GPC2 [The Human Chemical-Genetic Interaction Map Project]

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======= GPC2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GPC2
  * **<color #00a2e8>Official Name</color>**: glypican 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=221914|221914]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8N158|Q8N158]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GPC2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GPC2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/618446|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Cell surface proteoglycan that bears heparan sulfate. May fulfill a function related to the motile behaviors of developing neurons (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Glypican|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|anchored component of plasma membrane|
|glycosaminoglycan catabolic process|
|aminoglycan catabolic process|
|smoothened signaling pathway|
|lysosomal lumen|
|Golgi lumen|
|glycosaminoglycan biosynthetic process|
|retinoid metabolic process|
|aminoglycan biosynthetic process|
|diterpenoid metabolic process|
|terpenoid metabolic process|
|isoprenoid metabolic process|
|glycosaminoglycan metabolic process|
|aminoglycan metabolic process|
|regulation of protein localization to membrane|
|carbohydrate derivative catabolic process|
|synapse|
|positive regulation of neuron projection development|
|collagen-containing extracellular matrix|
|positive regulation of neuron differentiation|
|positive regulation of cell projection organization|
|positive regulation of neurogenesis|
|regulation of neuron projection development|
|positive regulation of nervous system development|
|regulation of cellular protein localization|
|positive regulation of cell development|
|cell surface|
|carbohydrate derivative biosynthetic process|
|regulation of neuron differentiation|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cell projection organization|
|regulation of neurogenesis|
|regulation of cellular localization|
|regulation of nervous system development|
|regulation of cell development|
|cellular lipid metabolic process|
|cell migration|
|positive regulation of cell differentiation|
|endoplasmic reticulum|
|neuron differentiation|
|regulation of protein localization|
|carbohydrate derivative metabolic process|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|localization of cell|
|cell motility|
|positive regulation of cellular component organization|
|lipid metabolic process|
|locomotion|
|positive regulation of developmental process|
|organonitrogen compound biosynthetic process|
|generation of neurons|
|movement of cell or subcellular component|
|extracellular space|
|neurogenesis|
|positive regulation of multicellular organismal process|
|macromolecule biosynthetic process|
|organic substance catabolic process|
|regulation of cell differentiation|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp132|Metformin 40μM R03 exp132]]|-1.82|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|-1.78|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|1.93|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4729
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.34 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GPC2 Expression in NALM6 Cells: 4.34'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>