GNL2 [The Human Chemical-Genetic Interaction Map Project]

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======= GNL2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GNL2
  * **<color #00a2e8>Official Name</color>**: G protein nucleolar 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=29889|29889]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q13823|Q13823]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GNL2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GNL2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609365|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation (By similarity). May promote cell proliferation possibly by increasing p53/TP53 protein levels, and consequently those of its downstream product CDKN1A/p21, and decreasing RPL23A protein levels (PubMed:26203195). {ECO:0000250, ECO:0000269|PubMed:26203195}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|MMR HSR1|
|NGP1NT|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ribosome biogenesis|
|GTPase activity|
|GTP binding|
|ribonucleoprotein complex biogenesis|
|nucleolus|
|RNA binding|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|-2.84|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|-2.07|
|[[:results:exp124|GSK343 3μM R03 exp124]]|1.7|
|[[:results:exp476|Dihydrosphingosine 8μM R08 exp476]]|1.74|
|[[:results:exp131|L-74142 5μM R03 exp131]]|1.99|
|[[:results:exp486|Heregulin-B 44ng/ml R08 exp486]]|2.23|
|[[:results:exp50|Nicotinamide 2000μM R01 exp50]]|2.24|
|[[:results:exp53|Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53]]|2.64|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:u:utp3|UTP3]]|0.418|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.403|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 514/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|18/28|
|blood|20/28|
|bone|16/26|
|breast|23/33|
|central nervous system|41/56|
|cervix|4/4|
|colorectal|13/17|
|esophagus|8/13|
|fibroblast|0/1|
|gastric|9/16|
|kidney|19/21|
|liver|15/20|
|lung|52/75|
|lymphocyte|12/16|
|ovary|13/26|
|pancreas|18/24|
|peripheral nervous system|13/16|
|plasma cell|7/15|
|prostate|1/1|
|skin|19/24|
|soft tissue|8/9|
|thyroid|1/2|
|upper aerodigestive|14/22|
|urinary tract|19/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1703
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.1 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GNL2 Expression in NALM6 Cells: 7.1'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>