GOLGA8K [The Human Chemical-Genetic Interaction Map Project]

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======= GOLGA8K =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GOLGA8K
  * **<color #00a2e8>Official Name</color>**: golgin A8 family member K
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=653125|653125]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/D6RF30|D6RF30]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GOLGA8K&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GOLGA8K|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**:  N/A

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Golgi cis cisterna|
|cis-Golgi network|
|Golgi cisterna membrane|
|spindle assembly|
|Golgi organization|
|spindle organization|
|endomembrane system organization|
|microtubule cytoskeleton organization|
|microtubule-based process|
|organelle assembly|
|Golgi apparatus|
|cell cycle process|
|cytoskeleton organization|
|cell cycle|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|-1.74|
|[[:results:exp237|NN-Diethyl-meta-toluamide 100μM R05 exp237]]|1.76|
|[[:results:exp418|Tunicamycin 0.04μM R07 exp418]]|2.06|
|[[:results:exp239|PFI-2 4μM R05 exp239]]|2.17|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:pola1|POLA1]]|0.437|
|[[:human genes:d:dimt1|DIMT1]]|0.433|
|[[:human genes:c:c14orf93|C14orf93]]|0.428|
|[[:human genes:s:supt5h|SUPT5H]]|0.425|
|[[:human genes:n:nupl1|NUPL1]]|0.422|
|[[:human genes:r:rps2|RPS2]]|0.421|
|[[:human genes:a:ahctf1|AHCTF1]]|0.42|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.418|
|[[:human genes:e:eftud2|EFTUD2]]|0.415|
|[[:human genes:p:psmd2|PSMD2]]|0.413|
|[[:human genes:r:rrp7a|RRP7A]]|0.41|
|[[:human genes:n:nbpf1|NBPF1]]|0.409|
|[[:human genes:s:slc38a7|SLC38A7]]|0.409|
|[[:human genes:d:dtl|DTL]]|0.408|
|[[:human genes:t:tuba8|TUBA8]]|0.407|
|[[:human genes:r:rps12|RPS12]]|0.407|
|[[:human genes:b:bysl|BYSL]]|0.406|
|[[:human genes:s:ssh2|SSH2]]|0.406|
|[[:human genes:r:rpl35|RPL35]]|0.405|
|[[:human genes:p:plk4|PLK4]]|0.403|
|[[:human genes:h:hist1h2be|HIST1H2BE]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 37/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|3/28|
|blood|5/28|
|bone|0/26|
|breast|2/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|4/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|1/21|
|liver|1/20|
|lung|3/75|
|lymphocyte|1/16|
|ovary|0/26|
|pancreas|2/24|
|peripheral nervous system|0/16|
|plasma cell|2/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|2/29|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1907
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.62 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GOLGA8K Expression in NALM6 Cells: -0.62'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>