GP1BA [The Human Chemical-Genetic Interaction Map Project]

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======= GP1BA =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GP1BA
  * **<color #00a2e8>Official Name</color>**: glycoprotein Ib platelet subunit alpha
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2811|2811]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P07359|P07359]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GP1BA&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GP1BA|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606672|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Glycoprotein Ib (GP Ib) is a platelet surface membrane glycoprotein composed of a heterodimer, an alpha chain and a beta chain, that is linked by disulfide bonds. The Gp Ib functions as a receptor for von Willebrand factor (VWF). The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX and platelet glycoprotein V. The binding of the GP Ib-IX-V complex to VWF facilitates initial platelet adhesion to vascular subendothelium after vascular injury, and also initiates signaling events within the platelet that lead to enhanced platelet activation, thrombosis, and hemostasis. This gene encodes the alpha subunit. Mutations in this gene result in Bernard-Soulier syndromes and platelet-type von Willebrand disease. The coding region of this gene is known to contain a polymophic variable number tandem repeat (VNTR) domain that is associated with susceptibility to nonarteritic anterior ischemic optic neuropathy. [provided by RefSeq, Oct 2013]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|LRRNT|
|LRR 4|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|thrombin-activated receptor activity|
|thrombin-activated receptor signaling pathway|
|blood coagulation, intrinsic pathway|
|anchored component of external side of plasma membrane|
|fibrinolysis|
|protein activation cascade|
|blood coagulation, fibrin clot formation|
|platelet aggregation|
|negative regulation of blood coagulation|
|negative regulation of hemostasis|
|negative regulation of coagulation|
|regulation of megakaryocyte differentiation|
|homotypic cell-cell adhesion|
|negative regulation of wound healing|
|regulation of blood coagulation|
|regulation of hemostasis|
|regulation of coagulation|
|negative regulation of response to wounding|
|regulation of wound healing|
|platelet activation|
|regulation of response to wounding|
|regulation of myeloid cell differentiation|
|extracellular matrix|
|blood coagulation|
|coagulation|
|hemostasis|
|negative regulation of response to external stimulus|
|regulation of hemopoiesis|
|wound healing|
|regulation of body fluid levels|
|cell-cell adhesion|
|response to wounding|
|cell surface|
|cell morphogenesis|
|cellular component morphogenesis|
|cell adhesion|
|biological adhesion|
|cell activation|
|regulation of response to external stimulus|
|negative regulation of multicellular organismal process|
|G protein-coupled receptor signaling pathway|
|integral component of plasma membrane|
|regulation of response to stress|
|extracellular space|
|negative regulation of response to stimulus|
|regulation of immune system process|
|regulation of cell differentiation|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp155|UNC1999 2μM R03 exp155]]|-1.97|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|-1.94|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|1.87|
|[[:results:exp144|PFI-3 10μM R03 exp144]]|1.88|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2921
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.02 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GP1BA Expression in NALM6 Cells: 3.02'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>