GOLGA2 [The Human Chemical-Genetic Interaction Map Project]

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======= GOLGA2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GOLGA2
  * **<color #00a2e8>Official Name</color>**: golgin A2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2801|2801]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q08379|Q08379]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GOLGA2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GOLGA2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602580|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Peripheral membrane component of the cis-Golgi stack that acts as a membrane skeleton that maintains the structure of the Golgi apparatus, and as a vesicle thether that facilitates vesicle fusion to the Golgi membrane. Together with p115/USO1 and STX5, involved in vesicle tethering and fusion at the cis-Golgi membrane to maintain the stacked and inter-connected structure of the Golgi apparatus. Plays a central role in mitotic Golgi disassembly: phosphorylation at Ser-37 by CDK1 at the onset of mitosis inhibits the interaction with p115/USO1, preventing tethering of COPI vesicles and thereby inhibiting transport through the Golgi apparatus during mitosis (By similarity). Also plays a key role in spindle pole assembly and centrosome organization (PubMed:26165940). Promotes the mitotic spindle pole assembly by activating the spindle assembly factor TPX2 to nucleate microtubules around the Golgi and capture them to couple mitotic membranes to the spindle: upon phosphorylation at the onset of mitosis, GOLGA2 interacts with importin-alpha via the nuclear localization signal region, leading to recruit importin- alpha to the Golgi membranes and liberate the spindle assembly factor TPX2 from importin-alpha. TPX2 then activates AURKA kinase and stimulates local microtubule nucleation. Upon filament assembly, nascent microtubules are further captured by GOLGA2, thus linking Golgi membranes to the spindle (PubMed:19242490, PubMed:26165940). Regulates the meiotic spindle pole assembly, probably via the same mechanism (By similarity). Also regulates the centrosome organization (PubMed:18045989, PubMed:19109421). Also required for the Golgi ribbon formation and glycosylation of membrane and secretory proteins (PubMed:16489344, PubMed:17314401). {ECO:0000250|UniProtKB:Q62839, ECO:0000250|UniProtKB:Q921M4, ECO:0000269|PubMed:16489344, ECO:0000269|PubMed:17314401, ECO:0000269|PubMed:18045989, ECO:0000269|PubMed:19109421, ECO:0000269|PubMed:19242490, ECO:0000269|PubMed:26165940}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|spindle assembly involved in meiosis|
|Golgi disassembly|
|importin-alpha family protein binding|
|positive regulation of protein glycosylation|
|organelle inheritance|
|Golgi inheritance|
|positive regulation of ubiquitin protein ligase activity|
|Golgi ribbon formation|
|meiotic spindle organization|
|regulation of protein glycosylation|
|asymmetric cell division|
|microtubule nucleation|
|positive regulation of glycoprotein biosynthetic process|
|positive regulation of glycoprotein metabolic process|
|regulation of ubiquitin protein ligase activity|
|Golgi cis cisterna|
|positive regulation of ubiquitin-protein transferase activity|
|microtubule polymerization|
|mitotic spindle assembly|
|regulation of glycoprotein biosynthetic process|
|COPII-coated ER to Golgi transport vesicle|
|regulation of glycoprotein metabolic process|
|microtubule polymerization or depolymerization|
|regulation of ubiquitin-protein transferase activity|
|syntaxin binding|
|COPII vesicle coating|
|vesicle targeting, rough ER to cis-Golgi|
|organelle disassembly|
|cis-Golgi network|
|vesicle coating|
|COPII-coated vesicle budding|
|vesicle targeting, to, from or within Golgi|
|endoplasmic reticulum-Golgi intermediate compartment membrane|
|mitotic spindle organization|
|mitotic spindle|
|Golgi vesicle budding|
|centrosome cycle|
|negative regulation of autophagy|
|protein polymerization|
|vesicle targeting|
|Golgi cisterna membrane|
|microtubule organizing center organization|
|protein homotetramerization|
|vesicle budding from membrane|
|spindle assembly|
|negative regulation of protein binding|
|microtubule cytoskeleton organization involved in mitosis|
|positive regulation of protein ubiquitination|
|spindle pole|
|Golgi organization|
|positive regulation of protein modification by small protein conjugation or removal|
|mitotic nuclear division|
|protein tetramerization|
|meiotic nuclear division|
|spindle organization|
|meiotic cell cycle process|
|negative regulation of binding|
|establishment of vesicle localization|
|vesicle localization|
|regulation of protein ubiquitination|
|endoplasmic reticulum to Golgi vesicle-mediated transport|
|regulation of protein binding|
|meiotic cell cycle|
|regulation of protein modification by small protein conjugation or removal|
|microtubule binding|
|negative regulation of cellular catabolic process|
|macromolecule glycosylation|
|protein glycosylation|
|glycosylation|
|nuclear division|
|vesicle organization|
|cadherin binding|
|negative regulation of catabolic process|
|organelle fission|
|microtubule|
|glycoprotein biosynthetic process|
|regulation of autophagy|
|protein homooligomerization|
|establishment of organelle localization|
|Golgi vesicle transport|
|regulation of binding|
|glycoprotein metabolic process|
|cellular component disassembly|
|endomembrane system organization|
|supramolecular fiber organization|
|protein kinase binding|
|microtubule cytoskeleton organization|
|cell division|
|protein complex oligomerization|
|organelle localization|
|mitotic cell cycle process|
|carbohydrate derivative biosynthetic process|
|Golgi membrane|
|positive regulation of transferase activity|
|microtubule-based process|
|mitotic cell cycle|
|organelle assembly|
|regulation of cellular catabolic process|
|cellular protein-containing complex assembly|
|membrane organization|
|regulation of transferase activity|
|Golgi apparatus|
|regulation of catabolic process|
|cell cycle process|
|carbohydrate derivative metabolic process|
|identical protein binding|
|cytoskeleton organization|
|negative regulation of molecular function|
|positive regulation of protein modification process|
|cell cycle|
|organonitrogen compound biosynthetic process|
|reproductive process|
|reproduction|
|positive regulation of catalytic activity|
|protein transport|
|intracellular transport|
|peptide transport|
|protein-containing complex assembly|
|amide transport|
|positive regulation of cellular protein metabolic process|
|establishment of protein localization|
|positive regulation of protein metabolic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|positive regulation of molecular function|
|establishment of localization in cell|
|regulation of protein modification process|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|positive regulation of macromolecule biosynthetic process|
|vesicle-mediated transport|
|positive regulation of cellular biosynthetic process|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|-2.75|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|-2.08|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|-2.06|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-1.74|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:a:amfr|AMFR]]|0.422|
|[[:human genes:p:prim1|PRIM1]]|0.417|
|[[:human genes:a:atp6v1a|ATP6V1A]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3817
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.52 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GOLGA2 Expression in NALM6 Cells: 6.52'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>