GPR183 [The Human Chemical-Genetic Interaction Map Project]

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======= GPR183 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GPR183
  * **<color #00a2e8>Official Name</color>**: G protein-coupled receptor 183
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1880|1880]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P32249|P32249]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GPR183&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GPR183|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605741|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  G-protein coupled receptor expressed in lymphocytes that acts as a chemotactic receptor for B-cells, T-cells, splenic dendritic cells, monocytes/macrophages and astrocytes (By similarity). Receptor for oxysterol 7-alpha,25- dihydroxycholesterol (7-alpha,25-OHC) and other related oxysterols (PubMed:21796212, PubMed:22875855, PubMed:22930711). Mediates cell positioning and movement of a number of cells by binding the 7- alpha,25-OHC ligand that forms a chemotactic gradient (By similarity). Binding of 7-alpha,25-OHC mediates the correct localization of B-cells during humoral immune responses (By similarity). Guides B-cell movement along the B-cell zone-T-cell zone boundary and later to interfollicular and outer follicular regions (By similarity). Its specific expression during B-cell maturation helps position B-cells appropriately for mounting T- dependent antibody responses (By similarity). Collaborates with CXCR5 to mediate B-cell migration; probably by forming a heterodimer with CXCR5 that affects the interaction between of CXCL13 and CXCR5 (PubMed:22913878). Also acts as a chemotactic receptor for some T-cells upon binding to 7-alpha,25-OHC ligand (By similarity). Promotes follicular helper T (Tfh) cells differentiation by positioning activated T-cells at the follicle- T-zone interface, promoting contact of newly activated CD4 T-cells with activated dendritic cells and exposing them to Tfh-cell- promoting inducible costimulator (ICOS) ligand (By similarity). Expression in splenic dendritic cells is required for their homeostasis, localization and ability to induce B- and T-cell responses: GPR183 acts as a chemotactic receptor in dendritic cells that mediates the accumulation of CD4(+) dendritic cells in bridging channels (By similarity). Regulates migration of astrocytes and is involved in communication between astrocytes and macrophages (PubMed:25297897). Promotes osteoclast precursor migration to bone surfaces (By similarity). Signals constitutively through G(i)-alpha, but not G(s)-alpha or G(q)-alpha (PubMed:21673108, PubMed:25297897). Signals constitutively also via MAPK1/3 (ERK1/2) (By similarity). {ECO:0000250|UniProtKB:Q3U6B2, ECO:0000269|PubMed:16540462, ECO:0000269|PubMed:21673108, ECO:0000269|PubMed:21796212, ECO:0000269|PubMed:22875855, ECO:0000269|PubMed:22913878, ECO:0000269|PubMed:22930711, ECO:0000269|PubMed:25297897}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|7tm 1|
|7TM GPCR Srsx|
|7TM GPCR Srx|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|dendritic cell homeostasis|
|regulation of astrocyte chemotaxis|
|T follicular helper cell differentiation|
|oxysterol binding|
|T cell chemotaxis|
|regulation of glial cell migration|
|mature B cell differentiation involved in immune response|
|dendritic cell chemotaxis|
|dendritic cell migration|
|mature B cell differentiation|
|T-helper cell differentiation|
|CD4-positive, alpha-beta T cell differentiation involved in immune response|
|T cell migration|
|alpha-beta T cell differentiation involved in immune response|
|alpha-beta T cell activation involved in immune response|
|T cell differentiation involved in immune response|
|CD4-positive, alpha-beta T cell differentiation|
|CD4-positive, alpha-beta T cell activation|
|positive regulation of B cell proliferation|
|B cell activation involved in immune response|
|osteoclast differentiation|
|lymphocyte chemotaxis|
|alpha-beta T cell differentiation|
|alpha-beta T cell activation|
|regulation of B cell proliferation|
|T cell activation involved in immune response|
|lymphocyte migration|
|leukocyte homeostasis|
|B cell differentiation|
|lymphocyte activation involved in immune response|
|myeloid leukocyte differentiation|
|regulation of gliogenesis|
|positive regulation of lymphocyte proliferation|
|positive regulation of mononuclear cell proliferation|
|T cell differentiation|
|positive regulation of leukocyte proliferation|
|leukocyte chemotaxis|
|B cell activation|
|positive regulation of B cell activation|
|homeostasis of number of cells|
|regulation of B cell activation|
|regulation of lymphocyte proliferation|
|regulation of mononuclear cell proliferation|
|cell chemotaxis|
|positive regulation of ERK1 and ERK2 cascade|
|regulation of chemotaxis|
|myeloid cell differentiation|
|regulation of leukocyte proliferation|
|T cell activation|
|lymphocyte differentiation|
|regulation of ERK1 and ERK2 cascade|
|leukocyte differentiation|
|humoral immune response|
|positive regulation of lymphocyte activation|
|leukocyte migration|
|lymphocyte activation|
|positive regulation of leukocyte activation|
|positive regulation of cell activation|
|regulation of lymphocyte activation|
|positive regulation of MAPK cascade|
|chemotaxis|
|taxis|
|hemopoiesis|
|regulation of leukocyte activation|
|hematopoietic or lymphoid organ development|
|adaptive immune response|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|regulation of cell activation|
|immune system development|
|G protein-coupled receptor activity|
|regulation of MAPK cascade|
|regulation of neurogenesis|
|regulation of cell migration|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|regulation of nervous system development|
|leukocyte activation|
|regulation of cell development|
|cell migration|
|regulation of locomotion|
|regulation of cellular component movement|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|positive regulation of phosphorylation|
|cell activation|
|localization of cell|
|cell motility|
|immune effector process|
|regulation of response to external stimulus|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|positive regulation of immune system process|
|positive regulation of protein modification process|
|locomotion|
|G protein-coupled receptor signaling pathway|
|integral component of plasma membrane|
|regulation of protein phosphorylation|
|generation of neurons|
|movement of cell or subcellular component|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|neurogenesis|
|homeostatic process|
|regulation of immune system process|
|positive regulation of signal transduction|
|positive regulation of protein metabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|immune response|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp240|Pyridostatin 4μM R05 exp240]]|-1.94|
|[[:results:exp528|TGF-beta1 44ng/ml R08 exp528]]|-1.73|
|[[:results:exp146|Quinacrine 2.5μM R03 exp146]]|2.11|
|[[:results:exp165|RO-3306 3 to 4μM on day4 R04 exp165]]|2.14|
|[[:results:exp15|Cycloheximide 0.2μM R00 exp15]]|2.16|
|[[:results:exp23|Nocodazole 0.02μM R00 exp23]]|2.45|
|[[:results:exp18|Doxycycline 10μM R00 exp18]]|2.5|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17674
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.34 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GPR183 Expression in NALM6 Cells: -1.34'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>