GOLPH3 [The Human Chemical-Genetic Interaction Map Project]

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======= GOLPH3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GOLPH3
  * **<color #00a2e8>Official Name</color>**: golgi phosphoprotein 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=64083|64083]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H4A6|Q9H4A6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GOLPH3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GOLPH3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612207|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Phosphatidylinositol-4-phosphate-binding protein that links Golgi membranes to the cytoskeleton and may participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus. May also bind to the coatomer to regulate Golgi membrane trafficking. May play a role in anterograde transport from the Golgi to the plasma membrane and regulate secretion. Has also been involved in the control of the localization of Golgi enzymes through interaction with their cytoplasmic part. May play an indirect role in cell migration. Has also been involved in the modulation of mTOR signaling. May also be involved in the regulation of mitochondrial lipids biosynthesis. {ECO:0000269|PubMed:16263763, ECO:0000269|PubMed:19553991, ECO:0000269|PubMed:19837035, ECO:0000269|PubMed:22745132, ECO:0000269|PubMed:23027862, ECO:0000269|PubMed:23345592, ECO:0000269|PubMed:23500462}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|GPP34|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|asymmetric Golgi ribbon formation|
|cell adhesion molecule production|
|protein retention in Golgi apparatus|
|Golgi cisterna|
|Golgi ribbon formation|
|leukocyte tethering or rolling|
|leukocyte adhesion to vascular endothelial cell|
|protein localization to Golgi apparatus|
|phosphatidylinositol-4-phosphate binding|
|establishment of epithelial cell polarity|
|lamellipodium assembly|
|Golgi to plasma membrane protein transport|
|positive regulation of TOR signaling|
|cellular extravasation|
|lamellipodium organization|
|leukocyte cell-cell adhesion|
|establishment of protein localization to plasma membrane|
|Golgi to plasma membrane transport|
|maintenance of protein location in cell|
|mitochondrial intermembrane space|
|Golgi vesicle budding|
|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|
|Golgi cisterna membrane|
|vesicle-mediated transport to the plasma membrane|
|maintenance of location in cell|
|vesicle budding from membrane|
|post-Golgi vesicle-mediated transport|
|regulation of TOR signaling|
|maintenance of protein location|
|establishment of cell polarity|
|Golgi organization|
|protein secretion|
|establishment of protein localization to extracellular region|
|maintenance of location|
|protein localization to extracellular region|
|trans-Golgi network|
|peptide secretion|
|regulation of mitochondrion organization|
|protein localization to plasma membrane|
|establishment or maintenance of cell polarity|
|protein localization to cell periphery|
|establishment of protein localization to membrane|
|endosome|
|positive regulation of protein secretion|
|positive regulation of peptide secretion|
|vesicle organization|
|glycoprotein biosynthetic process|
|enzyme binding|
|Golgi vesicle transport|
|leukocyte migration|
|glycoprotein metabolic process|
|positive regulation of secretion by cell|
|endomembrane system organization|
|positive regulation of protein transport|
|positive regulation of secretion|
|plasma membrane bounded cell projection assembly|
|cell projection assembly|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|protein localization to membrane|
|regulation of peptide secretion|
|cell-cell adhesion|
|cell population proliferation|
|carbohydrate derivative biosynthetic process|
|intracellular membrane-bounded organelle|
|regulation of protein transport|
|protein localization to organelle|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of secretion|
|membrane organization|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|cell adhesion|
|biological adhesion|
|cell migration|
|Golgi apparatus|
|positive regulation of transport|
|negative regulation of cell death|
|secretion by cell|
|positive regulation of intracellular signal transduction|
|regulation of protein localization|
|carbohydrate derivative metabolic process|
|export from cell|
|cell motility|
|localization of cell|
|secretion|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|mitochondrion|
|regulation of organelle organization|
|locomotion|
|organonitrogen compound biosynthetic process|
|protein transport|
|peptide transport|
|regulation of apoptotic process|
|movement of cell or subcellular component|
|regulation of programmed cell death|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|positive regulation of signal transduction|
|regulation of cell death|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|nitrogen compound transport|
|regulation of transport|
|vesicle-mediated transport|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp79|Q15 2.7μM R02 exp79]]|-1.82|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|-1.76|
|[[:results:exp352|Dexamethasone 0.006 to 0.015μM on day4 R07 exp352]]|1.88|
|[[:results:exp419|Tunicamycin 0.04 to 0.075μM  on day4 R07 exp419]]|2.01|
|[[:results:exp372|Ibrutinib 1μM R07 exp372]]|2.09|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:cdh3|CDH3]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5180
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.58 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GOLPH3 Expression in NALM6 Cells: 5.58'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>