GOT2 [The Human Chemical-Genetic Interaction Map Project]

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======= GOT2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GOT2
  * **<color #00a2e8>Official Name</color>**: glutamic-oxaloacetic transaminase 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2806|2806]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P00505|P00505]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GOT2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GOT2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/138150|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the irreversible transamination of the L- tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids. {ECO:0000269|PubMed:9537447}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Aminotran 1 2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|glutamate catabolic process to 2-oxoglutarate|
|glutamate catabolic process to aspartate|
|fumarate metabolic process|
|aspartate biosynthetic process|
|L-aspartate:2-oxoglutarate aminotransferase activity|
|4-hydroxyproline catabolic process|
|kynurenine-oxoglutarate transaminase activity|
|aspartate catabolic process|
|L-kynurenine metabolic process|
|oxaloacetate metabolic process|
|glutamate catabolic process|
|aspartate metabolic process|
|glyoxylate metabolic process|
|kynurenine metabolic process|
|dicarboxylic acid biosynthetic process|
|4-hydroxyproline metabolic process|
|2-oxoglutarate metabolic process|
|amino acid binding|
|dicarboxylic acid catabolic process|
|aspartate family amino acid catabolic process|
|aspartate family amino acid biosynthetic process|
|response to muscle activity|
|benzene-containing compound metabolic process|
|glutamine family amino acid catabolic process|
|cellular modified amino acid catabolic process|
|glutamate metabolic process|
|response to isoquinoline alkaloid|
|response to morphine|
|T-tubule|
|gluconeogenesis|
|lactation|
|hexose biosynthetic process|
|aspartate family amino acid metabolic process|
|monosaccharide biosynthetic process|
|cellular aldehyde metabolic process|
|pyridoxal phosphate binding|
|response to activity|
|alpha-amino acid biosynthetic process|
|glutamine family amino acid metabolic process|
|cellular ketone metabolic process|
|fatty acid transport|
|body fluid secretion|
|response to anesthetic|
|cellular amino acid biosynthetic process|
|dicarboxylic acid metabolic process|
|phospholipid binding|
|alpha-amino acid catabolic process|
|response to alkaloid|
|glucose metabolic process|
|cellular amino acid catabolic process|
|carbohydrate biosynthetic process|
|response to ethanol|
|mammary gland development|
|perikaryon|
|monocarboxylic acid transport|
|hexose metabolic process|
|female pregnancy|
|response to ammonium ion|
|cellular modified amino acid metabolic process|
|monosaccharide metabolic process|
|alpha-amino acid metabolic process|
|multi-multicellular organism process|
|response to insulin|
|response to alcohol|
|organic acid catabolic process|
|carboxylic acid catabolic process|
|carboxylic acid transport|
|organic acid transport|
|lipid transport|
|response to xenobiotic stimulus|
|carboxylic acid biosynthetic process|
|organic acid biosynthetic process|
|response to antibiotic|
|cellular amino acid metabolic process|
|lipid localization|
|enzyme binding|
|mitochondrial matrix|
|response to peptide hormone|
|mitochondrial inner membrane|
|gland development|
|small molecule catabolic process|
|cofactor metabolic process|
|organic anion transport|
|response to peptide|
|carbohydrate metabolic process|
|regulation of body fluid levels|
|response to toxic substance|
|monocarboxylic acid metabolic process|
|anion transport|
|small molecule biosynthetic process|
|protein-containing complex|
|cell surface|
|protein homodimerization activity|
|response to hormone|
|carboxylic acid metabolic process|
|response to organic cyclic compound|
|multi-organism reproductive process|
|response to organonitrogen compound|
|oxoacid metabolic process|
|response to drug|
|organic acid metabolic process|
|organonitrogen compound catabolic process|
|response to nitrogen compound|
|secretion|
|mitochondrion|
|ion transport|
|RNA binding|
|organonitrogen compound biosynthetic process|
|reproductive process|
|reproduction|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|-2.38|
|[[:results:exp272|CHIR-124 0.04μM R06 exp272]]|-2.2|
|[[:results:exp156|UNC2400 2μM R03 exp156]]|-1.93|
|[[:results:exp232|Epothilone-D 0.004 to 0.006μM on day4 R05 exp232]]|-1.87|
|[[:results:exp464|Calcipotriol 5μM R08 exp464]]|-1.86|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|1.7|
|[[:results:exp419|Tunicamycin 0.04 to 0.075μM  on day4 R07 exp419]]|1.71|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|1.73|
|[[:results:exp13|Chloramphenicol 20μM R00 exp13]]|1.78|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|1.8|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|1.81|
|[[:results:exp392|PT-1 25μM R07 exp392]]|1.95|
|[[:results:exp160|Ribavirin 10 to 15μM on day4 R04 exp160]]|1.96|
|[[:results:exp483|FTY720 3μM R08 exp483]]|2.07|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|2.21|
|[[:results:exp415|Trichostatin-A 0.06μM R07 exp415]]|2.22|
|[[:results:exp189|Temozolomide 200μM R04 exp189]]|2.98|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:mdh2|MDH2]]|0.467|
|[[:human genes:e:ecsit|ECSIT]]|0.435|
|[[:human genes:r:rbfa|RBFA]]|0.424|
|[[:human genes:a:abhd11|ABHD11]]|0.421|
|[[:human genes:c:c16orf80|C16orf80]]|0.419|
|[[:human genes:f:fkbpl|FKBPL]]|0.414|
|[[:human genes:m:mcat|MCAT]]|0.408|
|[[:human genes:n:ndufa2|NDUFA2]]|0.406|
|[[:human genes:m:mto1|MTO1]]|0.405|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 5/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|2/28|
|bone|0/25|
|breast|0/33|
|central nervous system|1/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|1/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2077
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.35 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GOT2 Expression in NALM6 Cells: 7.35'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>