GPR101 [The Human Chemical-Genetic Interaction Map Project]

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======= GPR101 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GPR101
  * **<color #00a2e8>Official Name</color>**: G protein-coupled receptor 101
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=83550|83550]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96P66|Q96P66]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GPR101&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GPR101|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300393|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is an orphan G protein-coupled receptor of unknown function. The encoded protein is a member of a family of proteins that contain seven transmembrane domains and transduce extracellular signals through heterotrimeric G proteins. [provided by RefSeq, Sep 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Orphan receptor.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|7tm 1|
|7TM GPCR Srv|
|7TM GPCR Srsx|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|adrenergic receptor activity|
|adenylate cyclase-activating adrenergic receptor signaling pathway|
|adrenergic receptor signaling pathway|
|adenylate cyclase-activating G protein-coupled receptor signaling pathway|
|cAMP-mediated signaling|
|cyclic-nucleotide-mediated signaling|
|receptor complex|
|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|
|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|
|second-messenger-mediated signaling|
|G protein-coupled receptor signaling pathway|
|integral component of plasma membrane|
|intracellular signal transduction|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp447|Amiloride 100μM R08 exp447]]|-2.32|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|-2.26|
|[[:results:exp379|MSC2530818 10μM R07 exp379]]|-2.09|
|[[:results:exp506|Momordin-Ic 10μM R08 exp506]]|-2.07|
|[[:results:exp521|Salinomycin 3.5μM R08 exp521]]|-2.03|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|-2.02|
|[[:results:exp18|Doxycycline 10μM R00 exp18]]|-1.93|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|-1.85|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|-1.83|
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|-1.79|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|-1.74|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|-1.74|
|[[:results:exp247|UM0130462 0.025 to 0.035μM day4 R05 exp247]]|-1.74|
|[[:results:exp176|Apcin 50 to 100μM on day4 R04 exp176]]|2.01|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/26|
|bone|0/26|
|breast|0/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|0/72|
|lymphocyte|0/16|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18337
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GPR101 Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>