GPLD1 [The Human Chemical-Genetic Interaction Map Project]

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======= GPLD1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GPLD1
  * **<color #00a2e8>Official Name</color>**: glycosylphosphatidylinositol specific phospholipase D1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2822|2822]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P80108|P80108]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GPLD1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GPLD1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602515|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Many proteins are tethered to the extracellular face of eukaryotic plasma membranes by a glycosylphosphatidylinositol (GPI) anchor. The GPI-anchor is a glycolipid found on many blood cells. The protein encoded by this gene is a GPI degrading enzyme. Glycosylphosphatidylinositol specific phospholipase D1 hydrolyzes the inositol phosphate linkage in proteins anchored by phosphatidylinositol glycans, thereby releasing the attached protein from the plasma membrane. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|FG-GAP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|GPI anchor release|
|glycosylphosphatidylinositol phospholipase D activity|
|response to triglyceride|
|cellular response to triglyceride|
|hematopoietic stem cell migration to bone marrow|
|positive regulation of high-density lipoprotein particle clearance|
|regulation of high-density lipoprotein particle clearance|
|hematopoietic stem cell migration|
|negative regulation of triglyceride catabolic process|
|C-terminal protein lipidation|
|positive regulation of lipoprotein particle clearance|
|positive regulation of alkaline phosphatase activity|
|phospholipase D activity|
|regulation of alkaline phosphatase activity|
|negative regulation of triglyceride metabolic process|
|positive regulation of cytolysis|
|regulation of triglyceride catabolic process|
|positive regulation of triglyceride biosynthetic process|
|complement receptor mediated signaling pathway|
|C-terminal protein amino acid modification|
|positive regulation of membrane protein ectodomain proteolysis|
|cellular response to cholesterol|
|regulation of triglyceride biosynthetic process|
|regulation of cytolysis|
|transepithelial transport|
|regulation of lipoprotein particle clearance|
|positive regulation of triglyceride metabolic process|
|cellular response to sterol|
|cell migration involved in sprouting angiogenesis|
|negative regulation of lipid catabolic process|
|regulation of membrane protein ectodomain proteolysis|
|cellular response to pH|
|response to cholesterol|
|blood vessel endothelial cell migration|
|response to sterol|
|GPI anchor metabolic process|
|positive regulation of insulin secretion involved in cellular response to glucose stimulus|
|positive regulation of phosphatase activity|
|sodium channel regulator activity|
|regulation of triglyceride metabolic process|
|positive regulation of glucose metabolic process|
|response to pH|
|regulation of lipid catabolic process|
|regulation of insulin secretion involved in cellular response to glucose stimulus|
|sprouting angiogenesis|
|positive regulation of dephosphorylation|
|positive regulation of cellular carbohydrate metabolic process|
|endothelial cell migration|
|positive regulation of insulin secretion|
|regulation of cellular response to insulin stimulus|
|phosphatidylcholine metabolic process|
|positive regulation of lipid biosynthetic process|
|positive regulation of carbohydrate metabolic process|
|negative regulation of lipid metabolic process|
|chondrocyte differentiation|
|epithelial cell migration|
|cellular response to calcium ion|
|cellular response to alcohol|
|protein lipidation|
|epithelium migration|
|insulin receptor signaling pathway|
|lipoprotein biosynthetic process|
|tissue migration|
|positive regulation of peptide hormone secretion|
|positive regulation of endothelial cell migration|
|glycolipid metabolic process|
|liposaccharide metabolic process|
|regulation of glucose metabolic process|
|lipoprotein metabolic process|
|positive regulation of hormone secretion|
|positive regulation of small molecule metabolic process|
|response to glucose|
|regulation of cellular carbohydrate metabolic process|
|positive regulation of epithelial cell migration|
|positive regulation of lipid metabolic process|
|response to hexose|
|response to monosaccharide|
|response to calcium ion|
|regulation of endothelial cell migration|
|cellular response to insulin stimulus|
|phosphatidylinositol metabolic process|
|response to carbohydrate|
|ameboidal-type cell migration|
|cartilage development|
|regulation of phosphatase activity|
|regulation of insulin secretion|
|regulation of lipid biosynthetic process|
|cellular response to metal ion|
|ammonium ion metabolic process|
|membrane lipid metabolic process|
