GPIHBP1 [The Human Chemical-Genetic Interaction Map Project]

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======= GPIHBP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GPIHBP1
  * **<color #00a2e8>Official Name</color>**: glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=338328|338328]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8IV16|Q8IV16]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GPIHBP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GPIHBP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612757|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a capillary endothelial cell protein that facilitates the lipolytic processing of triglyceride-rich lipoproteins. The encoded protein is a glycosylphosphatidylinositol-anchored protein that is a member of the lymphocyte antigen 6 (Ly6) family. This protein plays a major role in transporting lipoprotein lipase (LPL) from the subendothelial spaces to the capillary lumen. Mutations in this gene are the cause of hyperlipoproteinemia, type 1D. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a key role in the lipolytic processing of chylomicrons. Required for the transport of lipoprotein lipase LPL into the capillary lumen (By similarity). {ECO:0000250}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of chylomicron remnant clearance|
|regulation of chylomicron remnant clearance|
|chylomicron binding|
|response to heparin|
|positive regulation of lipoprotein particle clearance|
|lipase binding|
|lipoprotein particle binding|
|response to anticoagulant|
|chylomicron remodeling|
|positive regulation of lipoprotein lipase activity|
|positive regulation of triglyceride lipase activity|
|triglyceride-rich lipoprotein particle remodeling|
|transcytosis|
|regulation of lipoprotein particle clearance|
|protein transmembrane transporter activity|
|anchored component of external side of plasma membrane|
|regulation of lipoprotein lipase activity|
|protein localization to cell surface|
|protein-lipid complex remodeling|
|plasma lipoprotein particle remodeling|
|protein-containing complex remodeling|
|acylglycerol homeostasis|
|triglyceride homeostasis|
|plasma lipoprotein particle organization|
|protein-lipid complex subunit organization|
|protein transmembrane transport|
|positive regulation of lipase activity|
|regulation of plasma lipoprotein particle levels|
|cholesterol homeostasis|
|sterol homeostasis|
|regulation of lipase activity|
|anchored component of membrane|
|retinoid metabolic process|
|diterpenoid metabolic process|
|terpenoid metabolic process|
|lipid homeostasis|
|isoprenoid metabolic process|
|protein import|
|lipid binding|
|protein stabilization|
|basolateral plasma membrane|
|regulation of protein stability|
|apical plasma membrane|
|extracellular structure organization|
|external side of plasma membrane|
|positive regulation of hydrolase activity|
|cellular lipid metabolic process|
|intracellular protein transport|
|response to organonitrogen compound|
|response to drug|
|response to nitrogen compound|
|chemical homeostasis|
|lipid metabolic process|
|transmembrane transport|
|regulation of hydrolase activity|
|positive regulation of catalytic activity|
|protein transport|
|intracellular transport|
|peptide transport|
|response to oxygen-containing compound|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|homeostatic process|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|establishment of localization in cell|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|extracellular region|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|-1.71|
|[[:results:exp289|Hydroxyurea 15μM R06 exp289]]|1.8|
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|2.21|
|[[:results:exp348|Cyclosporin-A 3μM R07 exp348]]|2.27|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rab34|RAB34]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3030
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.25 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GPIHBP1 Expression in NALM6 Cells: 2.25'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>