protein coupled receptors (GPCRs) by accelerating the GTP hydrolysis on the G-alpha subunits, thereby promoting their inactivation (Probable). Increases RGS9 GTPase-activating protein (GAP) activity, hence contributes to the deactivation of G protein signaling initiated by D(2) dopamine receptors (PubMed:27677260). May play an important role in neuronal signaling, including in the parasympathetic, but not sympathetic, control of heart rate (By similarity). {ECO:0000250|UniProtKB:A1L271, ECO:0000269|PubMed:27677260, ECO:0000305}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|WD40|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|GTPase activator complex|
|G-protein gamma-subunit binding|
|negative regulation of voltage-gated calcium channel activity|
|negative regulation of calcium ion transmembrane transporter activity|
|dopamine receptor signaling pathway|
|regulation of voltage-gated calcium channel activity|
|negative regulation of calcium ion transmembrane transport|
|negative regulation of cation channel activity|
|negative regulation of calcium ion transport|
|negative regulation of ion transmembrane transporter activity|
|negative regulation of transporter activity|
|negative regulation of cation transmembrane transport|
|cellular response to dopamine|
|response to dopamine|
|regulation of calcium ion transmembrane transporter activity|
|signal transduction involved in cellular response to ammonium ion|
|presynapse|
|negative regulation of ion transmembrane transport|
|cellular response to monoamine stimulus|
|cellular response to catecholamine stimulus|
|chaperone binding|
|response to catecholamine|
|response to monoamine|
|negative regulation of transmembrane transport|
|cellular response to ammonium ion|
|negative regulation of ion transport|
|regulation of calcium ion transmembrane transport|
|regulation of cation channel activity|
|response to ammonium ion|
|protein folding|
|regulation of calcium ion transport|
|regulation of ion transmembrane transporter activity|
|regulation of transmembrane transporter activity|
|regulation of transporter activity|
|GTPase activator activity|
|GTPase activity|
|regulation of cation transmembrane transport|
|regulation of metal ion transport|
|cellular response to drug|
|positive regulation of GTPase activity|
|regulation of ion transmembrane transport|
|regulation of GTPase activity|
|negative regulation of transport|
|cellular response to organic cyclic compound|
|regulation of transmembrane transport|
|cellular response to organonitrogen compound|
|cellular response to nitrogen compound|
|regulation of ion transport|
|positive regulation of hydrolase activity|
|response to organic cyclic compound|
|response to organonitrogen compound|
|response to drug|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|negative regulation of molecular function|
|cellular response to endogenous stimulus|
|regulation of hydrolase activity|
|positive regulation of catalytic activity|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|positive regulation of molecular function|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|-2|
|[[:results:exp49|NFN1 0.1μM R01 exp49]]|1.94|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6195
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.26 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GNB5 Expression in NALM6 Cells: 5.26'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>