GPNMB [The Human Chemical-Genetic Interaction Map Project]

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======= GPNMB =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GPNMB
  * **<color #00a2e8>Official Name</color>**: glycoprotein nmb
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10457|10457]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q14956|Q14956]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GPNMB&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GPNMB|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604368|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Could be a melanogenic enzyme. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PKD|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|syndecan binding|
|melanosome membrane|
|positive regulation of protein autophosphorylation|
|receptor ligand activity|
|chemoattractant activity|
|regulation of protein autophosphorylation|
|bone mineralization|
|positive chemotaxis|
|negative regulation of tumor necrosis factor production|
|negative regulation of T cell proliferation|
|negative regulation of tumor necrosis factor superfamily cytokine production|
|regulation of tissue remodeling|
|negative regulation of mononuclear cell proliferation|
|negative regulation of lymphocyte proliferation|
|negative regulation of leukocyte proliferation|
|biomineralization|
|biomineral tissue development|
|negative regulation of G1/S transition of mitotic cell cycle|
|negative regulation of cell cycle G1/S phase transition|
|negative regulation of T cell activation|
|negative regulation of leukocyte cell-cell adhesion|
|osteoblast differentiation|
|integrin binding|
|negative regulation of lymphocyte activation|
|regulation of tumor necrosis factor production|
|regulation of G1/S transition of mitotic cell cycle|
|regulation of tumor necrosis factor superfamily cytokine production|
|early endosome membrane|
|regulation of T cell proliferation|
|regulation of cell cycle G1/S phase transition|
|heparin binding|
|negative regulation of cell-cell adhesion|
|negative regulation of leukocyte activation|
|negative regulation of cell activation|
|negative regulation of neuron death|
|regulation of lymphocyte proliferation|
|regulation of mononuclear cell proliferation|
|positive regulation of ERK1 and ERK2 cascade|
|negative regulation of mitotic cell cycle phase transition|
|regulation of leukocyte proliferation|
|negative regulation of cell cycle phase transition|
|ossification|
|negative regulation of cell adhesion|
|negative regulation of cytokine production|
|regulation of angiogenesis|
|regulation of ERK1 and ERK2 cascade|
|regulation of leukocyte cell-cell adhesion|
|negative regulation of mitotic cell cycle|
|regulation of neuron death|
|regulation of T cell activation|
|regulation of vasculature development|
|negative regulation of cell cycle process|
|regulation of cell-cell adhesion|
|regulation of mitotic cell cycle phase transition|
|negative regulation of immune system process|
|regulation of cell cycle phase transition|
|positive regulation of cell migration|
|regulation of lymphocyte activation|
|positive regulation of cell motility|
|positive regulation of cellular component movement|
|positive regulation of MAPK cascade|
|chemotaxis|
|positive regulation of locomotion|
|taxis|
|negative regulation of cell cycle|
|regulation of leukocyte activation|
|regulation of mitotic cell cycle|
|regulation of cell activation|
|negative regulation of cell population proliferation|
|regulation of cell adhesion|
|regulation of cytokine production|
|regulation of MAPK cascade|
|regulation of cell cycle process|
|regulation of cell migration|
|regulation of cell motility|
|cell adhesion|
|biological adhesion|
|regulation of locomotion|
|negative regulation of cell death|
|regulation of cellular component movement|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|cell-cell signaling|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|regulation of cell cycle|
|negative regulation of multicellular organismal process|
|positive regulation of protein modification process|
|locomotion|
|integral component of plasma membrane|
|regulation of protein phosphorylation|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|regulation of immune system process|
|positive regulation of signal transduction|
|regulation of cell death|
|positive regulation of protein metabolic process|
|tissue development|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp391|Pomalidomide 20μM R07 exp391]]|-2.27|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|-2.26|
|[[:results:exp405|Tenofovir 10μM R07 exp405]]|-1.91|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|-1.9|
|[[:results:exp277|Curcumin 6.5μM R06 exp277]]|-1.85|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|-1.81|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|-1.78|
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|-1.77|
|[[:results:exp462|Cadmium 60μM R08 exp462]]|-1.75|
|[[:results:exp278|CVT-10216 0.1μM R06 exp278]]|-1.71|
|[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|1.97|
|[[:results:exp123|GSK-LSD1 10μM R03 exp123]]|2.08|
|[[:results:exp356|Docosahexaenoic-acid 50μM R07 exp356]]|2.26|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|2.35|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|2.54|
|[[:results:exp420|Tunicamycin 0.04 to 0.125μM  on day4 R07 exp420]]|2.62|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|2.91|
|[[:results:exp111|R-DABN 8μM R03 exp111]]|3.04|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|3.41|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hars|HARS]]|0.425|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11173
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.93 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GPNMB Expression in NALM6 Cells: 1.93'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>