GOPC [The Human Chemical-Genetic Interaction Map Project]

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======= GOPC =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GOPC
  * **<color #00a2e8>Official Name</color>**: golgi associated PDZ and coiled-coil motif containing
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=57120|57120]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9HD26|Q9HD26]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GOPC&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GOPC|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606845|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a role in intracellular protein trafficking and degradation. May regulate CFTR chloride currents and acid-induced ASIC3 currents by modulating cell surface expression of both channels. May also regulate the intracellular trafficking of the ADR1B receptor. May play a role in autophagy. Overexpression results in CFTR intracellular retention and degradation in the lysosomes. {ECO:0000269|PubMed:11707463, ECO:0000269|PubMed:14570915, ECO:0000269|PubMed:15358775}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PDZ|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of Golgi to plasma membrane CFTR protein transport|
|regulation of Golgi to plasma membrane CFTR protein transport|
|cytoplasmic sequestering of CFTR protein|
|negative regulation of anion channel activity|
|negative regulation of Golgi to plasma membrane protein transport|
|regulation of Golgi to plasma membrane protein transport|
|regulation of anion channel activity|
|apical protein localization|
|negative regulation of protein localization to cell surface|
|negative regulation of anion transmembrane transport|
|trans-Golgi network transport vesicle|
|Golgi-associated vesicle membrane|
|negative regulation of protein localization to plasma membrane|
|negative regulation of protein localization to cell periphery|
|cytoplasmic sequestering of protein|
|regulation of anion transmembrane transport|
|negative regulation of anion transport|
|negative regulation of protein localization to membrane|
|regulation of protein localization to cell surface|
|Golgi to plasma membrane transport|
|negative regulation of ion transmembrane transporter activity|
|negative regulation of transporter activity|
|vesicle-mediated transport to the plasma membrane|
|regulation of protein localization to plasma membrane|
|regulation of anion transport|
|negative regulation of ion transmembrane transport|
|post-Golgi vesicle-mediated transport|
|maintenance of protein location|
|negative regulation of cellular protein localization|
|regulation of protein localization to cell periphery|
|negative regulation of transmembrane transport|
|ion channel binding|
|negative regulation of ion transport|
|maintenance of location|
|negative regulation of protein transport|
|negative regulation of establishment of protein localization|
|regulation of protein localization to membrane|
|postsynaptic membrane|
|endoplasmic reticulum to Golgi vesicle-mediated transport|
|postsynaptic density|
|regulation of ion transmembrane transporter activity|
|regulation of transmembrane transporter activity|
|regulation of transporter activity|
|lysosomal membrane|
|protein homooligomerization|
|Golgi vesicle transport|
|dendrite|
|regulation of ion transmembrane transport|
|negative regulation of transport|
|protein complex oligomerization|
|regulation of cellular protein localization|
|cell junction|
|regulation of vesicle-mediated transport|
|regulation of transmembrane transport|
|protein-containing complex|
|Golgi membrane|
|regulation of ion transport|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of cellular localization|
|Golgi apparatus|
|regulation of protein localization|
|negative regulation of molecular function|
|protein transport|
|intracellular transport|
|peptide transport|
|protein-containing complex assembly|
|amide transport|
|establishment of protein localization|
|establishment of localization in cell|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|regulation of transport|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp189|Temozolomide 200μM R04 exp189]]|-1.89|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|1.74|
|[[:results:exp432|YM155 0.001μM R08 exp432]]|1.85|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13468
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.34 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GOPC Expression in NALM6 Cells: 6.34'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>