GPR18 [The Human Chemical-Genetic Interaction Map Project]

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======= GPR18 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GPR18
  * **<color #00a2e8>Official Name</color>**: G protein-coupled receptor 18
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2841|2841]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q14330|Q14330]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GPR18&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GPR18|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602042|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Receptor for endocannabinoid N-arachidonyl glycine (NAGly) (PubMed:16844083, PubMed:24762058, PubMed:27572937). However, conflicting results about the role of NAGly as an agonist are reported (PubMed:27018161). Can also be activated by plant- derived and synthetic cannabinoid agonists (PubMed:24762058). The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase (PubMed:16844083). May contribute to regulation of the immune system. Is required for normal homeostasis of CD8+ subsets of intraepithelial lymphocytes (IELs) (CD8alphaalpha and CD8alphabeta IELs)in small intstine by supporting preferential migration of CD8alphaalpha T-cells to intraepithelial compartment over lamina propria compartment, and by mediating their reconstitution into small intestine after bone marrow transplant (By similarity). Plays a role in hypotensive responses, mediating reduction in intraocular and blood pressure (By similarity). Mediates NAGly-induced process of reorganization of actin filaments and induction of acrosomal exocytosis (PubMed:27572937). {ECO:0000250|UniProtKB:Q8K1Z6, ECO:0000269|PubMed:16844083, ECO:0000269|PubMed:24762058, ECO:0000269|PubMed:27572937}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|7tm 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|alpha-beta intraepithelial T cell differentiation|
|CD8-positive, alpha-beta intraepithelial T cell differentiation|
|CD8-positive, gamma-delta intraepithelial T cell differentiation|
|gamma-delta intraepithelial T cell differentiation|
|gamma-delta T cell differentiation|
|gamma-delta T cell activation|
|CD8-positive, alpha-beta T cell differentiation|
|CD8-positive, alpha-beta T cell activation|
|negative regulation of leukocyte chemotaxis|
|positive regulation of Rho protein signal transduction|
|positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway|
|negative regulation of leukocyte migration|
|alpha-beta T cell differentiation|
|negative regulation of chemotaxis|
|negative regulation of tumor necrosis factor production|
|alpha-beta T cell activation|
|negative regulation of tumor necrosis factor superfamily cytokine production|
|positive regulation of Ras protein signal transduction|
|positive regulation of small GTPase mediated signal transduction|
|phospholipase C-activating G protein-coupled receptor signaling pathway|
|regulation of leukocyte chemotaxis|
|T cell differentiation|
|regulation of Rho protein signal transduction|
|cytoplasmic vesicle membrane|
|regulation of tumor necrosis factor production|
|regulation of tumor necrosis factor superfamily cytokine production|
|regulation of leukocyte migration|
|regulation of chemotaxis|
|T cell activation|
|lymphocyte differentiation|
|regulation of Ras protein signal transduction|
|negative regulation of cell migration|
|negative regulation of cytokine production|
|negative regulation of cell motility|
|positive regulation of cytosolic calcium ion concentration|
|negative regulation of cellular component movement|
|negative regulation of locomotion|
|regulation of cytosolic calcium ion concentration|
|leukocyte differentiation|
|regulation of small GTPase mediated signal transduction|
|negative regulation of response to external stimulus|
|lymphocyte activation|
|cellular calcium ion homeostasis|
|negative regulation of immune system process|
|calcium ion homeostasis|
|cellular divalent inorganic cation homeostasis|
|divalent inorganic cation homeostasis|
|cellular metal ion homeostasis|
|hemopoiesis|
|hematopoietic or lymphoid organ development|
|metal ion homeostasis|
|cellular cation homeostasis|
|cellular ion homeostasis|
|immune system development|
|regulation of cytokine production|
|cation homeostasis|
|inorganic ion homeostasis|
|G protein-coupled receptor activity|
|cellular chemical homeostasis|
|ion homeostasis|
|regulation of cell migration|
|cellular homeostasis|
|regulation of cell motility|
|leukocyte activation|
|regulation of locomotion|
|regulation of cellular component movement|
|positive regulation of intracellular signal transduction|
|cell activation|
|regulation of response to external stimulus|
|chemical homeostasis|
|negative regulation of multicellular organismal process|
|G protein-coupled receptor signaling pathway|
|integral component of plasma membrane|
|negative regulation of response to stimulus|
|homeostatic process|
|positive regulation of signal transduction|
|regulation of immune system process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp314|Dimethyloxaloylglycine 11μM R07 exp314]]|1.75|
|[[:results:exp139|Nicotinamide Riboside 100μM R03 exp139]]|1.86|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13347
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.0 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GPR18 Expression in NALM6 Cells: 4.0'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>