|regulation of carbohydrate metabolic process|
|regulation of peptide hormone secretion|
|regulation of dephosphorylation|
|positive regulation of protein catabolic process|
|regulation of epithelial cell migration|
|cellular response to inorganic substance|
|connective tissue development|
|response to insulin|
|extracellular matrix|
|response to alcohol|
|negative regulation of cellular catabolic process|
|ossification|
|cellular response to peptide hormone stimulus|
|regulation of hormone secretion|
|positive regulation of protein secretion|
|positive regulation of peptide secretion|
|lysosomal membrane|
|glycerophospholipid metabolic process|
|negative regulation of catabolic process|
|cellular response to abiotic stimulus|
|cellular response to environmental stimulus|
|angiogenesis|
|cellular response to peptide|
|positive regulation of proteolysis|
|post-translational protein modification|
|positive regulation of cellular catabolic process|
|response to metal ion|
|phospholipid metabolic process|
|glycerolipid metabolic process|
|regulation of protein catabolic process|
|response to peptide hormone|
|regulation of lipid metabolic process|
|cellular response to drug|
|positive regulation of secretion by cell|
|blood vessel morphogenesis|
|positive regulation of protein transport|
|regulation of small molecule metabolic process|
|positive regulation of catabolic process|
|positive regulation of secretion|
|immune response-activating cell surface receptor signaling pathway|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|response to peptide|
|immune response-regulating cell surface receptor signaling pathway|
|blood vessel development|
|regulation of peptide secretion|
|skeletal system development|
|positive regulation of cell migration|
|vasculature development|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|cardiovascular system development|
|cellular response to lipid|
|positive regulation of cell motility|
|response to inorganic substance|
|regulation of hormone levels|
|positive regulation of cellular component movement|
|cellular response to organic cyclic compound|
|positive regulation of locomotion|
|immune response-activating signal transduction|
|immune response-regulating signaling pathway|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|activation of immune response|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|tube morphogenesis|
|cellular response to nitrogen compound|
|negative regulation of cell population proliferation|
|intracellular membrane-bounded organelle|
|positive regulation of cell death|
|regulation of protein transport|
|enzyme linked receptor protein signaling pathway|
|regulation of proteolysis|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|positive regulation of hydrolase activity|
|regulation of secretion|
|regulation of cellular catabolic process|
|tube development|
|regulation of cell migration|
|response to lipid|
|positive regulation of immune response|
|circulatory system development|
|organophosphate metabolic process|
|anatomical structure formation involved in morphogenesis|
|response to hormone|
|regulation of cell motility|
|regulation of cellular localization|
|response to organic cyclic compound|
|cellular lipid metabolic process|
|cell migration|
|regulation of locomotion|
|positive regulation of transport|
|regulation of cellular component movement|
|regulation of catabolic process|
|response to organonitrogen compound|
|response to drug|
|regulation of protein localization|
|carbohydrate derivative metabolic process|
|cellular response to oxygen-containing compound|
|cell motility|
|localization of cell|
|response to nitrogen compound|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|regulation of immune response|
|positive regulation of immune system process|
|response to abiotic stimulus|
|lipid metabolic process|
|cellular response to endogenous stimulus|
|regulation of hydrolase activity|
|locomotion|
|organonitrogen compound biosynthetic process|
|positive regulation of catalytic activity|
|response to endogenous stimulus|
|regulation of apoptotic process|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|regulation of immune system process|
|regulation of cell death|
|positive regulation of protein metabolic process|
|cellular macromolecule biosynthetic process|
|positive regulation of multicellular organismal process|
|tissue development|
|macromolecule biosynthetic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of transport|
|extracellular region|
|positive regulation of cellular biosynthetic process|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|1.78|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.417|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9392
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.37 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GPLD1 Expression in NALM6 Cells: 3.37'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>