GNRH1 [The Human Chemical-Genetic Interaction Map Project]

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======= GNRH1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GNRH1
  * **<color #00a2e8>Official Name</color>**: gonadotropin releasing hormone 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2796|2796]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P01148|P01148]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GNRH1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GNRH1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/152760|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a preproprotein that is proteolytically processed to generate a peptide that is a member of the gonadotropin-releasing hormone (GnRH) family of peptides. Alternative splicing results in multiple transcript variants, at least one of which is secreted and then cleaved to generate gonadoliberin-1 and GnRH-associated peptide 1. Gonadoliberin-1 stimulates the release of luteinizing and follicle stimulating hormones, which are important for reproduction. Mutations in this gene are associated with hypogonadotropic hypogonadism. [provided by RefSeq, Nov 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|neurosecretory vesicle|
|gonadotropin-releasing hormone receptor binding|
|gonadotropin hormone-releasing hormone activity|
|response to prolactin|
|negative regulation of immature T cell proliferation|
|cytoplasmic side of rough endoplasmic reticulum membrane|
|regulation of ovarian follicle development|
|regulation of immature T cell proliferation|
|negative regulation of neuron migration|
|regulation of female gonad development|
|male sex determination|
|response to potassium ion|
|estrous cycle|
|Golgi-associated vesicle|
|regulation of gonad development|
|response to prostaglandin E|
|sex determination|
|response to prostaglandin|
|response to testosterone|
|regulation of neuron migration|
|axon terminus|
|negative regulation of T cell proliferation|
|ovulation cycle|
|negative regulation of mononuclear cell proliferation|
|negative regulation of lymphocyte proliferation|
|negative regulation of leukocyte proliferation|
|response to fatty acid|
|hormone activity|
|negative regulation of T cell activation|
|negative regulation of leukocyte cell-cell adhesion|
|response to ethanol|
|perikaryon|
|negative regulation of lymphocyte activation|
|regulation of T cell proliferation|
|regulation of reproductive process|
|response to corticosteroid|
|negative regulation of cell-cell adhesion|
|negative regulation of leukocyte activation|
|female pregnancy|
|response to ketone|
|negative regulation of cell activation|
|regulation of lymphocyte proliferation|
|regulation of mononuclear cell proliferation|
|multi-multicellular organism process|
|regulation of leukocyte proliferation|
|response to alcohol|
|negative regulation of cell migration|
|negative regulation of cell adhesion|
|negative regulation of cell motility|
|rhythmic process|
|aging|
|negative regulation of neurogenesis|
|regulation of leukocyte cell-cell adhesion|
|response to antibiotic|
|negative regulation of cellular component movement|
|negative regulation of nervous system development|
|response to lipopolysaccharide|
|regulation of T cell activation|
|negative regulation of locomotion|
|response to molecule of bacterial origin|
|response to steroid hormone|
|negative regulation of cell development|
|response to acid chemical|
|response to metal ion|
|response to peptide hormone|
|regulation of cell-cell adhesion|
|dendrite|
|negative regulation of immune system process|
|response to peptide|
|response to toxic substance|
|regulation of lymphocyte activation|
|response to inorganic substance|
|regulation of leukocyte activation|
|regulation of cell activation|
|developmental process involved in reproduction|
|negative regulation of cell population proliferation|
|regulation of cell adhesion|
|response to bacterium|
|negative regulation of cell differentiation|
|regulation of neurogenesis|
|multicellular organismal reproductive process|
|multicellular organism reproduction|
|regulation of cell migration|
|response to lipid|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|response to hormone|
|regulation of cell motility|
|response to organic cyclic compound|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|regulation of locomotion|
|negative regulation of cell death|
|multi-organism reproductive process|
|regulation of cellular component movement|
|response to organonitrogen compound|
|response to drug|
|response to nitrogen compound|
|cell-cell signaling|
|negative regulation of multicellular organismal process|
|mitochondrion|
|response to other organism|
|response to external biotic stimulus|
|G protein-coupled receptor signaling pathway|
|response to biotic stimulus|
|reproductive process|
|reproduction|
|response to endogenous stimulus|
|generation of neurons|
|regulation of apoptotic process|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|extracellular space|
|regulation of cell population proliferation|
|neurogenesis|
|regulation of immune system process|
|regulation of cell death|
|regulation of cell differentiation|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp356|Docosahexaenoic-acid 50μM R07 exp356]]|-1.71|
|[[:results:exp292|Menadione 5μM R06 exp292]]|2|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9138
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.83 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GNRH1 Expression in NALM6 Cells: 1.83'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>